Functional analysis of the male-pattern baldness susceptibility locus by using transposon technology
| Project/Area Number |
21500388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University |
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Principal Investigator |
KOKUBU Chikara 大阪大学, 大学院・医学系研究科, 特任講師 (70379238)
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| Co-Investigator(Kenkyū-buntansha) |
KIRA Masahiro 大阪大学, 大学院・医学系研究科, 講師 (90314335)
UNO Yoshihiro 大阪大学, 大学院・医学系研究科, 助手 (80252683)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 疾患モデル / ゲノムエンジニアリング / トランスポゾン |
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| Research Abstract |
An intergenic non-coding region between human PAX1 and FOXA2 gene loci has been reported as a susceptibility locus for human male-pattern baldness by genome-wide association studies. To elucidate the function of the genomic region, we performed transposon-based functional analysis of the corresponding genomic region in the mouse. This allowed mapping of long-range genomic cis-regulatory regions and identification of a wide-variety of enhancer elements. No conclusive evidence has so far been obtained from the mouse to support an association between the Pax1 gene and the hair loss phenotype.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice2009
Author(s)
*Kokubu C., Horie K., Abe K., Ikeda R., Mizuno S., Uno Y., Ogiwara S., Ohtsuka M., Isotani A., Okabe M., Imai K. and Takeda J.
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Journal Title
Nature Genetics
Volume: 41
Pages: 946-952
Related Report
Peer Reviewed
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