Analysis of p53 function in HTLV-1 Tax transgenic mice
| Project/Area Number |
21500390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kumamoto University |
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Principal Investigator |
OHSUGI Takeo 熊本大学, 生命資源研究・支援センター, 准教授 (00211102)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 疾患モデル / 成人T細胞白血病 / HTLV-1 / p53 / 遺伝子改変マウス / tax遺伝子 / ATL / マウス |
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| Research Abstract |
The status of p53 function before the onset of leukemia in Tax-expressing transgenic(Tg) mice was investigated. The decreased p53 transcriptional activity in Tax-Tg mice was a tissue-specific phenomenon related to Tax expression. The decline in p53 function resulted from decreased p53 accumulation after DNA damage. These results suggest that the functional inactivation of p53 by Tax may be critical for the initial onset of leukemia associated with Tax.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway2009
Author(s)
Takahashi-Makise N., Suzu, S., Hiyoshi, M., Ohsugi, T., Katano, H., Umezawa, K. and Okada, S.
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Journal Title
Int J Cancer
Volume: 125
Pages: 1464-1472
Related Report
Peer Reviewed
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[Journal Article] Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway2009
Author(s)
Takahashi-Makise N., Suzu, S., Hiyoshi, M., Ohsugi, T., Katano, H., Umezawa, K., Okada, S.
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Journal Title
Int J Cancer 125
Pages: 1464-1472
Related Report
Peer Reviewed
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