Mechanism of the inhibition of cancer cell growth using low voltage electric pulses

• Project/Area Number: 21500402
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Okayama University of Science (2010-2011); Tohoku University (2009)
• Principal Investigator: MATSUKI Noriaki 岡山理科大学, 工学部, 教授 (90284520)
• Co-Investigator(Kenkyū-buntansha): 石川 拓司 東北大学, 大学院・工学研究科, 准教授 (20313728)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: エレクトロポレーション / アポトーシス / 低電圧電気パルス / カスパーゼ / 膜透過性

Research Abstract

We previously reported that cancer cell apoptosis was induced through electroporation(membrane pore formation) with the application of low voltage electric pulses(LVEPs). In this study, we reported about the apoptosis mechanism of cancer cells that LVEPs impose cell stress and induce apoptosis through caspases activation of both cell death receptor and mitochondrial pathways following intrcellular Ca++elevation. A series of our studies suggest that LVEPs which might be mild damage to the patients could take place of high voltage electrochemtherapy which is studied as a new anti-cancer therapy.

Research Products

• [Journal Article] Blood flow and cancer cell adhesion in a microchannel with bifurcation and confluence (2011)
  • Author(s): T. Ishikawa, H. Fujiwara, N. Matsuki, Y. Imai, H. Ueno and T. Yamaguchi
  • Journal Title: Biomedical Microdevices Volume: 13 Pages: 159-167
  • Peer Reviewed
• [Journal Article] Fluid particle diffusion through high-hematocrit blood flow within a capillary tube (2011)
  • Author(s): M. Saadatmand, T. Ishikawa, N. Matsuki, M. J. Abdekhodaie, Y. Imai, H. Ueno, T. Yamaguchi
  • Journal Title: Journal of Biomechanics Volume: 44 Pages: 170-175
  • Peer Reviewed
• [Journal Article] Activation of caspases and apotosis in response to low-voltage electric pulses (2010)
  • Author(s): N. Matsuki, M. Takeda, T. Ishikawa, T. Hayasaka, Y. Imai, and T. Yamaguchi
  • Journal Title: Oncology Reports Volume: 23 Pages: 1425-1433
  • Peer Reviewed
• [Journal Article] Activation of caspases and apoptosis in response to low-voltage electric pulses (2010)
  • Author(s): Matsuki N, Takeda M, Ishikawa T, et al.
  • Journal Title: Oncology Reports Volume: 23 Pages: 1425-1433
  • Peer Reviewed
• [Journal Article] Activation of caspases and apoptosis in response to low-voltage electric pulses (2010)
  • Author(s): N.MATSUKI, et.al.
  • Journal Title: ONCOLOGY REPORTS (In press)
  • Peer Reviewed
• [Journal Article] Red blood cell motions in high-hematocrit blood flowing through a stenosed microchannel (2009)
  • Author(s): H. Fujiwara, T. Ishikawa, R. Lima, N. Matsuki, Y. Imai, H. Kaji, M. Nishizawa and T. Yamaguchi
  • Journal Title: Journal of Biomechanics Volume: 42(7) Pages: 838-843
  • Peer Reviewed
• [Presentation] Apoptosis Induction by Low Voltage Electric Pulses (2011)
  • Author(s): N. MATSUKI, S. ICHIBA, K. MATSUMIYA, Y. UJIKE
  • Organizer: 2011 European Multidisciplinary Cancer Congress
  • Place of Presentation: Stockholm