| Project/Area Number |
21500435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUSUNOKI Masanobu 近畿大学, 生物理工学部, 教授 (20282238)
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| Co-Investigator(Renkei-kenkyūsha) |
MASTUMURA Kazuaki 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 准教授 (00432328)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 生体機能材料 / 人工関節軟骨 / 生体材料 / 生物・生体工学 / 超薄膜 / ハイドロキシアパタイト / チタン / セラミックス / バイオメカニクス |
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| Research Abstract |
We studied on a partial repalcementable artificial articular cartilage, composed of polyvinyl alcohol hydrogel(PVM-H), or a composite osteo-chondral device(COD). The COD is able to replace the local lesion of natural articular cartilage. A long-term fixation technique between the COD and osseous tissues was studied. The COD surface must have bio-inert function. On the other hand, in the boundary between the COD and living bone, the osteoconductive adhesion is necessary. That is, the partial selective adhesion function(PSAF) was investigated. We have materialized PSAF in the COD by integration the PVA-H and several kinds of apatite thin film. Biocompatibility, mechanical strength and material property of both PVA-Hs and the thin films were studied.
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