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In situ component selective determination of elastic modulus of bone tissue without loading.

Research Project

Project/Area Number 21500401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHokkaido University

Principal Investigator

SASAKI Naoki  北海道大学, 大学院・先端生命科学研究院, 教授 (40142202)

Co-Investigator(Kenkyū-buntansha) FURUSAWA Kazuya  北海道大学, 大学院・先端生命科学研究院, 助教 (00510017)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords骨バイオメカニクス / X線回折 / 温度因子 / 弾性率 / 温度因子測定 / コラーゲン / 残留応力 / 赤外分光 / 脱灰骨 / ミネラル分率 / コラーゲン強化機構
Research Abstract

Elastic modulus of collagen in bone was determined without loading to the specimen by measuring temperature dependence of X-ray diffraction intensity from collagen. In general, diffraction from collagen in bone is superimposed by that from mineral. We prepared bone specimens with mineral fraction one third of native bone. For these specimens, modulus values of collagen several times larger than that of tendon collagen were obtained. Then, reinforcement of collagen in bone by mineral was confirmed and much larger apparent modulus values for bone collagen than those of tendon collagen were deduced.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (52 results)

All 2012 2011 2010 2009 Other

All Journal Article (15 results) (of which Peer Reviewed: 13 results) Presentation (36 results) Remarks (1 results)

  • [Journal Article] Slow knot formation by suppressed self-reptation in a collapsed polymer chain2012

    • Author(s)
      M. Nakata, Y. Nakamura, and N. Sasaki
    • Journal Title

      Physical Review

      Volume: 85

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Studies on the formation mechanism and the structure of the anisotropic collagen gelprepared by dialysis-induced anisotropic gelation2012

    • Author(s)
      K. Furusawa, S. Sato, J. Masumoto, Y.Hanazaki, Y. Maki, T. Dobashi, T. Yamamoto, A. Fukui, and N. Sasaki
    • Journal Title

      Biomacromolecules

      Volume: 13 Pages: 29-39

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Change in the viscoelastic properties ofagarose gel by HAp precipitation by osteoblasts cultured in an agarose gel matrix2012

    • Author(s)
      Y. Hanazaki, D. Ito, K. Furusawa, A. Fukui, N. Sasaki
    • Journal Title

      Journal of Biorheology in press

      Volume: (印刷中) Issue: 1-2 Pages: 21-28

    • DOI

      10.1007/s12573-011-0043-2

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Slow Knot formation by suppressed self-reptation in a collapsed polymer chain2012

    • Author(s)
      M.Nakata, Y.Nakamura, N.Sasaki
    • Journal Title

      Physical Review E

      Volume: 85 Pages: 0218021-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wide angle X-ray diffraction and small angle X-ray scattering studies on the effect of demineralization on hierarchical structure of bone2011

    • Author(s)
      K. Furusawa, H. Shirakawa, S. Sato, Y. Tomimori, B. Giri, A. Fukui, N. Sasaki
    • Journal Title

      Transactions of the Materials Research Society of Japan

      Volume: 36(2) Pages: 387-391

    • NAID

      130003398980

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wide angle X-ray diffraction and small angle X-ray scattering studies on the effect of demineralization o hierarchical structure of bone2011

    • Author(s)
      K.Furusawa, H.Shirakawa, S.Sato, Y.Tomimori, B.Giri, A.Fukui, N.Sasaki
    • Journal Title

      Transactions of the Materials Research Society of Japan

      Volume: 36 Pages: 387-391

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies on the Fomation Mechanism and the Structure of the Anisotropic Collagen Gel Prepared by Dialysis-Induced Anisotropic Gelation2011

    • Author(s)
      K.Furusawa, S.Sato, J.Masumoto, Y.Hanazaki, Y.Maki, T.Dobashi, T.Yamamoto, A.Fukui, N.Sasaki
    • Journal Title

      Biomacromolecules

      Volume: 13 Pages: 29-39

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pH on Anisotropic Gelation of DNA Induced by Aluminum Cations2010

    • Author(s)
      K. Furusawa, Y. Narazaki, N. Tomita, T. Dobashi, N. Sasaki, and T. Yamamoto
    • Journal Title

