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The creation and application of lifestyle-related diseases in the hyperlipidemia mouse.

Research Project

Project/Area Number 21500392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionMinami Kyusyu University

Principal Investigator

ITO Kaoru  南九州大学, 健康栄養学部, 教授 (70341633)

Co-Investigator(Renkei-kenkyūsha) KOSHIMOTO Chihiro  宮崎大学, フロンティア科学実験総合センター, 教授 (70295210)
ITO Katsuaki  宮崎大学, 農学部, 名誉教授 (70136795)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords疾患モデル / 高脂血症 / 血管機能 / 動脈硬化 / 循環器・高血圧 / 病患モデル
Research Abstract

We evaluated the effect of high cholesterol diet on endothelial function of artery from European wood mice(Apodemus Sylvaticus), some of which spontaneously exhibit hyperlipidemia on a normal diet. According to the plasma cholesterol level, mice were divided into two groups ; hypercholesterol mice and normocholesterol mice. Both mice were fed with a normal or high-cholesterol diet for 5 weeks. The high-cholesterol diet increased the total plasma cholesterol level in both groups. The endothelium-dependent relaxation of isolated aorta was worsened in both mice after high cholesterol feeding. Thus, the endothelium-dependent relaxation was inhibited depending on the total plasma cholesterol level.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 Other

All Presentation (5 results)

  • [Presentation] 高コレステロール食負荷がマウスの血管内皮機能に及ぼす影響2012

    • Author(s)
      伊藤薫、畑中麻衣子、杉山亜紀、川北久美子
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      仙台
    • Related Report
      2011 Final Research Report
  • [Presentation] 高コレステロール食負荷が自然発症高コレステロール血症マウスの血管機能に及ぼす影響2011

    • Author(s)
      畑中麻衣子、川北久美子、杉山亜紀、伊藤薫
    • Organizer
      第58回日本栄養改善学会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高コレステロール食負荷による自然発症高コレステロール血症マウスにおける内皮依存性弛緩反応への影響2011

    • Author(s)
      伊藤薫、畑中麻衣子、川北久美子、中村真理、河野紗也加、越本知大、篠原明男、伊藤勝昭
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 高コレステロール負荷が自然発症高コレステロール血症マウスの血管機能におよぼす影響2011

    • Author(s)
      畑中麻衣子、川北久美子、杉山亜紀、伊藤薫
    • Organizer
      第58回日本栄養改善学会学術総会
    • Place of Presentation
      広島
    • Related Report
      2011 Final Research Report
  • [Presentation] 高コレステロール食負荷による自然発症高コレステロール血症における内皮依存性弛緩反応への影響

    • Author(s)
      伊藤薫
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(東日本大震災により中止抄録掲載により発表扱い)
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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