| Project/Area Number |
21500418
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Okayama University of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAIKI Takeru 岡山理科大学, 工学部, 教授 (40241385)
HATTA Takashi 岡山理科大学, 工学部, 教授 (00218497)
ICHIBA Shingo 岡山理科大学, 工学部, 教授 (30284102)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | リモデリング / 血管 / 腱 / 靱帯 / スティフネスパラメータ / 血管収縮能 / 力学的適応変化 / 靭帯 / 組織培養 / 心臓 |
|---|
| Research Abstract |
To precisely study the phenomena of the response of biological soft tissues to mechanical stress, long-term culture systems were developed for tendons/ligaments and blood vessels. These systems can be used to study mechanisms of the biomechanical remodeling of these tissues. Moreover, we have found that long-term in vivo administration of hesperidin, a kind of polyphenol, affects the contractile response of the femoral artery in rabbits. The mechanisms involved in this phenomenon could also be studied with the vascular culture system.
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