      Journal of Physical. Chemistry

      Volume: 114 Pages: 13923-13932

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体組織力学適応の素過程:力学刺激に対する細胞の応答2010

    • Author(s)
      佐々木直樹、古澤和也、福井彰雅、花崎洋平、伊東大輔
    • Journal Title

      日本生体電気・物理刺激研究会誌

      Volume: 24 Pages: 11-16

    • NAID

      40017446680

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of pH on Anisotropic Gelation of DNA Induced by Aluminum Cations2010

    • Author(s)
      K.Furusawa, Y.Narazaki, N.Tomita, T.Dobashi, N.Sasaki, T.Yamamoto
    • Journal Title

      Journal of Physical Chemistrv B

      Volume: 114 Pages: 13923-13932

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elementary process of mechanical adaptation of tissues : Response of cells to mechanical stimulation2010

    • Author(s)
      N.Sasaki, K.Furusawa, A.Fukui, Y.Hanazaki, D.Ito
    • Journal Title

      Journal of the Japanese Bio-Electrical and Physical Stimulation Research Society

      Volume: 24 Pages: 11-16

    • NAID

      40017446680

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Effect of pericellular matrix formation by chondrocytes cultured in agarose gel on the viscoelastic properties of agarose gel matrix2009

    • Author(s)
      Naoki Sasaki, Takahiro Imai, Akiko Hashimoto, Hiroki Yasuda
    • Journal Title

      Journal of Biorheology

      Volume: 23 Pages: 95-101

    • NAID

      40017044568

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deformation of mineral crystals in cortical bone depending on structural anisotropy2009

    • Author(s)
      Bijay Giri, Shigeru Tadano, Kazuhiro Fujisaki, and Naoki Sasaki
    • Journal Title

      Bone

      Volume: 44 Pages: 1111-1120

    • NAID

      120001361369

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pericellular matrix formation by chondrocytes cultured in agarose gel on the viscoelastic properties of agarose gel matrix2009

    • Author(s)
      N.Sasaki, T.Imai, A.Hashimoto, H.Yasuda
    • Journal Title

      Journal of Biorheology 23

      Pages: 95-101

    • NAID

      40017044568

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deformation of mineral crystals in cortical bone depending on structural anisotropy2009

    • Author(s)
      B.Giri, S.Tadano, K.Fujisaki, N.Sasaki
    • Journal Title

      Bone 44

      Pages: 1111-1120

    • NAID

      120001361369

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨塩密度? コラーゲンの状態? -骨バイオメカニクスの要は?2012

    • Author(s)
      佐々木直樹,白川英輝,古澤和也, 福井彰雅
    • Organizer
      第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学豊中キャンパス(豊中市)
    • Year and Date
      2012-01-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of mechanical stimuli on the function of osteoblasts2011

    • Author(s)
      Y. Hanazaki, D. Ito, K. Furusawa, A. Fukui,N. Sasaki
    • Organizer
      4th International Conference on Mechanics of Biomaterials and Tissues
    • Place of Presentation
      Hawai'i, USA
    • Year and Date
      2011-12-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Selective degradation of bone collagen changes the viscoelastic properties of bone Effect of Collagen Degradation on the Viscoelastic Properties of Cortical Bone2011

    • Author(s)
      N.Sasaki, H.Shirakawa, K.Furusawa, A.Fukui
    • Organizer
      4th International Conference on Mechanics of Biomaterials and Tissues
    • Place of Presentation
      Marriott Waikoloa Beach Resort and Spa, Hawai'I, (USA)
    • Year and Date
      2011-12-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of mechanical stimuli on the function of osteoblasts2011

    • Author(s)
      Y.Hanazaki, D.Ito, K.Furusawa, A.Fukui, N.Sasaki
    • Organizer
      4th International Conference on Mechanics of Biomaterials and Tissues
    • Place of Presentation
      Marriott Waikoloa Beach Resort and Spa, Hawai'I, (USA)
    • Year and Date
      2011-12-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Selective degradation of bone collagen changes the viscoelastic properties of bone2011

