Examination of metal allergy induction ability and biocompatibility assessment of a shape memory alloy based on GATA-3 molecule

• Project/Area Number: 21500431
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kitasato University
• Principal Investigator: TAMAUCHI Hidekazu 北里大学, 医学部, 助教 (60188414)
• Co-Investigator(Kenkyū-buntansha): KOMOTORI Jun 慶応義塾大学, 理工学部, 教授 (30225586)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 金属アレルギー / 生体適合材料GATA-3 / 形状記憶合金 / Th2 / GATA-3 / ニッケル / 接触性皮膚炎 / トランスジェニックマウス / サイトカイン / Th2型免疫反応 / 原子吸光

Research Abstract

The precise roles of T helper(Th) 1-type and Th2-type cytokine responses in nickel(Ni)-induced allergic contact dermatitis have not yet been clearly defined. We investigated the involvement of Th2 cytokines in Ni-induced contact hypersensitivity reaction using GATA-3 transgenic(Tg) mice. We confirmed the participation of Th2-type immune reactions in Ni-induced allergy using GATA-3 Tg mice.

Research Products

• [Journal Article] The monitoring possibility of some mammalian cells for zinc concentrations on metallic materials (2012)
  • Author(s): Ogawa A, Okuda N, Hio K, Kanematsu H, Tamauchi H
  • Journal Title: Cytotechnology Volume: 64 Issue: 3 Pages: 341-347
  • DOI: 10.1007/s10616-012-9433-6
  • Peer Reviewed
• [Journal Article] GATA-3 regulates contact hyperresponsiveness in a murine model of allergic dermatitis (2012)
  • Author(s): Tamauchi H, Amoh Y, Itoh M, Terashima M, Masuzawa M, Habu S, Katsuoka K, Iwabuchi K
  • Journal Title: Immunobiology Volume: 217(4) Pages: 446-54
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22112437
  • Peer Reviewed
• [Journal Article] Influence of the nickel-titanium alloy components on biological functions (2011)
  • Author(s): Ogawa A, Akatsuka R, Tamauchi H, Hio K, Kanematsu H
  • Journal Title: BMC Proc Volume: 8 Pages: 79-79
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22373219
  • Peer Reviewed
• [Journal Article] Fucose-containing sulfated polysaccharides from brown seaweeds inhibit proliferation of melanoma cells and induce apoptosis by activation of caspase-3 in vitro (2011)
  • Author(s): Ale MT, Maruyama H, Tamauchi H, Mikkelsen JD, Meyer AS
  • Journal Title: Mar Drugs Volume: 9(12) Pages: 2605-2621
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22363242
  • Peer Reviewed
• [Journal Article] Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo (2011)
  • Author(s): Ale MT, Maruyama H, Tamauchi H, Mikkelsen JD, Meyer AS
  • Journal Title: Int J Biol Macromol Volume: 49(3) Pages: 331-6
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21624396
• [Journal Article] IL-10 controls Th2-type cytokine production and eosinophil infiltration in a mouse model of allergic airway inflammation (2011)
  • Author(s): Kosaka S, Tamauchi H, Terashima M, Maruyama H, Habu S, Kitasato H
  • Journal Title: Immunobiology Volume: 216(7) Pages: 811-20
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21257225
• [Journal Article] Effects of Thermal Oxidation on Biocompatibility of Ni-Ti Shape Memory Alloy (2011)
  • Author(s): Masayoshi Mizutani, Yukiko Matsumura, Jun Komotori and Hidekazu TAMAUCHI
  • Journal Title: TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A Volume: Vol.77, No.784 Pages: 2144-2152
  • NAID: 130002050217
  • URL: http://www.jstage.jst.go.jp/article/kikaia/77/784/77_2144/_article
• [Journal Article] IL-10 controls Th2-type cytokine production and eosinophil infiltration in a mouse model of allergic airway inflammation (2011)
  • Author(s): Kosaka S, Tamauchi H, et al.
  • Journal Title: Immunobiology Volume: Vol.216 Issue: 7 Pages: 811-820
  • DOI: 10.1016/j.imbio.2010.12.003
