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Local administration of autologous synovium-derived cells improve the structural properties of anterior cruciate ligament autograft reconstruction in sheep

Research Project

Project/Area Number 21500400
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHokkaido University

Principal Investigator

KONDO Eiji  北海道大学, 大学院・医学研究科, 講師 (60374724)

Co-Investigator(Kenkyū-buntansha) YASUDA Kazunori  北海道大学, 大学院・医学研究科, 教授 (20166507)
ONODERA Shin  北海道大学, 大学院・医学研究科, 客員准教授 (00359481)
KITAMURA Nobuto  北海道大学, 大学院・医学研究科, 講師 (80447044)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体制御 / 治療 / 靱帯 / 腱組織 / 液性因子
Research Abstract

Background : It is well known that the structural properties of a tendon autograft deteriorate during the remodeling phase after anterior cruciate ligament (ACL) reconstruction.
Hypothesis : A local application of autologous synovium-derived cells cultured in TGF-betal-supplemented medium may inhibit the deterioration of structural properties of the tendon graft after ACL reconstruction.
Study Design : Controlled laboratory study
Methods : Fifty-two mature sheep were used in this study. In each animal, the right knee underwent ACL reconstruction using the semitendinosus tendon autograft. Then, the animals were divided into 5 groups of 10 sheep each. No additional treatments were applied in Group 1, while fibrin sealant was applied around the graft in Group 2. In Group 3, autologous synovium-derived cells cultured in standard medium were applied around the graft with fibrin sealant, while autologous synovium-derived cells cultured in TGF-betal-supplemented medium were applied with fibrin s … More ealant in Group 4. In Group 5, fibrin sealant containing 20-ng TGF-betal was applied around the graft. Each animal was sacrificed at 12 weeks after the surgery. In each group, 7 and 3 sheep were used for biomechanical and histological evaluations, respectively. The remaining two sheep were used to confirm whether the applied cells infiltrated into the graft at 1 week after surgery.
Results : Confocal microscope observations showed that the applied cells that were labeled before implantation infiltrated into the superficial portion of the graft at 1 week. Biomechanically, the maximum load and the stiffness of Groups 4 and 5 were significantly greater than those of Groups 1, 2, and 3. Histologically, necrotic lesions were observed in the core portion of the midsubstance in Groups 1 and 2. In Groups 3, 4, and 5, we could not find any necrotic lesions in the midsubstance. Conclusions : A local application of autologous synovium-derived cells cultured in TGF-beta1-supplemented medium, or fibrin sealant containing TGF-betal, significantly inhibit the natural deterioration of the structural properties of the tendon graft after ACL reconstruction. Less

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (67 results)

All 2012 2011 2010 2009

All Journal Article (26 results) (of which Peer Reviewed: 24 results) Presentation (41 results)

  • [Journal Article] Biomechanical and histological evaluations of the doubled semitendinosus tendon autograft after anterior cruciate ligament reconstruction in sheep2012

    • Author(s)
      Kondo E, Yasuda K, Katsura T, Hayashi R, Kotani Y, Tohyama H.
    • Journal Title

      Am J Sports Med

      Volume: 40(2) Issue: 2 Pages: 315-24

    • DOI

      10.1177/0363546511426417

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A pilot study of anatomic double-bundle anterior cruciate ligament reconstruction with ligament remnant tissue preservation2012

    • Author(s)
      Yasuda K, Kondo E, Kitamura N, Kawaguchi Y, Kai S, Tanabe Y.
    • Journal Title

      Arthroscopy

      Volume: 28(3) Issue: 3 Pages: 343-53

    • DOI

      10.1016/j.arthro.2011.08.305

    • NAID

      120003918923

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Local administration of autologous synovium-derived cells improve the structural properties of anterior cruciate ligament autograft reconstruction in sheep2011

    • Author(s)
      Kondo E, Yasuda K, Katsura T, Hayashi R, Azuma C, Tohyama H.
    • Journal Title

      Am J Sports Med

      Volume: 39(5) Issue: 5 Pages: 999-1007

    • DOI

      10.1177/0363546510390424

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical comparison of anatomic double-bundle, anatomic single-bundle, and nonanatomic single-bundle anterior cruciate ligament reconstructions2011

