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Magnetic resonance temperature imaging of fat tissue for high intensity focused ultrasound surgery of breast cancer

Research Project

Project/Area Number 21500414
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokai University

Principal Investigator

KURODA Kagayaki  東海大学, 情報理工学部, 教授 (70205243)

Co-Investigator(Kenkyū-buntansha) IMAI Yutaka  東海大学, 医学部, 教授 (70138113)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMRI / 温度 / 脂肪 / 乳がん / 集束超音波 / 緩和時間 / 非侵襲 / 生体情報・計測 / 磁気共鴨 / 縦緩和時間(T1) / メチレン / メチル / 磁気共鳴
Research Abstract

Based on the temperature dependence of T_1 of methylene(CH_2) or methyl(CH_3) protons, we have proposed a temperature imaging technique using multiple flip angle, multipoint Dixon acquisitions. This technique can be combined with the water temperature imaging technique based on the proton resonance frequency(PRF) shift. Feasibility of this technique was demonstrated with phantom experiments.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 2 results) Presentation (24 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 3 results)

  • [Journal Article] Evaluation of a Vessel-Tracking-based Technique for Dynamic Targeting in Human Liver2012

    • Author(s)
      Kokuryo D, Kumamoto E, Takao Y, S Fuji, Kaihara T, K Kuroda
    • Journal Title

      Magn Reson Med

      Volume: 67(1) Pages: 156-163

    • Related Report
      2011 Final Research Report
  • [Journal Article] Temperature Dependence of Relaxation Times in Fatty Acid Proton Components2011

    • Author(s)
      Kuroda K, Iwabuchi T, Obara M, Honda M, Saito K, Imai Y.
    • Journal Title

      Magn Reson Med Sci

      Volume: 10(3) Pages: 177-183

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 研究紹介:磁気共鳴画像化法による生体情報可視化研究における最近のトピックス2010

    • Author(s)
      黒田輝, 比留川英彦, 岩渕拓, 坂井朋範, 齊藤健介, 松尾俊佑, 細川理志, 増貴之
    • Journal Title

      東海大学情報理工学部紀要

      Volume: 10(2) Pages: 17-22

    • Related Report
      2011 Final Research Report
  • [Journal Article] 研究紹介:磁気共鳴画像化法による生体情報可視化研究における最近のトピックス.2010;10(2):17-222010

    • Author(s)
      黒田輝, 比留川英彦, 岩渕拓, 坂井朋範, 齊藤健介, 他
    • Journal Title

      東海大学情報理工学部紀要

      Volume: 10(2) Pages: 11-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 集束超音波治療とMR温度分布画像化の動向2009

    • Author(s)
      黒田輝
    • Journal Title

      Rad Fan

      Volume: 7(9) Pages: 42-45

    • Related Report
      2011 Final Research Report
  • [Journal Article] 研究紹介:磁気共鳴画像化法による生体情報の可視化2009

    • Author(s)
      黒田輝, 大屋萌, 市原雅博, 及川裕貴, 刀川竜一, 比留川英彦, 相澤慎治, 岩渕拓, 齊藤健介, 坂井朋範
    • Journal Title

      東海大学情報理工学部紀要

      Volume: 9(1) Pages: 21-26

    • Related Report
      2011 Final Research Report
  • [Journal Article] 磁気共鳴画像化法による生体情報の可視化2009

    • Author(s)
      黒田輝, 大屋萌, 市原雅博, 他
    • Journal Title

      東海大学情報理工学部紀要 9(1)

      Pages: 21-26

    • NAID

      40016880998

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 集束超音波治療とMR温度分布画像化の動向2009

    • Author(s)
      黒田輝
    • Journal Title

      Rad Fan 7(9)

      Pages: 42-45

    • Related Report
      2009 Annual Research Report
  • [Presentation] Proton Density Ratio Consideration in Optimizing Image Processing in Fat-Water Thermometry using Methylene T1 and Water Resonance Frequency2012

    • Author(s)
      Kuroda K, Takano Y, Obara M, Baron P, Lam MK, Bartels WL, Masatoshi H, Y Imai
    • Organizer
      Proc 20th Annual Meeting Intl Soc Mag Reson Med
    • Place of Presentation
      Montreal
    • Related Report
      2011 Final Research Report
  • [Presentation] Medical device and technique development performed in international medical device alliance in Kobe. Proc The 1st International Symposium of the Daegu-Gyeongbuk Medical Innovation Foundation2011

    • Author(s)
      Kuroda K.
    • Organizer
      DGMIF2011
    • Place of Presentation
      Sesseion
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 水脂肪混在部位のためのメチレン基T1と水共鳴周波数を用いた温度分布画像化法2011