    • Author(s)
      N. Sasaki, H. Shirakawa, K. Furusawa, A. Fukui
    • Organizer
      4th International Conference on Mechanics of Biomaterials and Tissues
    • Place of Presentation
      Marriott Waikoloa BeachResort and Spa (Hawai'i, USA)
    • Year and Date
      2011-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] コラーゲン水溶液の相分離過程で観察される輸送現象と構造形成2011

    • Author(s)
      古澤和也,増元淳一,長谷部舞,佐藤翔一,福井彰雅,佐々木直樹
    • Organizer
      第59回レオロジー討論会
    • Place of Presentation
      桐生市市民文化会館(桐生市)
    • Year and Date
      2011-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨芽細胞の分化に与える異方性コラーゲンゲルの階層構造の影響2011

    • Author(s)
      佐藤翔一,増元淳一,長谷部舞,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第59回レオロジー討論会
    • Place of Presentation
      桐生市市民文化会館(桐生市)
    • Year and Date
      2011-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 流動複屈折によるアミロイド線維形成の初期過程2011

    • Author(s)
      佐々木直樹、須磨俊輔、古澤和也、福井彰雅
    • Organizer
      第59回レオロジー討論会
    • Place of Presentation
      桐生市市民文化会館(群馬県)
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨芽細胞の分化に与える異方性コラーゲンゲルの階層構造2011

    • Author(s)
      佐藤翔一、増元淳一、長谷部舞、古澤和也、福井彰雅、佐々木直樹
    • Organizer
      第59回レオロジー討論会
    • Place of Presentation
      桐生市市民文化会館(群馬県)
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] ベータラクトグロブリンアミロイド線維の形成機構と物性2011

    • Author(s)
      須磨俊輔,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第59回レオロジー討論会
    • Place of Presentation
      桐生市市民文化会館(桐生市)
    • Year and Date
      2011-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] コラーゲン水溶液の相分離過程で観察される輸送現象と構造形成2011

    • Author(s)
      古澤和也、増元淳一、長谷部舞、佐藤翔一、福井彰雅、佐々木直樹
    • Organizer
      第59回レオロジー討論会
    • Place of Presentation
      桐生市市民文化会館(群馬県)
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 流動複屈折によるアミロイド線維形成の初期過程2011

    • Author(s)
      佐々木直樹、須磨俊輔、河合優一、斉藤有奈、古澤和也、福井彰雅
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Final Research Report
  • [Presentation] グロビュール状態からキャストした高分子フィルムの構造と物性2011

    • Author(s)
      富森由佳、菊野拓人、古澤和也、福井彰雅、佐々木直樹
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Final Research Report
  • [Presentation] ベータラクトグロブリンアミロイド線維の形成機構と物性2011

    • Author(s)
      佐々木直樹、須磨俊輔、河合優一、斉藤有奈、古澤和也、福井彰雅
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学(岡山市)(招待講演)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] グロビュール状態からキャストした高分子フィルムの構造と物性2011

    • Author(s)
      富森由佳、菊野拓人、古澤和也、福井彰雅、佐々木直樹
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of Collagen Degradation on the Viscoelastic Properties of Cortical Bone2011

    • Author(s)
      N. Sasaki, H. Shirakawa, K. Furusawa, A. Fukui
    • Organizer
      12th IUMRS International Conference in Asia
    • Place of Presentation
      Taipei World Trade Center Nangang Exhibition Hall(Taipei, Taiwan)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of Collagen Degradation on the Viscoelastic Properties of Cortical Bone2011

    • Author(s)
      N.Sasaki, H.Shirakawa, K.Furusawa, A.Fukui
    • Organizer
      12th IUMRS International Conference in Asia
    • Place of Presentation
      Taipei Nangang Exhibition Center, (Taiwan)(招待講演)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] アミロイド線維溶液の流動複屈折と線維の弾性率2011

    • Author(s)
      須磨俊輔、斉藤有奈、古澤和也、福井彰雅、佐々木直樹
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学(吹田市)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨芽細胞の機能に及ぼす力学刺激の影響2011

    • Author(s)
      花崎洋平,伊東大輔,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学100周年記念会館(吹田市)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] DNA異方性ゲルの構造とレオロジーに関する研究2011

