Sonodynamic therapy of gastric cancer using novel sonosensitizers

• Project/Area Number: 21500448
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Kyushu University
• Principal Investigator: KONISHI Kouzou 九州大学, 大学病院, 特任助教 (90380641)
• Co-Investigator(Kenkyū-buntansha): MURAGAKI Yoshihiro 東京女子医科大学, 医学部, 教授 (70210028)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 音響化学療法 / 収束超音波 / ナビゲーション医療 / 医療・福祉 / 外科

Research Abstract

Sonodynamic therapy, the ultrasound dependent enhancement of cytotoxic activities of certain compounds(sonosensitizers) in studies with cells in vitro and in tumor bearing animals. In this study, we describes a bifunctional agents that combine two modalities into a single cost容ffective" see and treat" approach, namely, a single agent that can be used for contrast agent-enhanced ultrasonographic imaging followed by targeted sonodynamic therapy.

Research Products

• [Journal Article] Augmented reality navigation system for laparoscopic splenectomy in children based on preoperative CT image using optical tracking device. (2012)
  • Author(s): Ieiri S, Uemura M, Konishi K, Souzaki R, Nagao Y, Tsutsumi N, Akahoshi T, Ohuchida K, Ohdaira T, Tomikawa M, Tanoue K, Hashizume M, Taguchi T
  • Journal Title: Pediatr Surg Int.
  • Peer Reviewed
• [Journal Article] Successful resection of an undifferentiated sarcoma in a child using a real-time surgical navigation system in an open magnetic resonance imaging operation room. AR (2011)
  • Author(s): Souzaki R, Kinoshita Y, Matsuura T, Tajiri T, Taguchi T, Ieiri S, Hong J, Uemura M, Konishi K, Tomikawa M, Tanoue K, Hashizume M, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y.
  • Journal Title: J Pediatr Surg Volume: 46(3) Pages: 608-11
  • Peer Reviewed
• [Journal Article] Augmented reality navigation system for laparoscopic splenectomy in children based on preoperative CT image using optical tracking device (2011)
  • Author(s): Ieiri S, Uemura M, Konishi K, et al
  • Journal Title: Pediatr Surg Int Volume: (Epub)
  • Peer Reviewed
• [Journal Article] Successful resection of an undifferentiated sarcoma in a child using a real-time surgical navigation system in an open magnetic resonance imaging operation room (2011)
  • Author(s): Souzaki R, Kinoshita Y, Matsuura T, Tajiri T, Taguchi T, Ieiri S, Hong J, Uemura M, Konishi K, et al
  • Journal Title: J Pediatr Surg Volume: 46 Pages: 608-611
  • Peer Reviewed
• [Journal Article] Value of laparoscopic splenectomy as salvage treatment for relapsed thrombocytopenia after partial splenic arterial embolization (2010)
  • Author(s): Hashimoto N, Akahoshi T, Tomikawa M, Kawanaka H, Konishi K, et al
  • Journal Title: Dig Surg Volume: 27 Pages: 515-520
  • Peer Reviewed
• [Journal Article] Real-Time 3-Dimensional Virtual Reality Navigation System with Open MRI for Breast-Conserving Surgery. (2010)
  • Author(s): Tomikawa M, Hong J, Shiotani S, Tokunaga E, Konishi K, et al
  • Journal Title: J Am Coll Surg Volume: 210(6) Pages: 927-933
  • Peer Reviewed
• [Journal Article] Effectiveness of basic endoscopic surgical skill training for pediatric surgeons. (2010)
  • Author(s): Ieiri S, Nakatsuji T, Higashi M, Akiyoshi J, Uemura M, Konishi K, et al
  • Journal Title: Pediatr Surg Int Volume: 26(10) Pages: 947-954