    • Author(s)
      Kondo E, Merican AM, Yasuda K, Amis AA
    • Journal Title

      Am J Sports Med

      Volume: 39(2) Issue: 2 Pages: 279-88

    • DOI

      10.1177/0363546510392350

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of macrophage migration inhibitory factor gene delays healing of the medial collateral ligament : a biomechanical and biological study2011

    • Author(s)
      Kitayama S, Onodera S, Kondo E, Kobayashi T, Miyatake S, Kitamura N, Tohyama H, Yasuda K.
    • Journal Title

      J Biomech

      Volume: 44(3) Issue: 3 Pages: 494-500

    • DOI

      10.1016/j.jbiomech.2010.09.018

    • NAID

      120002834758

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparisons of femoral tunnel enlargement in 169 patients between single-bundle and anatomic double-bundle anterior cruciate ligament reconstructions with hamstring tendon grafts2011

    • Author(s)
      Kawaguchi Y, Kondo E, Kitamura N, Kai S, Inoue M, Yasuda K.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: 19(8) Issue: 8 Pages: 1249-57

    • DOI

      10.1007/s00167-011-1455-7

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gender-based differences in outcome after anatomic double-bundle anterior cruciate ligament reconstruction with hamstring tendon autografts2011

    • Author(s)
      Tohyama H, Kondo E, Hayashi R, Kitamura N, Yasuda K.
    • Journal Title

      Am J Sports Med

      Volume: 39(9) Issue: 9 Pages: 1849-57

    • DOI

      10.1177/0363546511408864

    • NAID

      120004608952

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo effects of isolated implantation of salmon-derived crosslinked aelocollagen sponge into an osteochondral defect.2011

    • Author(s)
      Kawaguchi Y.
    • Journal Title

      J Mater Sci Mater Med

      Volume: 22 Pages: 397-404

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical evaluation of a novel application of a fixation device for bone-tendon-bone graft (EndoButton CL BTB) to soft-tissue grafts in anatomic double-bundle anterior cruciate ligament reconstruction2010

    • Author(s)
      Miyatake S, Kondo E, Tohyama H, Kitamura N, Yasuda K.
    • Journal Title

      Arthroscopy

      Volume: 26(9) Issue: 9 Pages: 1226-32

    • DOI

      10.1016/j.arthro.2010.01.007

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anatomic double-bundle anterior cruciate ligament reconstruction2010

    • Author(s)
      Yasuda K, Tanabe Y, Kondo E, Kitamura N, Tohyama H.
    • Journal Title

      Arthroscopy

      Volume: 26(9 Suppl) Issue: 9 Pages: S21-S34

    • DOI

      10.1016/j.arthro.2010.03.014

    • NAID

      120002414873

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical comparisons of knee stability after anterior cruciate ligament reconstruction between 2 clinically available transtibial procedures : anatomic double bundle versus single bundle2010

    • Author(s)
      Kondo E, Merican AM, Yasuda K, Amis AA
    • Journal Title

      Am J Sports Med

      Volume: 38(7) Issue: 7 Pages: 1349-58

    • DOI

      10.1177/0363546510361234

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tunnel location in transparent 3-dimensional CT in anatomic double-bundle anterior cruciate ligament reconstruction with the trans-tibial tunnel technique2010

    • Author(s)
      Inoue M, Tokuyasu S, Kuwahara S, Yasojima N, Kasahara Y, Kondo E, Onodera S, Yasuda K.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: 18(9) Issue: 9 Pages: 1176-83

    • DOI

      10.1007/s00167-009-0989-4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implantation of autogenous meniscal fragments wrapped with a fascia sheath enhances fibrocartilage regeneration in vivo in a large harvest site defect.2010

    • Author(s)
      Kobayashi Y.
    • Journal Title

      Am J Sports Med

      Volume: 38 Pages: 740-748

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical comparisons of knee stability after anterior cruciate ligament reconstruction between 2 clinically available transtibial procedures : anatomic double bundle versus single bundle.2010

    • Author(s)
      Kondo E.
    • Journal Title

      Am J Sports Med

      Volume: 38 Pages: 1349-1358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical evaluation of a novel application of a fixation device for bone-tendon-bone graft (EndoButton CL BTB) to soft-tissue grafts in an atomic double-bundle anterior cruciate ligament reconstruction.2010

