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The improving effect of the redox capacity control upon maintainace hemodialysis patietnts' disability of locomotive function.

Research Project

Project/Area Number 21500532
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionFujita Health University

Principal Investigator

OHASHI Atsushi  藤田保健衛生大学, 医療科学部, 准教授 (30310585)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Kazutaka  藤田保健衛生大学, 医学部, 講師 (30267950)
中井 滋  藤田保健衛生大学, 医療科学部, 教授 (20345896)
杉山 敏  藤田保健衛生大学, 医学部, 教授 (50340229)
Co-Investigator(Renkei-kenkyūsha) NAKAI Shigeru  藤田保健衛生大学, 医療科学部, 教授 (20345896)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体機能代行 / 抗酸化物質 / ラジカル捕捉活性 / 酸化ストレス / 血液透析 / 運動障害 / QOL評価 / 酸化修飾代謝物質 / 維持透析 / 運動機能障害
Research Abstract

Firstly we investigated inhibition effect of the emodialysis using vitamin E-coated polysulfone membrane(VPS-HD) to the carbonylation of patients' plasma protein. Secondary we evaluated its influence on patients' health-rerated quality of life(HQOL) using SF-36.VPS-HD suppressed the carbonylation of their serum albumin, but not improve albumin's redox capacity. However VPS-HD gave no significant effect to physical functioning(PF), bodily pain(BP) or vitality(VT) of patient's HQOL, it significantly improved general healthy perceptions(GH). In addition, we found marginally significant positive correlation between its improvement of GH and its inhibition for serum albumin modification. These findings may suggest that VPS-HD ameliorates patient's GH throgh patietnt's redox capacity improvement.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Comparison of Free Light Chain Removal by Four Blood Purification Methods2011

    • Author(s)
      Kanayama K, Ohashi A, Hasegawa M, Kondo F, Yamamoto Y, Sasaki M, Hayashi H, Kato K, Hattori R, Yamashita H, Arai J, Ishii J, Emi N, Yuzawa Y
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 15(4) Pages: 394-399

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of blood purification and bortezomib plus dexamethasone therapy for the treatment of acute renal failure due to myeloma cast nephropathy2010

    • Author(s)
      Hasegawa M, Kondo F, Yamamoto K, Murakami K, Tomita M, Nabeshima K, Nakai S, Kato M, Ohashi A, Arai J, Hiki Y, Ishi J, Emi N, Sugiyama S, Yuzawa Y
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 14(5) Pages: 451-456

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ニプロ社製ダイアライザーPES-Seαecoの溶質除去特性とビスフェノールAの溶出に関する検討2010

    • Author(s)
      新典雄、村上和隆、石川正敏、橋詰英明、山田幸恵、加藤政雄、大橋篤、杉山敏
    • Journal Title

      腎と透析

      Volume: Vol.69 Pages: 87-91

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression of Tumor Necrosis Factor Receptors on Granulocytes in Patients with Myeloperoxidase Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis2009

    • Author(s)
      Hasegawa M, Nishii C, Ohashi A, Tomita M, Nakai S, Murakami K, Nabeshima K, Fujita Y, Ishii J, Hiki Y, Sugiyama S
    • Journal Title

      Nephron Clin Pract

      Volume: 113(3) Pages: 222-233

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An Overview of Regular Dialysis Treatment in Japan2009

    • Author(s)
      Shigeru Nakai
    • Journal Title

      Therapeutic Apheresis and Dialysis 13(6)

      Pages: 457-504

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 透析患者の血漿成分におけるDPPHラジカル捕捉能と酸化/還元型アルブミンによる抗酸化能の動態2010

    • Author(s)
      大橋篤, 堀秀生, 川口和紀, 中井滋, 北口暢哉, 比企能之, 村上和隆, 鍋島邦浩, 富田亮, 長谷川みどり, 杉山敏
    • Organizer
      日本透析医学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 透析患者の血漿成分におけるDPPHラジカル捕捉能と酸化/還元型アルブミンによる抗酸化能の動態2010

    • Author(s)
      大橋篤
    • Organizer
      第54回 日本透析医学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 維持透析患者における血清成分の窒素ラジカル供与物質に対する抗酸化能の評価2009

    • Author(s)
      大橋篤, 堀秀生, 中井滋, 村上和隆, 杉山敏
    • Organizer
      日本透析医学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 維持透析患者における血清成分の窒素ラジカル供与物質に対する抗酸化能の評価2009

    • Author(s)
      大橋篤
    • Organizer
      第53回 日本透析医学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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