    • Author(s)
      黒田輝, Lam MK, 高野優太, 本田真俊, 小原真, 堀江朋彦, 今井裕
    • Organizer
      第39回日本磁気共鳴医学会大会抄録,日本磁気共鳴医学会雑誌2011;31(Suppl):p.296
    • Place of Presentation
      リーガロイヤルホテル小倉,小倉,北九州
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 温度の本質と非侵襲温度計測技術の展望, Thermal Medicine2011

    • Author(s)
      黒田輝
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Feasibility of Temperature Imaging of Fat and Water based on Methylene T1 and Water Proton Resonance Frequency2011

    • Author(s)
      Kuroda K, Lam MK, Iwabuchi T, Obara M, Honda M, Saito K, Imai Y
    • Organizer
      Proc 19th Annual Meeting Intl Soc Mag Reson Med, Montreal, 2011 ; 19 : p.528
    • Place of Presentation
      Palais des Congres de Montreal, Montreal, Canada
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Feasibility of Temperature Imaging of Fat and Water based on Methylene T1 and Water Proton Resonance Frequency2011

    • Author(s)
      Kuroda K, Lam MK, Iwabuchi T, Obara M, Honda M, Saito K, Baron P, Bartels WL, Y. Imai
    • Organizer
      Proc 19th Annual Meeting Intl Soc Mag Reson Med
    • Place of Presentation
      Montreal
    • Related Report
      2011 Final Research Report
  • [Presentation] 水脂肪混在部位のためのメチレン基T1と水共鳴周波数を用いた温度分布画像化法2011

    • Author(s)
      黒田輝, Lam MK, 高野優太, 本田真俊, 小原真, 堀江朋彦, 今井裕
    • Organizer
      日本磁気共鳴医学会雑誌
    • Related Report
      2011 Final Research Report
  • [Presentation] 多フリップ角法と多点Dixon法を用いた脂肪酸成分のT1による脂肪温度分布の画像化2010

    • Author(s)
      齊藤健介, 岩渕拓, Lam MK, 小原真, 今井裕, 本田真俊, 黒田輝
    • Organizer
      日本磁気共鳴医学会雑誌2010;30 Suppl:p.200.
    • Place of Presentation
      つくば国際会議場,つくば市
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fat temperature imaging with T1 of fatty acid species obtained by multiple flip angle, multipoint Dixon magnetic resonance acquisition.2010

    • Author(s)
      Iwabuchi T, Lam MK, Saito K, Obara M, Honda M, Imai Y, Kuroda K
    • Organizer
      Proc The 3rd Biomedical Engineering International Conference 2010 : p.34.
    • Place of Presentation
      The Clock Tower, Kyoto University, Kyoto
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fat Temperature Imaging with T1 of Fatty Acid Species Using Multiple Flip Angle Multipoint Dixon Acquisitions.P2010

    • Author(s)
      Kuroda K, Iwabuchi T, Lam MK, Obara M, Honda M, Saito K, van Cauteren M, Imai Y
    • Organizer
      roc Joint Annual Meeting, ISMRM-ESMRMB 2010 : p.1818.
    • Place of Presentation
      Stockholmsmassan, Stockholm, Sweden
    • Year and Date
      2010-05-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of Water Resonance Thermal Shift on Methylene T1 Estimation with Multiple Flip Angle Multipoint Dixon Technique for Fat Temperature Imaging2010

    • Author(s)
      Lam MK, Iwabuchi T, Saito K, Kuroda K
    • Organizer
      Proc Joint Annual Meeting, ISMRM-ESMRMB 2010 : p.4128
    • Place of Presentation
      Stockholmsmassan, Stockholm, Sweden
    • Year and Date
      2010-05-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of Water Resonance Thermal Shift on Methylene T1 Estimation with Multiple Flip Angle Multipoint Dixon Technique for Fat Temperature Imaging2010

    • Author(s)
      Lam MK, Iwabuchi T, Saito K, Kuroda K.
    • Organizer
      Proc Joint Annual Meeting
    • Related Report
      2011 Final Research Report
  • [Presentation] Magnetic Resonance Thermometry : Fat Temperature Imaging with T1 of Fatty Acid Species using Multiple Flip Angle Multipoint Dixon Acquisitions. Therma Medicine2010

    • Author(s)
      Kuroda K, Iwabuchi T, Lam MK, Saito K, Honda M, Imai Y.
    • Organizer
      Proc The 5th Asian Congress of Hyperthermia Oncology(ACHO) and The 27th Japanese Congress of Themal Medicine(JCTM)
    • Place of Presentation
      Supplement
    • Related Report
      2011 Final Research Report
  • [Presentation] Fat Temperature Imaging with T1 of Fatty Acid Species Using Multiple Flip Angle Multipoint Dixon Acquisitions2010

