Establishment of constitutive-and inducible-basophil depletion mouse models to study critical roles in immunological responses
| Project/Area Number |
21500395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | 財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2009-2010) |
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Principal Investigator |
MATSUOKA Kunie 財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 (40291158)
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| Co-Investigator(Kenkyū-buntansha) |
SHITARA Hiroshi 財団法人東京都医学総合研究所, 基盤技術研究センター, 基盤技術研究職員 (90321885)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 疾患モデル / アレルギー / 好塩基球 / IgE / トランスジェニックマウス / ジフテリア毒素 / TRECK法 / Cre-loxP / Cre-loxp |
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| Research Abstract |
We have newly generated basophil-depletion mouse models to study critical roles in immunological responses by Cre-loxP based system using both FcεRIαpromoter and CD49b promoter. After DT administration to the double transgenic mice expressing DTR on basophils, drastic decrease of basophil population were observed in peripheral blood. The mouse models established in this study should be useful and powerful tools to study in vivo roles of basophils.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury2012
Author(s)
Sekine M, Monkawa T, Morizane R, Matsuoka K, Taya C, Akita Y, Joh K, Itoh H, Hayashi M, Kikkawa Y, Kohno K, Suzuki A, Yonekawa H
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Journal Title
Transgenic Res
Volume: 21
Issue: 1
Pages: 51-62
DOI
Related Report
Peer Reviewed
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