| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The continuous-flow type apparatus for producing hyperpolarized xenon (HP Xe) which can improve the sensitivity by ca. 20,000 times has been successfully developed in the present study. Adopting HP Xe MRI to the lungimaging, we developed the methodology to simultaneously perform the pulmonary functional imaging and the relaxation rate measurement in the brain of HP Xe and investigated the relationship between the two functions of the mouse models of COPD. As a result, the regional abnormalities of the pulmonary funation could be visualized, and the T1i-1was increased compared to that of the healthy mouse. A negative correlation between the T1i-1and the % gas-exchange in the lung was observed.
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