| Project/Area Number |
21500392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Minami Kyusyu University |
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Principal Investigator |
ITO Kaoru 南九州大学, 健康栄養学部, 教授 (70341633)
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| Co-Investigator(Renkei-kenkyūsha) |
KOSHIMOTO Chihiro 宮崎大学, フロンティア科学実験総合センター, 教授 (70295210)
ITO Katsuaki 宮崎大学, 農学部, 名誉教授 (70136795)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 疾患モデル / 高脂血症 / 血管機能 / 動脈硬化 / 循環器・高血圧 / 病患モデル |
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| Research Abstract |
We evaluated the effect of high cholesterol diet on endothelial function of artery from European wood mice(Apodemus Sylvaticus), some of which spontaneously exhibit hyperlipidemia on a normal diet. According to the plasma cholesterol level, mice were divided into two groups ; hypercholesterol mice and normocholesterol mice. Both mice were fed with a normal or high-cholesterol diet for 5 weeks. The high-cholesterol diet increased the total plasma cholesterol level in both groups. The endothelium-dependent relaxation of isolated aorta was worsened in both mice after high cholesterol feeding. Thus, the endothelium-dependent relaxation was inhibited depending on the total plasma cholesterol level.
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