Cellular mechanisms underlying synaptic plasticity in the thalamostriatal inputs

• Project/Area Number: 21500380
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: MIURA Masami 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 専門副部長 (40291091)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 生理学 / 脳・神経 / 大脳基底核 / 姿勢・運動 / 脳神経

Research Abstract

The balance between acetylcholine and dopamine in the striatum conducts the synaptic plasticity in the striatum. Intrinsic striatal cholinergic interneurons receive excitatory thalamostriatal inputs and then change levels of endogenous acetylcholine. In theμ-opioid receptor(MOR)-rich striosomes, activation of PKC via M1 muscarinic receptors attenuated the suppressive effect of MOR on the GABAergic inputs to the projection neurons. These results suggest that reduction of endogenous acetylcholine can increase the excitability of the striatal neural circuits by facilitating the disinhibition of projection neurons.

Research Products

• [Journal Article] Imbalanced suppression of excitatory and inhibitory synaptic transmission onto mouse striatal projection neurons during start of anesthesia induction with sevoflurane in vitro. (2012)
  • Author(s): Ose, Y., Miura, M., Inoue, R., Andou, N., Aosaki, T., Nishimura, K.
  • Journal Title: European Journal of Neuroscience Volume: 35 Issue: 9 Pages: 1396-1405
  • DOI: 10.1111/j.1460-9568.2012.08065.x
  • Peer Reviewed
• [Journal Article] Protein kinase C activity alters the effect ofμ-opioid receptors on inhibitory postsynaptic current in the striosomes (2012)
  • Author(s): Inoue R, Aosaki T and Miura M
  • Journal Title: Neuroreport Volume: 23 Pages: 184-188
  • Peer Reviewed
• [Journal Article] Protein kinase C activity alters the effect of μ-opioid receptors on inhibitory postsynaptic current in the striosomes (2012)
  • Author(s): Inoue R., et al
  • Journal Title: Neuroreport Volume: 23 Pages: 184-188
  • Peer Reviewed
• [Journal Article] Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum (2011)
  • Author(s): Masuda M, Miura M, Inoue R, Imanishi M, Saino-Saito S, Takada M, Kobayashi K, Aosaki T
  • Journal Title: Eur J Neurosci Volume: 34 Pages: 1355-1367
  • Peer Reviewed
• [Journal Article] Postnatal development of tyrosine hydroxylase mRNAexpressing neurons in mouse neostriatum (2011)
  • Author(s): Masuda M, Miura M, Inoue R, Imanishi M, Saino-Saito S, Takada M, Kobayashi K, Aosaki T
  • Journal Title: Eur J Neurosci Volume: 34 Issue: 9 Pages: 1355-1367
  • DOI: 10.1111/j.1460-9568.2011.07873.x
  • Peer Reviewed
• [Journal Article] Activin plays a key role in the maintenance of long-term memory and late-LTP (2010)
  • Author(s): Ageta H, Ikegami S, Miura M, Masuda M, Migishima R, Hino T, Takashima N, Murayama A, Sugino H, Setou M, Kida S, Yokoyama M, Hasegawa Y, Tsuchida K, Aosaki T, Inokuchi K
  • Journal Title: Learn Mem Volume: 17 Pages: 176-185
  • Peer Reviewed
• [Journal Article] Acetylcholine-dopamine balance hypothesis in the striatum : an update (2010)
  • Author(s): Aosaki, T., Miura, M., Suzuki, T., Nishimura, K. and Masuda, M
  • Journal Title: Geriatr Gerontol Int Volume: 10 Pages: 148-157
  • NAID: 10027273560
  • Peer Reviewed
• [Journal Article] Acetylcholine-dopamine balance hypothesis in the striatum : an update. (2010)
  • Author(s): Aosaki T, Miura M , et al.
  • Journal Title: Gerontol Int. Volume: 10(Supp 1)
  • NAID: 10027273560
  • Peer Reviewed
• [Journal Article] Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene underlying "behavioral despair" in mice. (2010)
  • Author(s): Ebihara S, Tomida S, Mamiya T, Sakamaki H, Miura M, et al.
  • Journal Title: Sleep and Biological Rhythms Volume: 8(2) Pages: 114-119
  • Peer Reviewed
• [Journal Article] Activin Bi-directionally Controls the Fate of Fear Memory. (2010)
  • Author(s): Ageta H, Ikegami S, Miura M, et al.
  • Journal Title: Learning and Memory Volume: 17 Pages: 176-185
  • Peer Reviewed
• [Journal Article] マウス線条体チロシンヒドロキシラーゼmRNA陽性細胞の生理学的性質 (2010)
  • Author(s): 青崎敏彦、増田正雄、三浦正巳
  • Journal Title: 基礎老化研究 Volume: 34(2) Pages: 733-738