    • Author(s)
      Miyatake S.
    • Journal Title

      Arthroscopy

      Volume: 26 Pages: 1226-1232

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomic double-bundle anterior cruciate ligament reconstruction.2010

    • Author(s)
      Yasuda K.
    • Journal Title

      Arthroscopy

      Volume: 26

    • NAID

      120002414873

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical comparison of anatomic double-bundle, anatomic single-bundle and non-anatomic single-bundle anterior cruciate ligament reconst ructions.2010

    • Author(s)
      Kondo E.
    • Journal Title

      Am J Sports Med

      Volume: 39 Pages: 279-288

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-stage anatomic double-bundle anterior and posterior cruciate ligament reconstruction using the autogenous hamstring tendons2009

    • Author(s)
      Yasuda K, Kitamura N, Kondo E, Hayashi R, Inoue M.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: 17(7) Issue: 7 Pages: 800-5

    • DOI

      10.1007/s00167-009-0800-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stress deprivation from the patellar tendon induces apoptosis of fibroblasts in vivo with activation of mitogen-activated protein kinases2009

    • Author(s)
      Kawabata H, Katsura T, Kondo E, Kitamura N, Miyatake S, Tanabe Y, Setoguchi T, Komiya S, Yasuda K.
    • Journal Title

      J Biomech

      Volume: 42(15) Issue: 15 Pages: 2611-5

    • DOI

      10.1016/j.jbiomech.2009.07.027

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Randomized clinical comparisons of diclofenac concentration in the soft tissues and blood plasma between topical and oral applications.2009

    • Author(s)
      Miyatake S.
    • Journal Title

      Br J Clin Pharmacol 67

      Pages: 125-129

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect on patellofemoral joint stability of selective cutting of lateral retinacular and capsular structures.2009

    • Author(s)
      Merican AM.
    • Journal Title

      J Biomech 42

      Pages: 291-296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A soluble factor(EMMPRIN)in exudate influences knee motion after total arthroplasty.2009

    • Author(s)
      Onodera J.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 17

      Pages: 298-304

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-stage anatomic double-bundle anterior and posterior cruciate ligament reconstruction using the autogenous hamstring tendons.2009

    • Author(s)
      Yasuda K.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 17

      Pages: 800-805

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo biological responses and bioresorption of tilapia scale collagen as a potential biomaterial.2009

    • Author(s)
      Sugiura H.
    • Journal Title

      Journal of Biomaterials Science : Polymer Edition 20

      Pages: 1353-1368

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      近藤英司
    • Journal Title

      解剖学的2束前十字靱帯再建術後の各移植腱の関節鏡学的評価とその臨床成績との関連.(雑誌整形外科)

      Pages: 683-688

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      近藤英司
    • Journal Title

      ACL損傷に対する再建術式と治療成績-二重束再建術-(Monthly Book Orthopaedics)

      Pages: 43-48

    • Related Report
      2009 Annual Research Report
  • [Presentation] Biomechanical and histological evaluations of the doubled semitendinosus tendon autograft after ACL reconstruction in Sheep2012

    • Author(s)
      Kondo E.
    • Organizer
      The ACL Study Group Meeting 2012
    • Place of Presentation
      アメリカ
    • Year and Date
      2012-02-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biomechanical comparisons of knee stability after anatomic double-bundle ACL reconstruction between 2 clinically available surgical techniques : trans-tibial versus trans-portal procedures2012

    • Author(s)
      Kondo E.
    • Organizer
      The 58th Annual Meeting of the Orthopaedic
    • Place of Presentation
      アメリカ
    • Year and Date
      2012-02-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biomechanical comparisons of knee stability after anatomic double-bundle ACL reconstruction between 2 clinically available surgical techniques : trans-tibial versus trans-portal procedures2012

    • Author(s)
      Kondo E, Merican AM, Yasuda K, Amis AA
    • Organizer
      The 58th Annual Meeting of the Orthopaedic Research Society (ORS)
    • Place of Presentation
      Moscone West Convention Center, San Francisco, California, USA, February
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomechanical and histological evaluations of the doubled semitendinosus tendon autograft after ACL reconstruction in Sheep2012

