Development of artificial blood vessels using type IV collagen aggregates
| Project/Area Number |
21500432
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kogakuin University |
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Principal Investigator |
SHIN Yongchol 工学院大学, 工学部, 准教授 (20291734)
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| Co-Investigator(Kenkyū-buntansha) |
IMAMURA Yasutada 工学院大学, 工学部, 教授 (40201339)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | バイオコンジュゲート材料 / コラーゲン / 細胞外マトリックス / 人工血管 |
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| Research Abstract |
In this study, as the first step of the development of artificial blood vessel that mimics in vivo environment, Endothelial cells(ECs) were cultured in long-term on the aggregates of type IV collagen that is similar to meshwork structure found in the basement membrane, and their morphology and function were evaluated. The ECs in long-term culture on type IV collagen aggregates formed a "paving-stone" sheet more stably than those on reconstituted type I collagen fibrils. In addition, the expression of von Willebrand factor that is involved in blood coagulation and several proteins that are involved in cell-cell adhesion was found in the ECs cultured on type IV collagen aggregates.
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Report
(4 results)
Research Products
(18 results)
