| Project/Area Number |
21500532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Fujita Health University |
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Principal Investigator |
OHASHI Atsushi 藤田保健衛生大学, 医療科学部, 准教授 (30310585)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Kazutaka 藤田保健衛生大学, 医学部, 講師 (30267950)
中井 滋 藤田保健衛生大学, 医療科学部, 教授 (20345896)
杉山 敏 藤田保健衛生大学, 医学部, 教授 (50340229)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAI Shigeru 藤田保健衛生大学, 医療科学部, 教授 (20345896)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 生体機能代行 / 抗酸化物質 / ラジカル捕捉活性 / 酸化ストレス / 血液透析 / 運動障害 / QOL評価 / 酸化修飾代謝物質 / 維持透析 / 運動機能障害 |
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| Research Abstract |
Firstly we investigated inhibition effect of the emodialysis using vitamin E-coated polysulfone membrane(VPS-HD) to the carbonylation of patients' plasma protein. Secondary we evaluated its influence on patients' health-rerated quality of life(HQOL) using SF-36.VPS-HD suppressed the carbonylation of their serum albumin, but not improve albumin's redox capacity. However VPS-HD gave no significant effect to physical functioning(PF), bodily pain(BP) or vitality(VT) of patient's HQOL, it significantly improved general healthy perceptions(GH). In addition, we found marginally significant positive correlation between its improvement of GH and its inhibition for serum albumin modification. These findings may suggest that VPS-HD ameliorates patient's GH throgh patietnt's redox capacity improvement.
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