Characterization of AEP/Legumain-deficient mice as a new model of lysosome disease
| Project/Area Number |
21500387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ASANO Masahide 金沢大学, 学際科学実験センター, 教授 (50251450)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血球貪食症候群 / リソソーム病 / ゴーシェ細胞 / 遺伝子改変動物 / 病態モデル / マクロファージ / 赤血球 / 血液疾患 |
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| Research Abstract |
Asparagine endopeptidase(AEP) is a lysosomal cysteine protease. We have characterized AEP-deficient mice as a disease model of human hemomphagocytic syndrome, which developed hemophagocytosis especially in bone marrow. A part of hemophagpocytes resembled Gaucher cells in Gaucher disease, one of lysosomal storage disease. We have conducted further examinations so as to characterize AEP-deficient mice as a new model of lysosomal disease.
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Report
(4 results)
Research Products
(6 results)
