| Project/Area Number |
21500465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
NAGATA Taiji 国際医療福祉大学, 臨床医学研究センター, 教授 (20272552)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Toshiaki 東京大学, 医学部附属病院, 特任准教授 (50227790)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 呼吸リハビリテーション / 慢性閉塞性肺疾患(COPD) / 加圧筋力トレーニング / COPD / サルコペニア / 高齢者 / 酸化ストレス / 加齢 / 炎症 / C反応性タンパク / 筋萎縮 / 静脈コンプライアンス |
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| Research Abstract |
First, we investigated acute effects of KAATSU training on blood coagulation systems in healthy subjects, and found that it did not enhance coagulation systems, proposing that it is a safe method for training. In addition, the significant enhancement of muscle activity on EMG using elastic band or free weight under the restriction of muscle blood flow was observed in both healthy subjects and patients with COPD, compared with control condition(without KAATSU). The level of serum lactic acid and Borg scale under the training with the restricted muscle blood flow were also higher than that under the control condition. Thus, it is very likely that KAATSU training effectively activates muscle activity in both healthy subjects and COPD patients. We also investigated chronic effects of KAATSU training on elderly subjects and patients with COPD. In elderly subjects, KAATSU walking increased muscle mass, and improved QOL and timed up & go or chair stand time. Similarly, KAATSU training improved QOL score, muscle strength and muscle mass in COPD patients, even though a small number of patients were examined. The PImax and PEmax tended to be increased during KAATSU training. Thus, it is suggested that KAATSU training is a useful method for respiratory rehabilitation in patients with COPD. However, further studies using a large number of patients should be required to improve it.
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