  • Peer Reviewed
• [Journal Article] Fucoidan from Sargassum sp.and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo (2011)
  • Author(s): Ale MT, Maruyama H, Tamauchi H, et al
  • Journal Title: Int J Biol Macromol Volume: Vol.49 Issue: 3 Pages: 331-336
  • DOI: 10.1016/j.ijbiomac.2011.05.009
  • Peer Reviewed
• [Journal Article] Effects of Thermal Oxidation on Biocompatibility of Ni-Ti Shape Memory Alloy (2011)
  • Author(s): Masayoshi MIZUTANI, Yukiko MATSUMURA, et al
  • Journal Title: TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A Volume: Vol.77 Pages: 2144-2152
  • Peer Reviewed
• [Journal Article] The immune response plays a critical role in the development of nickel-induced allergic contact dermatitis (2010)
  • Author(s): Niiyama S, Tamauchi H, Amoh Y, Terashima M, Matsumura Y, Kanoh M, Habu S, Komotori J, Katsuoka K
  • Journal Title: Int Arch Allergy Immunol Volume: 153(3) Pages: 303-14
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20484930
• [Journal Article] Th2 Immune Response Plays a Critical Role in the Development of Nickel-induced Allergic Contact Dermatitis (2010)
  • Author(s): 新山史朗、玉内秀一、小茂鳥潤
  • Journal Title: Int.Arch Allergy Immunol. Volume: 153 Pages: 303-314
  • Peer Reviewed
• [Presentation] Influence of the nickel titanium alloy componets on biological functions (2011)
  • Author(s): Akiko Ogawa
  • Organizer: 22nd The European Society for Animal Cell Technology
  • Place of Presentation: Austria
  • Year and Date: 2011-05-15
• [Presentation] ニッケルチタン合金対する生体適合性評価系の樹立 (2011)
  • Author(s): 玉内秀一
  • Organizer: 鉄鋼協会第161回春季大講演会
  • Place of Presentation: 東京首都大学(東京都)
  • Year and Date: 2011-03-27
• [Presentation] ニッケルチタン合金の材料料特性と生体への影響.材料とプロセス (2010)
  • Author(s): 小川亜希子, 玉内秀一, 兼松秀行, 樋尾勝也
  • Organizer: 第160回日本鉄鋼協会・秋季講演大会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-26
• [Presentation] ニッケルチタン合金の材料特性と生体への影響 (2010)
  • Author(s): 小川亜希子、玉内秀一
  • Organizer: 鉄鋼協会第160回秋季大講演会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2010-09-25
• [Presentation] Th2 immune response plays a critical role in the development of nickel-induced allergic contact dermatitis (2010)
  • Author(s): Hidekazu Tamauchi, Shiro Niiyama, Yasuyuki Amoh, Masazumi Terashima, Yukiko Matsumura, Maho Kanoh, Sonoko Habu, Jun Komotorr, Kensei Katsuoka
  • Organizer: 14Th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-26
• [Presentation] Th2 Immune Response Plays a Critical Role in the Development of Nickel-induced Allergic Contact Dermatitis (2010)
  • Author(s): 玉内秀一、小茂鳥潤
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-08-26
• [Presentation] フコイダンのヒト腸内細菌による分解と生理活性について (2010)
  • Author(s): 丸山弘子, 川上文貴, 玉内秀一, 蓮沼良一, 吉永恵子, 仲野隆久, 北里英郎
  • Organizer: 第13回北里微生物アカデミー
  • Place of Presentation: 十和田
  • Year and Date: 2010-08-06
• [Presentation] 金属アレルギーについて (2009)
  • Author(s): 玉内秀一
  • Organizer: 第5回HACCP対応抗菌環境福祉材料開発研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-05
• [Presentation] 金属アレルギーについて (2009)
  • Author(s): 玉内秀一
  • Organizer: 第5回HACCP対応環境福祉材料開発研究会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2009-06-05
• [Presentation] メカブフコイダンの経口投与による紫外線障害に対する抑制効果についての検討 (2009)
  • Author(s): 丸山弘子、玉内秀一、吉永恵子、仲野隆久
  • Organizer: 第63回日本栄養・食糧学会大会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2009-05-22
• [Book] 「死生観からみたいのち」-医学原論演習を振り返って日本医事新報 (2010)
  • Author(s): 玉内秀一
  • Publisher: 日本医事新報社
• [Book] フコイダンと免疫(特集免疫と機能性食品) Functional food (2010)
  • Author(s): 玉内秀一、丸山弘子
  • Publisher: フジメディカル出版
• [Book] 「免疫学の観点からみた浄化槽業務にかかわる感染症」特集浄化槽業務に関わる感染症とその対策 (2010)
  • Author(s): 玉内秀一
  • Publisher: 日本環境整備教育センター
• [Remarks]
  • URL: http://www.komotori.mech.keio.ac.jp/publication.htm