The mechanism of exercise-induced increase in insulin sensitivity : Effect of exercise on NR4A receptor gene expression

• Project/Area Number: 21500640
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: KAWANAKA Kentaro 新潟医療福祉大学, 健康科学部, 准教授 (80339960)
• Co-Investigator(Renkei-kenkyūsha): TERADA Shin 早稲田大学, 付置研究所, 講師 (00460048)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 骨格筋 / インスリン感受性 / 遺伝子 / NR4A3 / NOR-1 / 高脂肪食 / NR4A1 / Nur77 / 運動 / 不活動 / 交感神経 / 水泳 / トレッドミル / AMPK / AICAR

Research Abstract

Exercise increases insulin sensitivity of glucose transport in skeletal muscle. Our study aimed to examine the possibility that exercise-induced increase in insulin sensitivity is mediated by the increased expression of NR4A receptors in skeletal muscle. However, this possibility is unlikely since exercise increased NR4A mRNA but not protein expression in rat skeletal muscle. On the other hand, our study showed that hindlimb immobilization decreased NR4A protein expression in rat postural muscle, suggesting the possibility that inactivity-induced insulin resistance is mediated by the reduced expression of NR4A receptors.

Research Products

• [Journal Article] The effects of beta-adrenergic stimulation and exercise on NR4A3 protein expression in rat skeletal muscle (2011)
  • Author(s): Kawasaki, E., Hokari, F., Sasaki, M., Sakai, A., Koshinaka, K., and K. Kawanaka
  • Journal Title: J. Physiol. Sci Volume: 61 Issue: 1 Pages: 1-11
  • DOI: 10.1007/s12576-010-0114-y
• [Journal Article] The effects of beta-adrenergic stimulation and exercise on NR4A3 protein expression in rat skeletal muscle. (2011)
  • Author(s): Kawasaki, E., Hokari, F., Sasaki, M., Sakai, A., Koshinaka, K., K.Kawanaka
  • Journal Title: J.Physiol.Sci. Volume: 61 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Role of local muscle contractile activity in the exercise-induced increase in NR4A receptors mRNA expression (2009)
  • Author(s): Kawasaki, E., Hokari, F., Sasaki, M., Sakai, A., Koshinaka, K., and K. Kawanaka
  • Journal Title: J. Appl. Physiol Volume: 106 Pages: 1826-1831
  • URL: http://www.jap.org
• [Journal Article] Role of local muscle contractile activity in the exercise-induced increase in NR4A receptors mRNA expression. (2009)
  • Author(s): Kawasaki, E., Hokari, F., Sasaki, M., Sakai, A., Koshinaka, K., K.Kawanaka
  • Journal Title: J.Appl.Physiol. 106 Pages: 1826-1831
  • Peer Reviewed
• [Presentation] 事前の単発運動が不活動誘発性骨格筋インスリン抵抗性に及ぼす影響 (2011)
  • Author(s): 川崎絵美, 阿部夏希, 越中敬一, 川中健太郎
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 山口・海峡メッセ下関
  • Year and Date: 2011-09-17
• [Presentation] 運動による糖尿病予防効果の機序 (2011)
  • Author(s): 川中健太郎
  • Organizer: 第51回澱粉研究懇談会
  • Place of Presentation: 兵庫・有馬温兵衛向陽閣
  • Year and Date: 2011-06-04
• [Presentation] 異なるタイプの運動が骨格筋糖代謝に及ぼす影響 (2011)
  • Author(s): 川中健太郎
  • Organizer: 第19回スポーツ栄養学研究会
  • Place of Presentation: 東京・お茶の水女子大
  • Year and Date: 2011-05-14
• [Presentation] 不活動は遺伝子発現の増加を介して骨格筋のインスリン抵抗性を引き起こす (2010)
  • Author(s): 川崎絵美、川中健太郎
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉商科大学
  • Year and Date: 2010-09-17
• [Presentation] 運動および不活動が核内受容体NR4A3タンパク質発現に及ぼす影響 (2009)
  • Author(s): 川崎絵美, ら
  • Organizer: 日本体力医学会
  • Place of Presentation: 新潟コンベンションセンター
  • Year and Date: 2009-09-19
• [Presentation] 運動が骨格筋における核内受容体NR4A3遺伝子発現に及ぼす影響 (2009)
  • Author(s): 川中健太郎, 川崎絵美
  • Organizer: 第9回新潟医療福祉学会学術集会
  • Place of Presentation: 新潟
• [Presentation] 運動および不活動が核内受容体NR4A3タンパク質発現に及ぼす影響 (2009)
  • Author(s): 川崎絵美, 保苅芙美, 酒井篤, 川中健太郎
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟
• [Presentation] ギブス固定がラットヒラメ筋の糖取り込みに及ぼす影響 (2009)
  • Author(s): 川崎絵美, 酒井篤, 川中健太郎
  • Organizer: 第17回日本運動生理学会
  • Place of Presentation: 東京
• [Book] スポーツ現場に生かす運動生理・生化学 (2011)
  • Author(s): 樋口満、川中健太郎, 他15名
  • Total Pages: 174
  • Publisher: 市村出版