    • Author(s)
      古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学100周年記念会館(吹田市)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] イオンの拡散によって形成される異方性コラーゲンゲルの形成過程および構造2011

    • Author(s)
      増元淳一,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学100周年記念会館(吹田市)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] アミロイド線維溶液の流動複屈折と線維の弾性率2011

    • Author(s)
      須磨俊輔,斉藤有奈,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学100周年記念会館(吹田市)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨芽細胞の機能に及ぼす力学刺激の影響2011

    • Author(s)
      花崎洋平、伊東大輔、古澤和也、福井彰雅、佐々木直樹
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学(吹田市)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] イオンの拡散によって形成される異方性コラーゲンゲルの形成過程および構造2011

    • Author(s)
      増元淳一、古澤和也、福井彰雅、佐々木直樹
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学(吹田市)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA異方性ゲルの構造とレオロジーに関する研究2011

    • Author(s)
      古澤和也、福井彰雅、佐々木直樹
    • Organizer
      第34回日本バイオレオロジー学会年会
    • Place of Presentation
      関西大学(吹田市)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] アミロイド小線維形成のダイナミックス2010

    • Author(s)
      河合優一,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第58回レオロジー討論会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2010-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] KOH処理骨の粘弾性2010

    • Author(s)
      白川英輝,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第58回レオロジー討論会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2010-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 多価金属カチオンによるDNAのゲル化とその力学特性の研究2010

    • Author(s)
      古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第58回レオロジー討論会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2010-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体組織力学適応の素過程:力学刺激に対する細胞の応答2010

    • Author(s)
      佐々木直樹
    • Organizer
      第37回日本生体電気・物理刺激研究会
    • Place of Presentation
      東京医科大学(東京都) 招待講演
    • Year and Date
      2010-03-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elastic properties of bone collagen with and without mineral particles2009

    • Author(s)
      N. Sasaki, T. Nozoe, K. Furusawa, and A.Fukui
    • Organizer
      Third International Conference on Mechanics of Biomaterials and Tissues
    • Place of Presentation
      Hilton Clearwater Beach Resort (Clearwater Beach, USA)
    • Year and Date
      2009-12-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Elastic properties of bone collagen with and without mineral particles2009

    • Author(s)
      N.Sasaki, T.Nozoe, A.Fukui
    • Organizer
      3^<rd> International Conference on Mechanics of Biomaterials and Tissues
    • Place of Presentation
      Clearwater, FL, USA
    • Year and Date
      2009-12-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨芽細胞によるマトリックス石灰化に対する力学刺激の影響2009

    • Author(s)
      花崎洋平,伊藤大輔,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第32回日本バイオレオロジー学会年会
    • Place of Presentation
      桐生市市民文化会館(桐生市)
    • Year and Date
      2009-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト大腿骨粘弾性の加齢による変化2009

    • Author(s)
      斉藤徹、佐々木直樹、福井彰雅、古澤和也、Peter Zioupos
    • Organizer
      第32回日本バイオレオロジー学会年会
    • Place of Presentation
      桐生市市民文化会館(桐生市)
    • Year and Date
      2009-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 透析によって調製されるDNA異方性ゲルについての研究2009

    • Author(s)
      古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第32回日本バイオレオロジー学会年会
    • Place of Presentation
      桐生市市民文化会館(桐生市)
    • Year and Date
      2009-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] アミロイド線維形成のインキュベーション時間および温度依存性-伸長流動複屈折の測定2009

    • Author(s)
      須磨俊輔,河合優一,古澤和也,福井彰雅,佐々木直樹
    • Organizer
      第32回日本バイオレオロジー学会年会
    • Place of Presentation
      桐生市市民文化会館(桐生市)
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] β-ラクトグロブリンのアルコール変性によるアミロイド小線維形成について2009

    • Author(s)
      河合優一,須磨俊輔,佐々木直樹,福井彰雅,古澤和也
    • Organizer
      第32回日本バイオレオロジー学会年会
    • Place of Presentation
      桐生市市民文化会館(桐生市)
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://altair.sci.hokudai.ac.jp/g1/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-12-18  

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