Effects of microcurrent electrical neuromuscular stimulation on the regeneration of injured muscles-immunohistochemical approaches-
| Project/Area Number |
21500639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
FUJIYA Hiroto 聖マリアンナ医科大学, 医学部, 講師 (50278008)
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Katsumasa 豊橋創造大学, 保健医療学部, 教授 (70239961)
OGURA Yuji 聖マリアンナ医科大学, 医学部, 助教 (90509952)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 微弱電流 / 筋損傷 / 骨格筋 / 生理学 |
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| Research Abstract |
In the present study, the effect of microcurrent electrical neuromuscular stimulation(MENS) on the regeneration of injured mice skeletal muscles by using of immunohistochemical approaches. MENS stimulated the increases of muscle protein content, fiber diameter, satellite cells, and muscle cells having central nucleus during the regenerating phase. The mean expression levels of phosphorylation of Akt、p70 S6 kinase and p38 mitogen-activated protein kinase during the regenerating phase of injured skeletal muscle were up-regulated by MENS. These results strongly suggest that MENS may facilitate the regeneration of injured muscles via both the stimulation of muscle protein synthesis and the activation of muscle satellite cells.
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Report
(4 results)
Research Products
(13 results)
