Cellular mechanisms underlying synaptic plasticity in the thalamostriatal inputs
| Project/Area Number |
21500380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
MIURA Masami 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 専門副部長 (40291091)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 生理学 / 脳・神経 / 大脳基底核 / 姿勢・運動 / 脳神経 |
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| Research Abstract |
The balance between acetylcholine and dopamine in the striatum conducts the synaptic plasticity in the striatum. Intrinsic striatal cholinergic interneurons receive excitatory thalamostriatal inputs and then change levels of endogenous acetylcholine. In theμ-opioid receptor(MOR)-rich striosomes, activation of PKC via M1 muscarinic receptors attenuated the suppressive effect of MOR on the GABAergic inputs to the projection neurons. These results suggest that reduction of endogenous acetylcholine can increase the excitability of the striatal neural circuits by facilitating the disinhibition of projection neurons.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Imbalanced suppression of excitatory and inhibitory synaptic transmission onto mouse striatal projection neurons during start of anesthesia induction with sevoflurane in vitro.2012
Author(s)
Ose, Y., Miura, M., Inoue, R., Andou, N., Aosaki, T., Nishimura, K.
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Journal Title
European Journal of Neuroscience
Volume: 35
Issue: 9
Pages: 1396-1405
DOI
Related Report
Peer Reviewed
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[Journal Article] Activin plays a key role in the maintenance of long-term memory and late-LTP2010
Author(s)
Ageta H, Ikegami S, Miura M, Masuda M, Migishima R, Hino T, Takashima N, Murayama A, Sugino H, Setou M, Kida S, Yokoyama M, Hasegawa Y, Tsuchida K, Aosaki T, Inokuchi K
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Journal Title
Learn Mem
Volume: 17
Pages: 176-185
Related Report
Peer Reviewed
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[Journal Article] Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests2009
Author(s)
Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T. and Ebihara S
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Journal Title
Nat Genet
Volume: 41
Pages: 688-695
Related Report
Peer Reviewed
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[Journal Article] Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice2009
Author(s)
Sato T, Miura M, Yamada M, Yoshida T, Wood J D, Yazawa I, Masuda M, Suzuki T, Shin R M, Yau H J, Liu F C, Shimohata T, Onodera O, Ross C A, Katsuki M, Takahashi H, Kano M, Aosaki T and Tsuji S
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Journal Title
Hum Mol Genet
Volume: 18
Pages: 723-736
Related Report
Peer Reviewed
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