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Basic studies on high-altitude training : Chemoreceptor mechanism on spontaneously hypertensive rats(SHR) in chronic hypoxia

Research Project

Project/Area Number 21500636
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionKokushikan University

Principal Investigator

KUSAKABE Tatsumi  国士舘大学, 体育学部, 教授 (80117663)

Co-Investigator(Kenkyū-buntansha) MATUDA Hideki  横浜市立大学, 医学部, 准教授 (80305458)
YAMAMOTO Yoshio  岩手大学, 農学部, 教授 (10252123)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords高地トレーニング / 低酸素 / 高血圧 / 化学受容器 / ノルアドレナリン / 頸動脈小体 / SHR / 免疫組織化学 / カテコラミン合成酵素 / ノルアドレナリン合成酵素 / 神経ペプチド
Research Abstract

The carotid bodies, which are located at the carotid bifurcation and are the primary organs for sensing changes in arterial blood gases, became significantly enlarged in spontaneously hypertensive animals(SHR). In spite of enlargement, there was no obvious vascular enlargement in SHR. SHR showed a significant increase in extracellular matrix in the carotid body. These indicate that the mechanism of carotid body enlargement in SHR is different from that in hypoxic animals. In addition, the present studies suggest facilitated noradrenaline biosynthesis in chemoreceptor cells of carotid bodies in SHR.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (8 results) Book (3 results)

  • [Journal Article] Total volume of caroti body and dopamineβ-hydroxilase immunorectivity of glomus cells in spontaneously hypertensive rats2012

    • Author(s)
      K. Kato, J. Wakai, H. Matsuda, T. Kusakabe, Y. Yamamoto
    • Journal Title

      Auton. Neurosci

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total volume of carotid body and dopamine β-hydroxilase immunoreactivity of glomus cells in spontaneously hypertensive rats2012

    • Author(s)
      K.Kato, et al
    • Journal Title

      Auton.Neurosci.

      Volume: 26(In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mor phological characteristics and peptidergic innervation in the carotid body of spontaneoously hypertensive rats(SHR)2011

    • Author(s)
      M. Takahashi, H. Matsuda, Y. Hayashida, Y. Yamamoto, M. Tsukuda, T. Kusakabe
    • Journal Title

      Histol. Histopathol

      Volume: 26 Pages: 369-375

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological development and expression of neurotrophin receptors in the laryngeal sensory corpuscles2011

    • Author(s)
      Y.Yamamoto, et al
    • Journal Title

      Anat.Rec.

      Volume: 294 Pages: 694-705

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological characteristics and peptidergic innervations in tha carotid body of spontaneously hypertensive rats.2011

    • Author(s)
      M.Takahashi, et., al.
    • Journal Title

      Histol.Histopathol.

      Volume: 26 Pages: 369-375

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Examination of the optimal condition on the in vitro sensitivity to telomelysin in head and neck cancer cell lines.2011

    • Author(s)
      A.Sakakibara, et al.
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Pages: 589-599

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shortterm hypoxia increases tyrosine hydroxylase immunoreactivity in rat carotid body2010

    • Author(s)
      K. Kato, M. Yamaguchi-Yamada, Y. Yama moto
    • Journal Title

      J. Histochem. Cytochem

      Volume: 58 Pages: 839-846

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in tyrosine hydroxylase expression after shortterm hypoxia, hypercapnia or hypercapnic hypoxia in rat carotid body2010

    • Author(s)
      J. Wakai, K. Kizaki, M. Yamaguchi-Yamada, Y. Yamamoto
    • Journal Title

      Respir. Physiol. Neurobiol

      Volume: 173 Pages: 95-100

    • NAID

      120002439246

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short-term hypoxia increases tyrosine hydroxylase immunoreactivity in rat carotid body.2010

    • Author(s)
      K.Kato, et., al.
    • Journal Title

      J.Histochem.Cytochem.

      Volume: 58 Pages: 839-846

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in tyrosine hydroxylase expression after short-term hypoxia, hypercapnia or hypercapnic hypoxia in rat carotid body.2010

    • Author(s)
      J.Wakai, et., al.
    • Journal Title

      Resp.Physiol.Neurobiol.

      Volume: 173 Pages: 95-100

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological characteristics and peptidergic innervations in tha carotid body of spontaneously hypertensive rats2010

    • Author(s)
      M.Takahashi, et., al.
    • Journal Title

      Histol.Histopathol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of telemelysin in combination with pacritaxel or cisplatin on head and neck squamous cell cartinoma2010

    • Author(s)
      N.Kondo, et., al.
    • Journal Title

      Oncol.Rep. 23

      Pages: 355-363

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased rate of force development of elbow flexors by antagonist conditioning contraction2009

    • Author(s)
      T.Kamimura, et., al.
    • Journal Title

      Human Movement Sci. 28

      Pages: 407-414

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット頚動脈小体におけるセロトニン合成・分泌関連分子の発現2011

    • Author(s)
      横由拓也, 他
    • Organizer
      第151回日本獣医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動脈系化学受容器の内因性および外因性環境変化に対する適応2011

    • Author(s)
      日下部辰三、高橋優宏、松田秀樹、加藤剛、山本欣郎、林田嘉朗
    • Organizer
      第88回日本生理学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 舌・化学受容器に対する内因性および外因性環境変化の影響2011

    • Author(s)
      林田嘉朗、松田秀樹、山本欣郎、川上倫、竹中敏文、日下部辰三
    • Organizer
      第116回日本解剖学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 高血圧自然発症ラットの頚動脈小体グロムス細胞におけるドーパミンβ-水酸化酵素免疫反応性の増強2011

    • Author(s)
      加藤剛、日下部辰三、松田秀樹、山口-山田美鈴、林田嘉朗、山本欣郎
    • Organizer
      第116回日本解剖学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 低酸素暴露および高血圧による頸動脈小体肥大の比較2010

    • Author(s)
      松田秀樹, 他
    • Organizer
      第115回日本解剖学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素暴露および高血圧による頚動脈小体肥大の比較2010

    • Author(s)
      松田秀樹、林田嘉朗、川上倫、竹中敏文、日下部辰三
    • Organizer
      第115回日本解剖学会
    • Place of Presentation
      盛岡
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット頚動脈小体におけるセロトニン合成・分泌関連分子の発現2010

    • Author(s)
      横山 拓也、松田 秀樹、日下部 辰三、山田 美鈴、山本 欣郎
    • Organizer
      第151 回日本獣医学会
    • Place of Presentation
      第151 回日本獣医学会
    • Related Report
      2011 Final Research Report
  • [Presentation] 高血圧自然発症ラット(SHR)の舌味蕾におけるcalbindin D-28k免疫活性2009

    • Author(s)
      松田秀樹、林田嘉朗、川上倫、竹中敏文、日下部辰三
    • Organizer
      第114回日本解剖学会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Book] The amphibian carotid labyrinth2010

    • Author(s)
      T. Kusakabe
    • Publisher
      Plymous UK
    • Related Report
      2011 Final Research Report
  • [Book] Arterial chemoreceptors in the vertebrates.2010

    • Author(s)
      T.Kusakabe
    • Total Pages
      527
    • Publisher
      Science Publishers
    • Related Report
      2010 Annual Research Report
  • [Book] Arterial chemoreceptors in the vertebrates2010

    • Author(s)
      T.Kusakabe
    • Total Pages
      527
    • Publisher
      Science Publishers
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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