Establishment of therapies for pharyngeal dysphagia-Botulinum toxin injection therapy and functional electrical stimulation-
Project/Area Number |
21500500
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Rehabilitation science/Welfare engineering
|
Research Institution | Fujita Health University (2011) Kawasaki Medical School (2009-2010) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Toshiyasu 岡山理科大学, 工学部, 教授 (20412158)
METANI Hiromichi 川崎医科大学, 医学部, 講師 (30330583)
椿原 彰夫 川崎医科大学, 医学部, 教授 (10138117)
|
Co-Investigator(Renkei-kenkyūsha) |
TSUBAHARA Akio 川崎医科大学, 医学部, 教授 (10138117)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 嚥下障害 / 電気刺激 / リハビリテーション医学 / 摂食・嚥下障害 / A型ボツリヌス毒素 / 治療的電気刺激 / 輪状咽頭筋 |
Research Abstract |
We evaluated the effectiveness of a cricopharyngeal block using a local anesthetic agent in advance and administered BTX-A injections in various patients with dysphagia. The criteria for this study were : (1) patients with a history of dysphagia who did not improve with conventional swallowing therapy after more than 3 months, (2) oropharyngeal dysphagia in which UES dysfunction appeared to be the primary cause based on videofluorography. A percutaneous lidocaine injection into the cricopharyngeal muscle was first administered in patients who met the above criteria in order to determine the application of BTX-A injections. In cases where the lidocaine injection was judged to improve the passage of bolus in the area of UES using videofluorography, the patients then received a BTX-A injection. Thirty-nine patients met the criteria for the lidocaine injection. The BTX-A injection was done for 28 patients(72%). In 26 patients out of this group(93%), the passage of bolus improved in the area of UES at 1 month after the BTX-A injection. BTX-A is a very effective treatment in selected patients. A local anesthetic agent trial may predict the effectiveness of BTX-A injection. From the viewpoint of functional electric stimulation(FES), we investigated a surface electrode stimulation method to support laryngeal elevation in helthy subjects and patients with pharyngeal dysphagia. Informed consent was obtained from 15 healthy men and 4 patients with pharyngeal dysphagia. Digastric and stylohyoid muscles were stimulated by silver-textile surface electrodes covering the muscle belly. Laryngeal elevation by the electrical stimulation(ES) during liquid(water, 3ml) swallowing movement was measured by digital video camera. Laryngeal elevation by ES was 76% in the healthy subjects and 87% in patients when measured during liquid swallowing. Applying FES for laryngeal elevation may assist in improving the swallowing reflex.
|
Report
(4 results)
Research Products
(72 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Relationship between Penetration-Aspiration Scale : PAS and Dysphagia Severity Scale : DSS2012
Author(s)
Itoh Y, Ota K, Kagaya H, Inamoto Y, Shibata S, Aoyagi Y, Onogi K, Tanaka T, Hamada F, Kanamori D, Okada T, Saitoh E
Year and Date
2012-03-17
Related Report
-
-
-
[Presentation] Changes in the length of individual suprahyoid and infrahyoid muscles during swallowing : analysis using 3D dynamic computed tomography2012
Author(s)
Okada T, Aoyagi Y, Inamoto Y, Saitoh E, Shibata S, Kagaya H, Ota K, Ito Y, Fujii N, Katada K
Organizer
12th Annual Dysphagia Research Society, Annual Meeting
Place of Presentation
The Ritz-Carlton, Toronto, Canada
Related Report
-
[Presentation] Activities of superior and middle pharyngeal constrictor muscles during swallowing : analysis using 3D dynamic computed tomography2012
Author(s)
Aoyagi Y, Okada T, Inamoto Y, Saitoh E, Shibata S, Kagaya H, Ota K, Ito Y, Fujii N, Katada K
Organizer
12th Annual Dysphagia Research Society, Annual Meeting
Place of Presentation
The Ritz-Carlton, Toronto, Canada
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Rehabilitation approaches to improve pharyngeal dysphagia : electrical stimulation and botulinum toxin type A injection(咽頭期嚥下障害に対するリハビリテーションアプローチ-電気刺激とボツリヌス毒素注入療法-)2010
Author(s)
青柳陽一郎, 久野弘明, 山本敏泰, 嘉村雄飛, 目谷浩通, 平岡崇, 清水五弥子, 山口若水, 山下都, 中武恵子, 畠二郎, 椿原彰夫
Organizer
第1回ニューロリハビリテーション学会,エーザイ名古屋コミュニケーションオフィス
Place of Presentation
名古屋市
Year and Date
2010-01-30
Related Report
-
-
-
-
[Presentation] 超音波装置による上部食道運動機能評価健常人における検討2010
Author(s)
筒井英明, 青柳陽一郎, 畠二郎, 眞部紀明, 今村祐志, 楠裕明, 山下直人, 石井学, 椿原彰夫, 春間賢
Organizer
第16回日本摂食・嚥下リハビリテーション学会
Place of Presentation
朱鷺メッセ,新潟
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-