    • Author(s)
      Kondo E, Tohyama H, Yasuda K.
    • Organizer
      The ACL Study Group Meeting 2012 Hotel Terra
    • Place of Presentation
      Jackson Hole, Wyoming, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 半腱様筋腱を用いた羊膝前十字靭帯再建モデルの生体力学的および組織学的評価2011

    • Author(s)
      近藤英司
    • Organizer
      第38回日本臨床バイオメカニクス学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遺残組織を温存させた前十字靭帯再建術の生体力学的評価:羊モデルによる検討2011

    • Author(s)
      近藤英司
    • Organizer
      第38回日本臨床バイオメカニクス学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biomechanical analysis of partial tears of anteromedial and posterolateral bundles of the anterior cruciate ligament2011

    • Author(s)
      Kondo E, Merican AM, Yasuda K, Amis AA
    • Organizer
      The 57th Annual Meeting of the Orthopaedic Research Society (ORS)
    • Place of Presentation
      The Long Beach Convention Center, Long Beach, California, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Double-network hydrogel implantation induces spontaneous hyaline cartilage regeneration in vivo in a large osteochondral defect created in the femorotibial joint.2011

    • Author(s)
      Yokota M.
    • Organizer
      The 57th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      The Long Beach Convention Center, Long Beach, California, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biomechanical analysis of partial tears of anteromedial and posterolateral bundles of the anterior cruciate ligament.2011

    • Author(s)
      Kondo E.
    • Organizer
      The 57th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      The Long Beach Convention Center, Long Beach, California, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biomechanical comparison between 4-strand posterolateral corner reconstruction and modified larson's procedures after cyclic loading.2011

    • Author(s)
      Miyatake S.
    • Organizer
      The 57th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      The Long Beach Convention Center, Long Beach, California, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo effects of isolated implantation of salmon-derived crosslinked atelocollagen sponge into an osteochondral defect : comparison with porcine atelocollagen sponges.2011

    • Author(s)
      Kawaguchi Y.
    • Organizer
      The 57th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      The Long Beach Convention Center, Long Beach, California, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Graft preparation for anatomic double-bundle ACL reconstruction2010

    • Author(s)
      Kondo E
    • Organizer
      ACL Double-bundle Reconstruction Course
    • Place of Presentation
      University Malaya Medical Centre, Kuala Lumpur, Malaysia
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomechanics of anatomic double-bundle ACL reconstruction2010

    • Author(s)
      Kondo E
    • Organizer
      ACL Double-bundle Reconstruction Course
    • Place of Presentation
      University Malaya Medical Centre, Kuala Lumpur, Malaysia
    • Related Report
      2011 Final Research Report
  • [Presentation] Evidence-based outcome of anatomic double-bundle ACL reconstruction2010

    • Author(s)
      Kondo E
    • Organizer
      ACL Double-bundle Reconstruction Course
    • Place of Presentation
      University Malaya Medical Centre, Kuala Lumpur, Malaysia
    • Related Report
      2011 Final Research Report
  • [Presentation] Evidence-based outcome of anatomic double-bundle ACL reconstruction. ACL2010

    • Author(s)
      Kondo E
    • Organizer
      The 54^<th> Annual Fall Congress of the Korean Orthopaedic Association
    • Place of Presentation
      Grand Hilton Hotel, Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomechanical evaluation of anatomic double-bundle ACL reconstruction using the Anatomic ACL Guide System : comparisons among 3 different procedures2010

    • Author(s)
      Kondo E, Merican A, Yasuda K, Amis A.
    • Organizer
      The ACL Study Group Meeting 2010
    • Place of Presentation
      The LeMeridien Beach Resort in Phuket, Phuket, Thailand
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomechanical evaluation of anatomic double-bundle anterior cruciate ligament reconstruction using the anatomic ACL guide system : comparisons among 3 different procedures2010

    • Author(s)
      Kondo E, Merican AM, Yasuda K, Amis, AA
    • Organizer
      The 56th Annual Meeting of Orthopaedic Research Society (ORS)
    • Place of Presentation
      New Orlends, Louisiana, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomechanical evaluation of anatomic double-bundle anterior cruciate ligament reconstruction using the anatomic ACL guide system : Comparisons among 3 different procedures2010