  • Peer Reviewed
• [Journal Article] Objective assessment of laparoscopic suturing skills using a motion-tracking system. (2010)
  • Author(s): Yamaguchi S, Yoshida D, Kenmotsu H, Yasunaga T, Konishi K, et al
  • Journal Title: Surgical Endoscopy Volume: (in press)
  • Peer Reviewed
• [Journal Article] 治療器具としての未来型内視鏡 Endoscopy in the Future. (2010)
  • Author(s): 小西晃造、橋爪誠
  • Journal Title: 医薬の門 Volume: 49(6) Pages: 54-59
• [Journal Article] 内視鏡・内視鏡外科治療最前線 インテリジェント消化器内視鏡 (2010)
  • Author(s): 小西晃造、橋爪誠
  • Journal Title: 日本臨床 Volume: 68(7) Pages: 1279-1284
• [Journal Article] 早期大腸癌の精密画像診断 共焦点レーザー内視鏡 (2010)
  • Author(s): 掛地吉弘、佐伯浩司、小西晃造, et al
  • Journal Title: 胃と腸 Volume: 45(5) Pages: 868-871
• [Journal Article] 最新のナビゲーション技術によるロボット手術 Image-guided robotic surgery. (2010)
  • Author(s): 家入里志, 小西晃造, et al
  • Journal Title: Surgery Frontier Volume: 17(3) Pages: 17-24
• [Journal Article] A real-time three-dimensional virtual reality navigation system with open magnetic resonance imaging for breast-conserving surgery (2010)
  • Author(s): Tomikawa M, Hong J, Shiotani S, Tokunaga E, Konishi K, Ieiri S, Tanoue K, Akahoshi T, Maehara Y, Hashizume M
  • Journal Title: Journal of the American College of Surgeons(IF3.692) (in print)
  • Peer Reviewed
• [Journal Article] Tumor ablation therapy of liver cancers with an open magnetic resonance imaging-based navigation system (2009)
  • Author(s): Maeda T, Hong J, Konishi K, Nakatsuji T, Yasunakga T, Yamashita Y, Taketomi A, Kotoh K, Enjoji M, Nakashima H, Tanoue K, Maehara Y, Hashizume M
  • Journal Title: Surgical Endoscopy 23 Pages: 1048-1053
  • Peer Reviewed
• [Journal Article] Open MRI Guided Surgical Navigation for Liver Tumor Ablation Therapy (2009)
  • Author(s): Hong J, Tomikawa M, Konishi K, Hashizume M
  • Journal Title: Proc.of 6th URAI Pages: 69-70
  • Peer Reviewed
• [Presentation] 内視鏡下外科手術を安全に行うために～画像重畳を用いた画像誘導下手術ナビゲーションシステムの開発 (2011)
  • Author(s): 植村宗則,長尾占泰,家入里志,小西晃造,大平猛,橋爪誠
  • Organizer: 第24回日本内視鏡外科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-12-09
• [Presentation] Open MRIを応用した3次元バーチャル画像によるリアルタイムナビゲーション下乳腺部分切除術 (2011)
  • Author(s): 富川盛雅,洪在成,植村宗則,小西晃造,家入里志,塩谷聡子,徳永えり子,前原喜彦,橋爪誠
  • Organizer: 第50回目本生体医工学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-01
• [Presentation] CFD(数値流体力学)を用いた血管血流シュミレーションにおけるfeasibilityの検討 (2011)
  • Author(s): 植村宗則,小西晃造,赤星朋比古,富川盛雅,橋爪誠
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-29
• [Presentation] Open MRIを応用した3次元バーチャル画像によるリアルタイムナビゲーション下乳腺部分切除術 (2011)
  • Author(s): 富川盛雅, 洪在成, 植村宗則, 小西晃造, 他
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京
• [Presentation] Development of Sheath Manipulator with Spring Backbone for Single Port Endoscopic Surgery. (2010)
  • Author(s): Tomono Y, Kobayashi Y, Sekiguchi Y, Watanabe H, Toyoda K, Konishi K, et al
  • Organizer: The 6th Asian Conference on Computer Aided Surgery2010
  • Place of Presentation: Busan, Korea
  • Year and Date: 2010-11-26
• [Presentation] 腎尿路先天奇形をもつ大腸癌症例に対し、術中ナビゲーションが有用であった一例 (2010)
  • Author(s): 神代竜一, 小西晃造, et al
  • Organizer: 第23回日本内視鏡外科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-20
• [Presentation] ハイパースペクトル内視鏡を用いたin vivo大腸病変解析システムの臨床検討 (2010)
  • Author(s): 小西晃造, 掛地吉弘, 橋爪誠
