| Project/Area Number |
21500493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KAKUDA Wataru 東京慈恵会医科大学, 医学部, 講師 (00453788)
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| Co-Investigator(Kenkyū-buntansha) |
ABO Masahiro 東京慈恵会医科大学, 医学部, 教授 (00266587)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 経頭蓋磁気刺激 / 経頭蓋直流電気刺激 / 脳卒中 / 機能回復 / 上肢麻痺 / 作業療法 / 痙縮 / TMS / tDCS |
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| Research Abstract |
The main purpose of this study was to clarify the most beneficial therapeutic approach for upper limb hemiparesis after stroke among some modalities of repetitive transcranial magnetic stimulation(RTMS) and transcranial direct current stimulation(TDCS), and to investigate the clinical effect of combined application of RTMS/TDCS and intensive rehabilitative training. As a result, consecutive application of low-frequency RTMS over the non-lesional hemisphere with intensive occupational therapy was safe and seemed to have a potential to improve motor function of the affected upper limb in post-stroke patients. In addition, this combination significantly reduced abnormally increased muscle tonus of the affected upper limb, indicating the anti-spastic effect of the intervention. Unfortunately, the effect of TDCS on upper limb motor function after stroke has not been elucidated sufficiently so far, because of unexpected mechanical trouble with the device.
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