| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
In the present study, the effect of microcurrent electrical neuromuscular stimulation(MENS) on the regeneration of injured mice skeletal muscles by using of immunohistochemical approaches. MENS stimulated the increases of muscle protein content, fiber diameter, satellite cells, and muscle cells having central nucleus during the regenerating phase. The mean expression levels of phosphorylation of Akt、p70 S6 kinase and p38 mitogen-activated protein kinase during the regenerating phase of injured skeletal muscle were up-regulated by MENS. These results strongly suggest that MENS may facilitate the regeneration of injured muscles via both the stimulation of muscle protein synthesis and the activation of muscle satellite cells.
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