  • Organizer: 第8回日本消化器外科学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-16
• [Presentation] Development of an integrated information display system and training system for endoscopic surgical robot system for abdominal surgery. (2010)
  • Author(s): Hattori A, Suzuki N, Tanoue K, Ieiri S, Konishi K, et al
  • Organizer: Computer Assisted Radiology and Surgery 24th International Congress and Exhibition
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2010-06-25
• [Presentation] Development of a colon endoscope robot that adjusts its locomotion through the use of reinforcement learning. (2010)
  • Author(s): Trovato G, Shikanai M, Ukawa G, Kinoshita J, Murai N, J.W.Lee, Ishii H, Takanishi A, Tanoue K, Ieiri S, Konishi K, et al
  • Organizer: Computer Assisted Radiology and Surgery 24th International Congress and Exhibition
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2010-06-25
• [Presentation] Quality assessment of codec-based endoscopic surgical imaging transfer system in remote medecine. (2010)
  • Author(s): Ieiri S, Tanoue K, Yoshida D, Nakatsuji T, Konishi K, et al
  • Organizer: Computer Assisted Radiology and Surgery 24th International Congress and Exhibition
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2010-06-25
• [Presentation] ハイパースペクトル内視鏡を用いた大腸病変解析システムの臨床検討 (2010)
  • Author(s): 小西晃造, 神代竜一, et al
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-13
• [Presentation] Open MRI治療室で行う画像誘導による低侵襲手術とその環境整備 (2010)
  • Author(s): 小西晃造, 富川盛雅, et al
  • Organizer: 第4回Open MRI研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-20
• [Presentation] ドーム型立体内視鏡映像提示システム(3DD)の有用性の検討 (2010)
  • Author(s): 鬼丸学, 大内田研宙, 家入里志, 小西晃造, et al
  • Organizer: 平成21年度日本生体医工学会九州支部学術講演会
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-06
• [Presentation] Open MRI治療室で行う画像誘導による内視鏡外科手術とその環境整備 (2010)
  • Author(s): 富川盛雅, 小西晃造, et al
  • Organizer: 平成21年度日本生体医工学会九州支部学術講演会
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-06
• [Presentation] 腎尿路先天奇形をもつ大腸癌症例に対し、術中ナビゲーションが有用であった一例 (2010)
  • Author(s): 神代竜一, 小西晃造, et al
  • Organizer: 平成21年度日本生体医工学会九州支部学術講演会
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-06
• [Presentation] Feasibility and effectiveness of laparoscopic surgery with the real-time augmented reality navigation system in the open MRI therapeutic room. (2010)
  • Author(s): Tomikawa M, Konishi K, et al
  • Organizer: Computer Assisted Radiology and Surgery 24th International Congress and Exhibition
  • Place of Presentation: Geneva, Switzerland
• [Presentation] The real-time MR image-guided surgical robotic system for minimally invasive precision surgery -Evaluation of navigation function for tumor puncture procedures-. (2010)
  • Author(s): Konishi K, Tomikawa M, et al
  • Organizer: Computer Assisted Radiology and Surgery 24th International Congress and Exhibition
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Open MRIシステムを応用したリアルタイム3次元ナビゲーションによる肝癌の局所治療 (2009)
  • Author(s): 富川盛雅, 洪在成, 小西晃造, 東真弓, 前田貴司, 杉町圭史, 祇園智信, 武冨紹信, 古藤和浩, 家入里志, 田上和夫, 前原喜彦, 橋爪誠
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] Open MRIを応用したリアルタイム3次元ナビゲーションシステムによる肝癌の局所治療 (2009)
  • Author(s): 富川盛雅, 洪在成, 小西晃造, 杉町圭史, 祇園智信, 武冨紹信, 家入里志, 田上和夫, 前原喜彦, 橋爪誠
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