Satellite cell activation to the change of muscle fiber size and the effects of motor nerve innervations and aging

• Project/Area Number: 21500633
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Kumamoto University
• Principal Investigator: OISHI Yasuharu 熊本大学, 教育学部, 准教授 (10203704)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 熱ストレス / 再生筋線維 / 衛星細胞 / ミオシン重鎖 / ヒラメ筋 / ラット / 速筋線維 / 遅筋線維 / heat shock protein / 筋線維組成 / 速筋型ミオシン重鎖 / 遅筋型ミオシン重鎖 / Myo D

Research Abstract

Analyses were performed on the fiber phenotype expression, satellite cell activation, and the effects of heat stress at an early stage of rat soleus fiber regeneration. In heat stressed soleus regenerating fibers, slow type fiber containing only the slow myosin heavy chain isoform and enhanced activation of satellite cells were observed. These results suggest the possibility that heat stress accelerates the shift of fiber phenotype from fast to slow at an early stage of soleus fiber regenerating process.

Research Products

• [Journal Article] Fasting-related autophagic response in slow-and fast-twitch skeletal muscle (2010)
  • Author(s): Ogata T., Oishi Y., Higuchi M. and Muraoka I.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 394 Pages: 136-140
  • Peer Reviewed
• [Journal Article] Fasting-related autophagic response in slow- and fast-twitch skeletal muscle (2010)
  • Author(s): Ogata T., Oishi Y., et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 394 Pages: 136-140
  • Peer Reviewed
• [Journal Article] Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers (2009)
  • Author(s): Oishi Y., Hayashida M., Tsukiashi S., Taniguchi K., Kami K., Roy R. R. and Ohira Y.
  • Journal Title: Journal of Applied Physiology Volume: 107 Pages: 1612-1621
  • Peer Reviewed
• [Journal Article] Prolonged exercise training induces long-term enhancement of HSP70 expression in rat plantaris muscle (2009)
  • Author(s): Ogata T., Oishi Y., Higashida K., Higuchi M. and Muraoka I.
  • Journal Title: American Journal of Physiology-Regulatory Integrative and Comparative Physiology Volume: 296
  • Peer Reviewed
• [Journal Article] Differential cell death regulation between adult-unloaded and aged rat soleus muscle (2009)
  • Author(s): Ogata T., Machida S., Oishi Y., Higuchi M. and Muraoka I.
  • Journal Title: Mechanisms of Ageing and Development Volume: 130 Pages: 328-336
  • Peer Reviewed
• [Journal Article] Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers (2009)
  • Author(s): Oishi Y, et al.
  • Journal Title: J Appl Physiol 107 Pages: 1612-1621
  • Peer Reviewed
• [Journal Article] Prolonged exercise training induces long-term enhancement of HSP70 expression in rat plantaris muscle (2009)
  • Author(s): Ogata T, Oishi Y, et al.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 296
  • Peer Reviewed
• [Journal Article] Differential cell death regulations between adult-unloaded and aged ratsoleus muscle (2009)
  • Author(s): Ogata T, Oishi Y, et al.
  • Journal Title: Mech Ageing Dev 130 Pages: 328-336
  • Peer Reviewed
• [Presentation] 絶食に伴う筋委縮に対する代償性過負荷の影響 (2011)
  • Author(s): 緒方知徳、大石康晴
  • Organizer: 第66回日本体力医学会
  • Place of Presentation: 海峡メッセ下関、下関市、山口県
  • Year and Date: 2011-09-18
• [Presentation] 絶食に伴う筋委縮に対する代償性過負荷の影響 (2011)
  • Author(s): 緒方知徳、大石康晴
  • Organizer: 第66回日本体力医学会
  • Place of Presentation: 海峡メッセ下関、下関市、山口
  • Year and Date: 2011-09-18
• [Presentation] Heat stress enhances fiber size increment via satellite cell activation in rat regenerating soleus fibers (2010)
  • Author(s): Yasuharu Oishi, Mari Hayashida, Roland R. Roy, Yoshinobu Ohira
  • Organizer: Experimental Biology 2010, Anaheim Convention Center
  • Place of Presentation: Anaheim, CA, USA
• [Presentation] Heat stress enhances fiber size increment via satellite cell activation in rat regenerating soleus fibers. (2010)
  • Author(s): Oishi Y., et al.
  • Organizer: Experimental Biology
  • Place of Presentation: Anaheim Convention Center, Anaheim, CA, USA
• [Presentation] 絶食に伴うラット骨格筋内オートファジーの誘導と制御 (2009)
  • Author(s): 緒方知徳、大石康晴、村岡功
  • Organizer: 第64回日本体力医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-20
• [Presentation] Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers (2009)
  • Author(s): Yasuharu Oishi, Mari Hayashida, Shinsuke Tsukiashi, Kohachi Taniguchi, Katsuya Kami, Roland R. Roy and Yoshinobu Ohira
  • Organizer: International Symposium "Nueromuscular Regeneration"
  • Place of Presentation: Kyoto University, Kyoto, Japan
  • Year and Date: 2009-07-30
• [Presentation] Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers (2009)
  • Author(s): Oishi Y, et al.
  • Organizer: International Symposium for "Nueromuscular Regeneration"
  • Place of Presentation: Kyoto University
  • Year and Date: 2009-07-30
• [Book] Muscle Cell Physiology. Edt. Section 5 : Calcineurin signaling pathways in mammalian skeletal muscles (2009)
  • Author(s): Yasuharu Oishi
  • Publisher: Osaka University Press
• [Book] 「Muscle Cell Physiology」Section 5 : Calcineurin (2009)
  • Author(s): Oishi Yasuharu
  • Total Pages: 136
  • Publisher: Osaka University Press