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Analysis of the effects of the nutritional composition on obesity, glucose and lipid metabolism, and atherosclerosis

Research Project

Project/Area Number 21500678
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionUniversity of Tsukuba

Principal Investigator

SUZUKI Hiroaki  筑波大学, 医学医療系, 准教授 (40344890)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Akimitsu  筑波大学, 医学医療系, 准教授 (70344893)
YATO Shigeru  筑波大学, 医学医療系, 講師 (50451703)
KOBAYASHI Kazuto  筑波大学, 医学医療系, 講師 (30455935)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生活習慣病 / 糖尿病 / 脂質異常症 / 肥満 / 食事療法 / 頸動脈硬化
Research Abstract

The effects of staple foods on the postprandial hyperglycemia and hyperlipidemia differed between rice and white bread in patients with type 2 diabetes. Eating white rice significantly raised postprandial glucose level in comparison with eating white bread. On the other hand, eating white bread significantly raised postprandial triglycerides level more than eating white bread. These data suggest that source of carbohydrate affect not only postprandial glucose level but also postprandial hyperlipidemia.
Intima-media thickness (IMT) in carotid ultrasound could predict coronary artery disease detected by coronary CT angiography. There was no association between coronary artery plaque and serum fatty acid composition, although sample size of this study was small. A prospective study in large sample size is needed to investigate the relationship between coronary artery disease and serum fatty acid composition.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011

All Presentation (8 results)

  • [Presentation] フラミンガムリスクスコア、UKPDSリスクエンジン、max-IMT、LDL/HDL 比による冠動脈病変予測能に関する検討2012

    • Author(s)
      藤原和哉, 鈴木浩明, 佐藤明, 大崎芳典, 尾本美代子, 豊崎晶子, 平安座依子, 児玉暁, 齋藤和美, 小林和人, 高橋昭光, 矢藤繁, 山田信博, 曽根博仁, 島野仁
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of serumlipid level on number of vulnerable coronary plaque (VP) detected by CT angiography (CTA) in asymptomatic patients with type 2 diabetes (T2DM)2011

    • Author(s)
      Kazuya Fujihara, Hiroaki Suzuki, AkiraSato, Tomoko Ishizu, Yoriko Heianza, Satoru Kodama, Kazumi Saito, Kazuto Kobayashi, Shigeru Yato, Akimitsu Takahasi, Nobuhiro Yamada, Hirohito Sone, Hitoshi Shimano
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of serum lipid level on number of vulnerable coronary plaque (VP) detected by CT angiography (CTA) in asymptomatic patients with type 2 diabetes (T2DM)2011

    • Author(s)
      Fujihara Kazuya
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of Clinical Predictors of Vulnerable Coronary Plaque Detected by CT Angiography in Asymptomatic Patients with type 2 Diabetes (T2DM)2011

    • Author(s)
      Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Yoriko Heianza, Satoru Kodama, Kazumi Saito, Kazuto Kobayashi, Akimitsu Takahashi, Shigeru Yatou, Nobuhiro Yamada, Hirohito Sone, Hitoshi Shimano
    • Organizer
      71st scientific sessions of American Diabetes Association, San Diego, USA
    • Year and Date
      2011-06-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of clinical predictors of vulnerable coronary plaque detected by CT angiography in asymptomatic patients with type 2 diabetes (T2DM)2011

    • Author(s)
      Fujihara Kazuya
    • Organizer
      71st Scientific Sessions, American Diabetes Association
    • Place of Presentation
      San Diego Convention Center (USA)
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] CT coronary angiography (CTA)による冠動脈不安定プラーク(VP)と関連する臨床指標に関する検討2011

    • Author(s)
      藤原和哉, 鈴木浩明, 佐藤明, 大崎芳典, 尾本美代子, 豊崎晶子, 平安座依子, 児玉暁, 斎藤和美, 小林和人, 矢藤繁, 高橋昭光, 山田信博, 曽根博仁, 島野仁
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] CT coronary angiography(CTA)こよる冠動脈不安定プラーク(VP)と関連する臨床指標に関する検討2011

    • Author(s)
      藤原和哉
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌プリンスホテル(北海道)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖尿病患者の血中脂質管理におけるnonHDLコレステロールの有用性2011

    • Author(s)
      島野仁, 藤原和哉, 岩崎仁, 小林和人, 矢藤繁, 高橋昭光, 鈴木浩明, 山田信博
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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