Characterization of AEP/Legumain-deficient mice as a new model of lysosome disease

Research Project

Project/Area Number	21500387
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Laboratory animal science
Research Institution	Kanazawa University
Principal Investigator	HASHIMOTO Noriyoshi 金沢大学, 学際科学実験センター, 准教授 (50242524)
Co-Investigator(Kenkyū-buntansha)	ASANO Masahide 金沢大学, 学際科学実験センター, 教授 (50251450)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	血球貪食症候群 / リソソーム病 / ゴーシェ細胞 / 遺伝子改変動物 / 病態モデル / マクロファージ / 赤血球 / 血液疾患
Research Abstract	Asparagine endopeptidase(AEP) is a lysosomal cysteine protease. We have characterized AEP-deficient mice as a disease model of human hemomphagocytic syndrome, which developed hemophagocytosis especially in bone marrow. A part of hemophagpocytes resembled Gaucher cells in Gaucher disease, one of lysosomal storage disease. We have conducted further examinations so as to characterize AEP-deficient mice as a new model of lysosomal disease.

Report

(4 results)