Pulmonary rehabilitation in chronic obstructive pulmonary disease with hyperinflation of the lungs

• Project/Area Number: 21500491
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Showa University
• Principal Investigator: IZUMIZAKI Masahiko 昭和大学, 医学部, 講師 (20398697)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 理学療法学 / 呼吸リハビリテーション / リハビリテーション / 慢性閉塞性肺疾患 / シクソトロピー / 肺過膨張 / 呼吸困難 / 呼吸困難感

Research Abstract

We found in healthy human subjects that the thresholds for dyspnea and respiratory frequency were similar during hypercapnia. A positive correlation was found between the thresholds. Dyspnea is a very important symptom of chronic obstructive pulmonary disease(COPD). Lung hyperinflation is a physiologic abnormality in patients with COPD. It progresses dynamically during exercise, contributing to the occurrence of dyspnea and thereby limiting the capacity of exercise. Based on our findings, the resultant dyspnea potentially worsens hyperinflation in COPD because tachypneic breathing patterns likely decrease the duration of expiration and lead to worsening of air trapping. We then found that thixotropy conditioning of chest wall muscles by means of a new device increased the chest wall mobility in the xiphisternal region in COPD patients particularly with lung hyperinflation. In contrast, this conditioning decreased the intensity of dyspnea during a 6-min walk test in COPD patients without lung hyperinflation.

Research Products

• [Journal Article] Coupling of dyspnea perception and tachypneic breathing during hypercapnia (2011)
  • Author(s): Izumizaki M, Masaoka Y, Homma I.
  • Journal Title: Respir Physiol Neurobiol Volume: 179 Pages: 276-286
• [Journal Article] Coupling of dyspnea perception and tachypneic breathing during hypercapnia (2011)
  • Author(s): Izumizaki M, Masaoka Y, Homma I
  • Journal Title: Respiratory Physiology & Neurobiology Volume: 179 Issue: 2-3 Pages: 276-286
  • DOI: 10.1016/j.resp.2011.09.007
  • Peer Reviewed
• [Journal Article] Dopaminergic modulation of exercise hyperpnoea via D(2) receptors in mice (2011)
  • Author(s): Tsuchiya N, Iwase M, Izumizaki M, Homma I
  • Journal Title: Experimental Physiology Volume: 97 Issue: 2 Pages: 228-238
  • DOI: 10.1113/expphysiol.2011.062703
  • Peer Reviewed
• [Journal Article] 呼吸運動のしくみ正常な呼吸状態を知る (2011)
  • Author(s): 泉崎雅彦
  • Journal Title: 呼吸器ケア Volume: 9 Pages: 1242-1247
• [Journal Article] Effects of fasting on hypoxic ventilatory responses and the contribution of histamine H1 receptors in mice. (2011)
  • Author(s): Ohshima Y, Iwase M, Izumizaki M, Nakayama H, Narita H, Homma I
  • Journal Title: Journal of Physiological Sciences Volume: 61 Pages: 73-82
  • NAID: 10029049524
  • Peer Reviewed
• [Journal Article] Two arms as one : position and movement sense in an elbow-matching task. (2011)
  • Author(s): Izumizaki M, Proske U
  • Journal Title: Physiology News Volume: 82 Pages: 26-29
• [Journal Article] The illusion of changed position and movement from vibrating one arm is altered by vision or movement of the other arm. (2010)
  • Author(s): Izumizaki M, Tsuge M, Akai L, Proske U, Homma I
  • Journal Title: Journal of Physiology Volume: 588 Pages: 2789-2800
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 泉崎雅彦(分担著者)
  • Journal Title: 現場の疑問に答える呼吸リハビリ徹底攻Q&A(中外医学社) Pages: 13-17
• [Presentation] 呼吸困難感による呼吸リズムの促進 (2012)
  • Author(s): 泉崎雅彦、政岡ゆり、本間生夫
  • Organizer: 第89回日本生理学大会
  • Place of Presentation: 松本市
  • Year and Date: 2012-03-31
• [Presentation] 呼吸困難感による呼吸リズムの促進 (2012)
  • Author(s): 泉崎雅彦、政岡ゆり、本間生夫
  • Organizer: 第89回日本生理学大会
  • Place of Presentation: 松本
• [Presentation] 安静時のCO2ホメオスターシスは、呼吸のリズム変化では維持できない (2011)
  • Author(s): 大橋傑、泉崎雅彦、本間生夫
  • Organizer: 第88回日本生理学大会
  • Place of Presentation: (震災のため、誌上開催)
  • Year and Date: 2011-03-29
• [Presentation] 呼吸困難感のメカニズム (2009)
  • Author(s): 泉崎雅彦
  • Organizer: 第4回秋田呼吸リハビリテーション懇話会
  • Place of Presentation: 秋田大学(秋田市)
  • Year and Date: 2009-10-24
• [Presentation] Higher state anxiety is associated with lower thresholds for respiratory frequency and air hunger in response to hypercapnia in humans (2009)
  • Author(s): 泉崎雅彦
  • Organizer: XXXVIth International Union of Physiological Sciences Kyoto
  • Place of Presentation: 京都国際会館(京都市)
  • Year and Date: 2009-07-29
• [Presentation] Higher state anxiety is associated with lower thresholds for respiratory frequency and air hunger in response to hypercapnia in humans (2009)
  • Author(s): Izumizaki M, Homma I
  • Organizer: XXXVIth International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] 呼吸困難感のメカニズム (2009)
  • Author(s): 泉崎雅彦
  • Organizer: 4回秋田呼吸リハビリテーション懇話会
  • Place of Presentation: 秋田
• [Book] 身体運動と呼吸・循環機能 (2012)
  • Author(s): 政岡ゆり、泉崎雅彦(分担著者)
  • Publisher: 真興交易(印刷中)
• [Book] 第3版リハ実践テクニック呼吸ケア、呼吸困難感のメカニズム (2011)
  • Author(s): 泉崎雅彦
  • Publisher: メジカルビュー
• [Book] 第3版リハ実践テクニック呼吸ケア (2011)
  • Author(s): 泉崎雅彦(分担著者)
  • Publisher: メジカルビュー
• [Book] 呼吸ケア・リハビリテーションMini(分担著者)、患者教育の実践 (2010)
  • Author(s): 泉崎雅彦
  • Publisher: 中外医学社
• [Book] 理学療法士のためのコンディショニング入門、呼吸困難とコンディショニング (2010)
  • Author(s): 泉崎雅彦
  • Publisher: 中山書店
• [Book] 呼吸ケア・リハビリテーションMini (2010)
  • Author(s): 泉崎雅彦(分担著者)
  • Publisher: 中外医学社
• [Book] 理学療法士のためのコンディショニング入門 (2010)
  • Author(s): 泉崎雅彦(分担著者)
  • Publisher: 中山書店
• [Book] ベッドサイドで役立つ呼吸アセスメントQ&A101 (2010)
  • Author(s): 泉崎雅彦(分担著者)
  • Publisher: メディカ出版
• [Book] 身体運動と呼吸・循環機能、情動と換気応答
  • Author(s): 政岡ゆり、泉崎雅彦
  • Publisher: 真興交易(印刷中)