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A new index of" cardiac age" derived from echocardiography : A study for brain-cardio-renal connection and organ damages of hypertension.

Research Project

Project/Area Number 21500447
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKagawa University

Principal Investigator

MASUGATA Hisashi  香川大学, 医学部附属病院, 講師 (70263910)

Co-Investigator(Kenkyū-buntansha) SENDA Shoichi  香川大学, 医学部附属病院, 教授 (30145049)
GODA Fuminori  香川大学, 医学部附属病院, 准教授 (90294769)
奥山 浩之  香川大学, 医学部附属病院, 医員 (50448362)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords心臓年齢 / 高血圧 / 超音波 / 心血管危険因子 / 臓器障害 / 糖尿病 / 脳心腎連関 / 心機能 / 左室肥大 / 脈波速度
Research Abstract

Although pulse wave velocity is the primary indicator of arteriosclerosis and is widely used as an index of vascular age in anti-aging medicine, no index is available to quantify cardiac age. We proposed a" cardiac age" index and sought to clarify its clinical significance. Enrolled in the study were patients with atherosclerosis-related diseases. These patients were divided into normotensive and hypertensive patients. Echocardiography was performed, and brachial-ankle pulse wave velocity(baPWV) was measured using an automatic waveform analyzer. The index of cardiac age was determined as 1000×VSot/ BSA/(VS-AO), where VSot(mm) was the ventricular septal thickness at the left ventricular outflow tract, BSA(m^2) was the body surface area, and VS-AO(degrees) was the angle between the basal ventricular septum and the ascending aorta. The index of cardiac aging correlated significantly with age in both the normotensive and hypertensive patients, and these correlations were closer than those between transmitral E/ A(early to atrial velocity) ratio and age in normotensive and hypertensive patients. The slope between age(x axis) and the index of cardiac age(y axis) was greater in hypertensive(1. 50) than normotensive(1. 32) patients. Stepwise regression analysis showed that age, the presence of hypertension, the left ventricular mass index, the left ventricular end-diastolic dimension, the dimension of left atrium, and the ratio of E to A(E/ A) were independently associated with the index of cardiac age. The index was also significantly correlated with baPWV. The proposed index of cardiac age can quantitatively assess cardiac morphological changes due to aging and/ or hypertension and may be a useful marker of peripheral arterial stiffening.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(30 results)

All 2012 2011 2010 2009

All Journal Article (26 results) (of which Peer Reviewed: 26 results) Presentation (4 results)

  • [Journal Article] Association between Urinary 8-Hydroxydeoxyguanosine, an Indicator of Oxidative Stress, and the Cardio-Ankle Vascular Index in Hypertensive Patients2012

    • Author(s)
      Masugata H, Senda S, Okada H, Himoto T, Goda F, et al
    • Journal Title

      J Atheroscler Thromb

    • NAID

      130004444630

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between Arterial Stiffness and Pulmonary Function in Hypertensive Patients2012

    • Author(s)
      Masugata H, Senda S, Okada H, Himoto T, Goda F, et al
    • Journal Title

      Hypertens Res

      Volume: 35(4) Pages: 388-392

    • NAID

      10030645007

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between Cardiac Function and Pulmonary Function in Hypertensive Patients2012

    • Author(s)
      Masugata H, Senda S, Okada H, Himoto T, Goda F, et al
    • Journal Title

      J Int Med Res

      Volume: 40(1) Pages: 105-114

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of Cardio-Ankle Vascular Index with Brain Natriuretic Peptide Levels in Hypertension2012

    • Author(s)
      Masugata H, Senda S, Himoto T, Okada H, Goda F, et al
    • Journal Title

      J Atheroscler Thromb

      Volume: 19(3) Pages: 255-262

    • NAID

      130004444586

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced Bone Mineral Density in Hypertensive Patients is Associated with Left Ventricular Diastolic Dysfunction, not Left Ventricular Hypertrophy2012

    • Author(s)
      Masugata H, Senda S, et al
    • Journal Title

      Clin Exp Hypertens

      Volume: 34(3) Pages: 176-81

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced Bone Mineral Density in Hypertensive Patients is Associated with Left Ventricular Diastolic Dysfunction, not Left Ventricular Hypertrophy2012

    • Author(s)
      Masugata Hisashi, et al
    • Journal Title

      Clin Exp Hypertens

      Volume: 34(3) Pages: 176-181

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of cardio-ankle vascular index with brain natriuretic Peptide levels in hypertension2012

    • Author(s)
      Masugata Hisashi, et al
    • Journal Title

      J Atheroscler Thromb

      Volume: 19(3) Pages: 255-262

    • NAID

      130004444586

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of Arterial Stiffness to Left Ventricular Function in Patients with Reduced Ejection Fraction2011

    • Author(s)
      Masugata H, Senda S, Himoto T, Okada H, Goda F, et al
    • Journal Title

      Tohoku J Exp Med

      Volume: 225(3) Pages: 141-147

    • NAID

      10030195975

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients2011

    • Author(s)
      Masugata H, Senda S, et al
    • Journal Title

      Hypertens Res

      Volume: 34(7) Pages: 846-850

    • NAID

      10031163268

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia2011

    • Author(s)
      Hosomi N, Masugata H, et al
    • Journal Title

      J Hypertens

      Volume: 29(11) Pages: 2210-2219

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal variation in estimated glomerular filtration rate based on serum creatinine levels in hypertensive patients2011