    • Author(s)
      Kondo E, Merican AM, Yasuda K, Amis, AA
    • Organizer
      The 14^<th> Eurorean Society of Sports Traumatology
    • Place of Presentation
      Knee Surgery and Arthroscopy (ESSKA) Congress, Oslo Spektrum and Radisson Blue Plaza Hotel, Oslo, Norway
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomechanical evaluation of double-bundle anterior cruciate ligament reconstruction : Comparisons among 3 different procedures2010

    • Author(s)
      Kondo E, Merican AM, Yasuda K, Amis, AA
    • Organizer
      6^<th> World Congress of Biomechanics
    • Place of Presentation
      Singapore, Singapore Suntec Convention Centre
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomechanical evaluation of anatomic double-bundle anterior cruciate ligament reconstruction using the anatomic ACL guide system : Comparisons among 3 different procedures.2010

    • Author(s)
      Kondo E.
    • Organizer
      The 14^<th> Eurorean Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) Congress
    • Place of Presentation
      Oslo Spektrum and Radisson Blue Plaza Hotel, Oslo, Norway
    • Related Report
      2010 Annual Research Report
  • [Presentation] Graft preparation for anatomic double-bundle ACL reconstruction.2010

    • Author(s)
      Kondo E.
    • Organizer
      ACL Double-bundle Reconstruction Course.
    • Place of Presentation
      University Malaya Medical Centre, Kuala Lumpur, Malaysia 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biomechanics of anatomic double-bundle ACL reconstruction.2010

    • Author(s)
      Kondo E.
    • Organizer
      ACL Double-bundle Reconstruction Course.
    • Place of Presentation
      University Malaya Medical Centre, Kuala Lumpur, Malaysia 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evidence-based outcome of anatomic double-bundle ACL reconstruction.2010

    • Author(s)
      Kondo E.
    • Organizer
      ACL Double-bundle Reconstruction Course.
    • Place of Presentation
      University Malaya Medical Centre, Kuala Lumpur, Malaysia 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evidence-based outcome of anatomic double-bundle ACL reconstruction.2010

    • Author(s)
      Kondo E.
    • Organizer
      The 54^<th> Annual Fall Congress of the Korean Orthopaedic Association.
    • Place of Presentation
      Grand Hilton Hotel, Seoul, Korea 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biomechanical comparisons between 4-strand anatomic and modified Larson's procedures for posterolateral corner reconstruction.2010

    • Author(s)
      Miyatake S.
    • Organizer
      The 56th Annual Meeting of Orthopaedic Research Society(ORS)
    • Place of Presentation
      Morial Convention Center, New Orlends, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Biomechanical evaluation of anatomic double-bundle anterior cruciate ligament reconstruction using the anatomic ACL guide system : Comparisons among 3 different procedures.2010

    • Author(s)
      Kondo E.
    • Organizer
      The 56th Annual Meeting of Orthopaedic Research Society(ORS)
    • Place of Presentation
      Morial Convention Center, New Orlends, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Implantation of a PAMPS/PDMAAm double-network gel can induce spontaneous hyaline cartilage regeneration in vivo within a large osteochondral defect in a sheep model.2010

    • Author(s)
      Yokota M.
    • Organizer
      The 56th Annual Meeting of Orthopaedic Research Society(ORS)
    • Place of Presentation
      Morial Convention Center, New Orlends, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] The influence of genetic ablation of macrophage migration inhibitory factor on healing of the Achilles' tendon : a biomechanical study2009

    • Author(s)
      Kondo E, Ishikawa T, Fujiki H, Daimaruya M, Onodera S, Yasuda K.
    • Organizer
      The 9^<th> International symposium on ligaments & tendon
    • Place of Presentation
      Las Vegas, NV, USA
    • Year and Date
      2009-02-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Technical Considerations in Double Bundle ACL Reconstruction : Trans-tibialTechnique2009

    • Author(s)
      Kondo E, Yasuda K.
    • Organizer
      The 7th Biennial International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) Congress
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Technical considerations in double bundle ACL reconstruction : Trans-tibial technique2009

    • Author(s)
      Kondo E
    • Organizer
      The Combined Meeting of 39th Malaysian Orthopaedic Association AGM/Annual Scientific Meeting and WENMISS 2009
    • Place of Presentation
      Kota Kinabalu, Sabah, Malaysia
    • Related Report
      2011 Final Research Report
  • [Presentation] Graft preparation and fixation in anatomic double-bundle ACL reconstruction. The biomechanics and the procedure.2009