    • Author(s)
      Kuroda K, Iwabuchi T, Lam MK, Obara M, Honda M, Saito K, Imai Y.
    • Organizer
      Proc Joint Annual Meeting
    • Related Report
      2011 Final Research Report
  • [Presentation] Fat temperature imaging with T1 of fatty acid species obtained by multiple flip angle, multipoint Dixon magnetic resonance acquisition2010

    • Author(s)
      Iwabuchi T, Lam MK, Saito K, Obara M, Honda M, Imai Y, Kuroda K.
    • Organizer
      Proc The 3rd Biomedical Engineering International Conference
    • Related Report
      2011 Final Research Report
  • [Presentation] 多フリップ角法と多点Dixon法を用いた脂肪酸成分のT1による脂肪温度分布の画像化2010

    • Author(s)
      齊藤健介, 岩渕拓, Mie Kee Lam, 小原真, 今井裕, 本田真俊, 黒田輝
    • Organizer
      日本磁気共鳴医学会雑誌
    • Related Report
      2011 Final Research Report
  • [Presentation] 体内温度イメージングの現状と未来2009

    • Author(s)
      黒田輝
    • Organizer
      (独)放射線医学総合研究所第4回分子イメージング研究センターシンポジウム:生体イメージングの未来
    • Year and Date
      2009-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 低侵襲治療支援のための新しいMRI技術:温度イメージングの現状と未来2009

    • Author(s)
      黒田輝
    • Organizer
      第4回分子イメージング研究センターシンポジウム-生体イメージングの未来-
    • Place of Presentation
      放射線医学総合研究所推進棟大会議室
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂質成分の緩和時間の温度依存性を用いた脂肪温度分布の画像化.2009

    • Author(s)
      岩渕拓, 小原真, 齊藤健介, ヴァンカウテレンマルク, 今井裕, 本田真俊, 黒田輝
    • Organizer
      日本磁気共鳴医学会雑誌2009;29(Supplement) : p. 223.
    • Place of Presentation
      パンパシフィック横浜ベイホテル東急
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] MRIによる非侵襲温度分布画像計測法の高度化2009

    • Author(s)
      黒田輝, 熊本悦子, 高尾好江, 國領大輔, 岩渕拓, 齊藤健介, 今井裕
    • Organizer
      日本ハイパーサーミア学会第26回大会
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] MRIによる非侵襲温度分布画像計測法の高度化2009

    • Author(s)
      黒田輝, 熊本悦子, 高尾好江, 國領大輔, 岩渕拓, 齊藤健介, 小原真
    • Organizer
      日本ハイパーサーミア学会第26回大会,Thermal Medicine 2009;25(Supplement) : p.43.
    • Place of Presentation
      千葉大学けやき会館
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Temperature dependence of relaxation times in individual fatty acid components and its consideration for MR thermometry of adipose tissues.2009

    • Author(s)
      Kuroda K, Obara M, Van Cauteren M, Honda M, Y Imai
    • Organizer
      Proc 17th Annual Meeting ISMRM, Honolulu : p. 2533.
    • Place of Presentation
      Honolulu Convention Center
    • Year and Date
      2009-04-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Temperature dependence of relaxation times in individual fatty acid components and its consideration for MR thermometry of adipose tissues2009

    • Author(s)
      Kuroda K, Obara M, Van Cauteren M, Honda M, Y Imai
    • Organizer
      Proc 17th Annual Meeting ISMRM
    • Place of Presentation
      Honolulu
    • Related Report
      2011 Final Research Report
  • [Presentation] 脂質成分の緩和時間の温度依存性を用いた脂肪温度分布の画像化2009

    • Author(s)
      岩渕拓, 小原真, 齊藤健介, ヴァンカウテレンマルク, 今井裕, 本田真俊, 今井裕, 黒田輝
    • Organizer
      日本磁気共鳴医学会雑誌
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 組織の温度分布計測方法および温度分布画像化法2012

    • Inventor(s)
      黒田輝
    • Industrial Property Rights Holder
      学校法人東海大学
    • Filing Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 組織の温度分布計測方法および温度分布画像化法2012

    • Inventor(s)
      黒田輝
    • Industrial Property Rights Holder
      学校法人東海大学
    • Filing Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 組織の温度分布計測方法および温度分布画像化法組織の温度分布計測方法および温度分布画像化法2010

    • Inventor(s)
      黒田輝
    • Industrial Property Rights Holder
      東海大学
    • Filing Date
      2010-09-29
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 組織の温度分布計測方法及び温度分布画像化方法2010

    • Inventor(s)
      黒田輝
    • Industrial Property Rights Holder
      学校法人東海大学
    • Filing Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 組織の温度分布計測方法及び温度分布画像化方法2009

    • Inventor(s)
      黒田輝
    • Industrial Property Rights Holder
      学校法人東海大学
    • Industrial Property Number
      2009-224432
    • Filing Date
      2009-09-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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