Examination of metal allergy induction ability and biocompatibility assessment of a shape memory alloy based on GATA-3 molecule
| Project/Area Number |
21500431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOMOTORI Jun 慶応義塾大学, 理工学部, 教授 (30225586)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 金属アレルギー / 生体適合材料GATA-3 / 形状記憶合金 / Th2 / GATA-3 / ニッケル / 接触性皮膚炎 / トランスジェニックマウス / サイトカイン / Th2型免疫反応 / 原子吸光 |
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| Research Abstract |
The precise roles of T helper(Th) 1-type and Th2-type cytokine responses in nickel(Ni)-induced allergic contact dermatitis have not yet been clearly defined. We investigated the involvement of Th2 cytokines in Ni-induced contact hypersensitivity reaction using GATA-3 transgenic(Tg) mice. We confirmed the participation of Th2-type immune reactions in Ni-induced allergy using GATA-3 Tg mice.
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Report
(4 results)
Research Products
(26 results)