    • Author(s)
      Kondo E
    • Organizer
      The Combined Meeting of 39th Malaysian Orthopaedic Association AGM/Annual Scientific Meeting and WENMISS 2009
    • Place of Presentation
      Kota Kinabalu, Sabah, Malaysia
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomechanical comparisons between clinically available anatomic double-bundle and single-bundle procedures for anterior cruciate ligament reconstruction2009

    • Author(s)
      Kondo E, Merican A, Yasuda K, Amis A
    • Organizer
      The 55^<th> Annual Meeting of the Orthopaedic Research Society (ORS)
    • Place of Presentation
      The Venetian Hotel Resort Casino/Sands Expo Convention Center, Las Vegas, Nevada
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of application of synovial fibroblasts on properties of the graft after ACL reconstruction2009

    • Author(s)
      Kondo E, Hayashi R, Katsura T, Kitamura N, Miyatake S, Arakaki K, Onodera S, Tohyama H, Yasuda K.
    • Organizer
      The 76th Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS)
    • Place of Presentation
      The Venetian Hotel Resort Casino/Sands Expo Convention Center, Las Vegas, Nevada
    • Related Report
      2011 Final Research Report
  • [Presentation] Local administration of synovium-derived fibroblasts cultured in TGF-beta1-supplemented medium inhibits natural reduction of the structural properties of the tendon autograft after ACL reconstruction : A sheep model study2009

    • Author(s)
      Kondo E, Hayashi R, Katsura T, Azuma C, Tohyama H, Yasuda K.
    • Organizer
      The 7th Biennial International Society of Arthroscopy
    • Place of Presentation
      Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) Congress, Osaka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Technical Considerations in Double Bundle ACL Reconstruction : Trans-tibial Technique.2009

    • Author(s)
      Kondo E
    • Organizer
      The 7th Biennial International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine(ISAKOS)Congress
    • Place of Presentation
      Osaka International Convention Center, Osaka, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Technical considerations in double bundle ACL reconstruction : Trans-tibial technique.2009

    • Author(s)
      Kondo E
    • Organizer
      The Combined Meeting of 39th Malaysian Orthopaedic Association AGM/Annual Scientific Meeting and WENMISS 2009
    • Place of Presentation
      Sutera Harbour Resort, Kota Kinabalu, Sabah, Malaysia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Graft preparation and fixation in anatomic double-bundle ACL reconstruction. The biomechanics and the procedure.2009

    • Author(s)
      Kondo E
    • Organizer
      The Combined Meeting of 39th Malaysian Orthopaedic Association AGM/Annual Scientific Meeting and WENMISS 2009
    • Place of Presentation
      Sutera Harbour Resort, Kota Kinabalu, Sabah, Malaysia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Implantation of autogenous fragments created from the resected meniscus enhances spontaneous in situ regeneration of fibro-cartilage tissues in a large meniscal defect : An in vivo experimental study.2009

    • Author(s)
      Kobayashi Y.
    • Organizer
      The 7th Biennial International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine(ISAKOS)Congress
    • Place of Presentation
      Osaka International Convention Center, Osaka, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo local administration of oteogenic protein-1 improves the mechanical properties of fascicles in overstretched partial ACL injury. A biomechanical study.2009

    • Author(s)
      Hayashi R.
    • Organizer
      The 7th Biennial International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine(ISAKOS)Congress
    • Place of Presentation
      Osaka International Convention Center, Osaka, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prospective clinical comparisons of anatomic double bundle versus single bundle anterior cruciate ligament reconstruction procedures in 328 consecutive patients.2009

    • Author(s)
      Kondo E
    • Organizer
      The 7th Biennial International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine(ISAKOS)Congress
    • Place of Presentation
      Osaka International Convention Center, Osaka, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Local administration of synovium-derived fibroblasts cultured in TGF-beta1-supplemented medium inhibits natural reduction of the structural properties of the tendon autograft after ACL reconstruction. A sheep model study.2009

    • Author(s)
      Kondo E
    • Organizer
      The 7th Biennial International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine(ISAKOS)Congress
    • Place of Presentation
      Osaka International Convention Center, Osaka, Japan
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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