• [Journal Article] Activin plays a key role in the maintenance of long-term memory and late-LMP (2010)
  • Author(s): Ageta H
  • Journal Title: Learning & Memory Vol.17 Pages: 176-185
  • Peer Reviewed
• [Journal Article] Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests (2009)
  • Author(s): Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T. and Ebihara S
  • Journal Title: Nat Genet Volume: 41 Pages: 688-695
  • Peer Reviewed
• [Journal Article] Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice (2009)
  • Author(s): Sato T, Miura M, Yamada M, Yoshida T, Wood J D, Yazawa I, Masuda M, Suzuki T, Shin R M, Yau H J, Liu F C, Shimohata T, Onodera O, Ross C A, Katsuki M, Takahashi H, Kano M, Aosaki T and Tsuji S
  • Journal Title: Hum Mol Genet Volume: 18 Pages: 723-736
  • Peer Reviewed
• [Journal Article] 中枢神経系におけるドーパミン受容体のはたらき (2009)
  • Author(s): 三浦正巳、増田正雄、青崎敏彦
  • Journal Title: 生体の科学 Volume: 60(5) Pages: 412-413
• [Journal Article] 中枢神経系におけるドーパミン受容体のはたらき (2009)
  • Author(s): 三浦正巳
  • Journal Title: 生体の科学 60巻 Pages: 412-413
• [Journal Article] Physiological interaction between acetylcholine and dopamine in the striatum (2009)
  • Author(s): Aosaki T
  • Journal Title: Brain Nerve Vol.61 Pages: 373-380
  • Peer Reviewed
• [Presentation] ニコチン受容体の脱感作は線条体コリン作動性ニューロンへのGABA入力を調節する (2012)
  • Author(s): 三浦正巳
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本
  • Year and Date: 2012-03-29
• [Presentation] ニコチン受容体の脱感作は線条体コリン作動性ニューコンへのGABA入力を調節する (2012)
  • Author(s): 三浦正巳
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本市
  • Year and Date: 2012-03-29
• [Presentation] Suppressive effect on GABAergic inhibitory postsynaptic current via μ-opioid receptor is modulated by endogenous acetylcholine in the mouse striatum (2011)
  • Author(s): Inoue R., et al
  • Organizer: Society for Neuroscience, Neuroscience 2011
  • Place of Presentation: Washington, DC
  • Year and Date: 2011-11-12
• [Presentation] μオピオイドと内在性アセチルコリンがマウス線条体のGABA作動性抑制電流に与える影響 (2011)
  • Author(s): 井上律子
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] μオピオイド受容体作動薬と内在性アセチルコリンがマウス線条体のGABA作動性抑制電流に与える影響Opposite effects of theμ-opioid receptor agonist DAMGO and endogenous acetylcholine on GABAergic IPSC in mouse striatum (2011)
  • Author(s): 井上律子
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-14
• [Presentation] 線条体のチロシン水酸化酵素mRNA陽性細胞の分類と生後発達 (2011)
  • Author(s): 三浦正巳
  • Organizer: 第26回日本大脳基底核研究会
  • Place of Presentation: 箱根
  • Year and Date: 2011-07-03
• [Presentation] マウス線条体におけるμオピオイド受容体の効果に内在性アセチルコリンが及ぼす影響 (2011)
  • Author(s): 井上律子
  • Organizer: 第34回日本基礎老化学会大会
  • Place of Presentation: 新宿
  • Year and Date: 2011-06-16
• [Presentation] マウス線条体におけるμオピオイド受容体の効果に内在性アセチルコリンが及ぼす影響Endogenous acetylcholine attenuates theμ-opioid receptor-induced suppression of GABAergic IPSC in mouse striatum (2011)
  • Author(s): 井上律子
  • Organizer: 第34回日本基礎老化学会大会
  • Place of Presentation: 東京
• [Presentation] 線条体チロシン水酸化酵素mRNA陽性細胞の分類と生後発達 (2011)
  • Author(s): 三浦正巳
  • Organizer: 第26回日本大脳基底核研究会
  • Place of Presentation: 神奈川県・箱根町・パレスホテル箱根
• [Presentation] Suppressive effect on GABAergic IPSC viaμ-opioid receptor is modulated by endogenous acetylcholine in the mouse striatum (2011)
  • Author(s): Inoue R
  • Organizer: The Society for Neuroscience 41st Annual Meeting
  • Place of Presentation: Washington, D. C., USA
• [Presentation] Modulation of GABAergic inhibitory postsynaptic current viaμ-opioid receptors and muscarinic acetylcholine receptors in striosomes of the mouse striatum (2011)
  • Author(s): Inoue R
  • Organizer: The 2nd Japan-Korea International Joint Meeting
  • Place of Presentation: Seoul Korea
• [Presentation] 線条体局所神経回路におけるニコチンの神経伝達調節機能の研究 (2010)
  • Author(s): 三浦正巳
  • Organizer: 喫煙科学助成財団研究発表会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-28
• [Presentation] Dual modulation of GABAergic inputs to cholinergic interneurons in the striosom (2009)
  • Author(s): 三浦正巳
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-18
• [Remarks]
  • URL: http://www.tmghig.jp/J_TMIG/j_research/DA42.html
• [Remarks]
  • URL: http://www.tmig.or.jp/J_TMIG/j_research/DA42.html