    • Author(s)
      Masugata H, Senda S, et al
    • Journal Title

      Tohoku J Exp Med

      Volume: 224(2) Pages: 137-142

    • NAID

      10028234190

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between echocardiographic parameters and brain natriuretic peptide levels in treated hypertensive patients2011

    • Author(s)
      Masugata H, Senda S, et al
    • Journal Title

      Clin Exp Hypertens

      Volume: 33(3) Pages: 187-191

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between bone mineral density and arterial stiffness in hypertensive patients2011

    • Author(s)
      Masugata H, Senda S, et al
    • Journal Title

      Tohoku J Exp Med

      Volume: 223(2) Pages: 85-90

    • NAID

      10027806773

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in left ventricular diastolic dysfunction between eccentric and concentric left ventricular hypertrophy in hypertensive patients with preserved systolic function2011

    • Author(s)
      Masugata H, Senda S, et al
    • Journal Title

      J Int Med Res

      Volume: 39(3) Pages: 772-779

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aortic root dilatation as a marker of subclinical left ventricular diastolic dysfunction in patients with cardiovascular risk factors2011

    • Author(s)
      Masugata H, Senda S, et al
    • Journal Title

      J Int Med Res

      Volume: 39(1) Pages: 64-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between echocardiographic parameters and brain natriuretic peptide levels in treated hypertensive patients.2011

    • Author(s)
      Masugata Hisashi
    • Journal Title

      Clin Exp Hypertens

      Volume: 33 Pages: 187-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences between hypertensive and atherosclerotic lesions in retinal arteries assessed by Scheie' s classification in hypertensive patients following stroke2010

    • Author(s)
      Masugata H, Senda S, et al
    • Journal Title

      Clin Exp Hypertens

      Volume: 32(6) Pages: 335-340

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related Decrease in Inferior Vena Cava Diameter Measured with Echocardiography2010

    • Author(s)
      Masugata H, Senda S, Goda F, et al
    • Journal Title

      Tohoku J Exp Med

      Volume: 222(2) Pages: 141-147

    • NAID

      10027085942

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardio-ankle vascular index for evaluating immunosuppressive therapy in a patient with aortitis syndrome2010

    • Author(s)
      Masugata H, Senda S, Goda F, et al
    • Journal Title

      Tohoku J Exp Med

      Volume: 222(1) Pages: 77-81

    • NAID

      10027085724

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aortic annular velocity assessed by tissue Doppler echocardiography as a potential parameter of arterial stiffness2010

    • Author(s)
      Masugata H, Senda S, Goda F, et al
    • Journal Title

      Tohoku J Exp Med

      Volume: 221(2) Pages: 169-174

    • NAID

      10027084910

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Echocardiographic assessment of the cardio-renal connection : is left ventricular hypertrophy or diastolic function more closely correlated with estimated glomerular filtration rate in patients with cardiovascular risk factors?2010

    • Author(s)
      Masugata H, Senda S, Goda F, et al
    • Journal Title

      Clin Exp Hypertens

      Volume: 32(2) Pages: 113-120

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences between hypertensive and atherosclerotic lesions in retinal arteries assessed by Scheie's classification in hypertensive patients following stroke.2010

    • Author(s)
      Masugata Hisashi
    • Journal Title

      Clin Exp Hypertens

      Volume: 32 Pages: 335-340

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aortic annular velocity assessed by tissue Doppler echocardiography as a potential parameter of arterial stiffness.2010

    • Author(s)
      Masugata Hisashi
    • Journal Title

      Tohoku J Exp Med

      Volume: 221 Pages: 169-174

    • NAID

      10027084910

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influences of hypertension and diabetes on normal age-related changes in left ventricular function as assessed by tissue Doppler echocardiography2009

    • Author(s)
      Masugata H, et al.
    • Journal Title

      Clin Exp Hypertens 31(5)

      Pages: 400-414

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients2009

    • Author(s)
      Masugata H, et al.
    • Journal Title

      Hypertens Res. 32(12)

      Pages: 1136-1142

    • NAID

      10026125158

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Independent determinants of the Tei index hi hypertensive patients with preserved left ventricular systolic function2009

    • Author(s)
      Masugata H, et al.
    • Journal Title

      Int Heart J. 50(3)

      Pages: 331-340

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Correlation of Arterial Stiffness to Cardiac Function in Patients with Preserved and Reduced Left Ventricular Ejection Fraction2012

    • Author(s)
      舛形尚, 他
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 大動脈弁輪部速度計測の提唱:僧帽弁輪部速度との比較および大動脈硬度よの関係2010

    • Author(s)
      舛形尚, 他
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 大動脈弁輪部速度計測の提唱:僧帽弁輪部速度との比較および大動脈硬度の関係2010

    • Author(s)
      舛形尚
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Influences of Hypertension and Diabetes on Normal Age-related Changes in Left Ventricular Function as Assessed by Tissue Doppler Echocardiography2010

    • Author(s)
      舛形尚
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都市・国立京都国際会館
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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