血液凝固線溶系を指標とした幼児期からのメタボリックシンドロームの予防に関する研究

• Project/Area Number: 21500680
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: HORIGOME Hitoshi 筑波大学, 医学医療系, 准教授 (50241823)
• Co-Investigator(Kenkyū-buntansha): KAMODA Tomohiro 筑波大学, 医学医療系, 准教授 (50224704)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: メタボリックシンドローム / 小児肥満症 / 血液凝固線溶系 / アディポカイン / 血管内皮機能 / 小児 / 肥満 / アデイポカイン

Research Abstract

The metabolic syndrome is considered to originate in fetal life through childhood. In this study, we established the metabolic syndrome related hematological reference values, including adipokines and hemostatic/fibrinolytic systems, in Japanese children. These parameters are associate with BMI and central obesity, and strongly correlate to uric acid(UA), leptin and fibrinogen. This study suggests that changes in adipokines and hemostatic/fibrinolytic systems during early childhood contribute to the development of metabolic syndrome.

Research Products

• [Journal Article] Significant associations amonghemostatic parameters, adipokines, and components of the metabolic syndrome in Japanese preschool children (2012)
  • Author(s): Horigome H, Katayama Y, Yoshinaga M et al.
  • Journal Title: Clinical and Applied Thrombosis/Hemostasis Volume: 18 Issue: 2 Pages: 189-94
  • DOI: 10.1177/1076029611418962
  • Peer Reviewed
• [Journal Article] Determinants of blood rheology in healthy adults and children using the microchannel array flow analyzer (2010)
  • Author(s): Katayama Y, Horigome H, Takahashi H, Tanaka K, Yoshinaga M.
  • Journal Title: Clinical and Applied Thrombosis/Hemostasis Volume: 16 Pages: 414-421
  • Peer Reviewed
• [Journal Article] Prevalence of childhood obesity from 1978 to 2007 in Japan (2010)
  • Author(s): Yoshinaga M, Ichiki T, Tanaka Y, Hazeki D, Horigome H, Takahashi H, Kashima K.
  • Journal Title: Pediatrics International Volume: 52 Pages: 213-217
  • NAID: 10028181768
  • Peer Reviewed
• [Journal Article] Isolation of pulmonary vein and superior vena cava for paroxysmal atrial fibrillation in a young adult with left ventricular non- (2010)
  • Author(s): Kato Y, Horigome H, Takahashi-Igari M, Yoshida K, Aonuma K
  • Journal Title: EUROPACE Volume: 12 Pages: 1040-1041
  • Peer Reviewed
• [Journal Article] Blood rheology and its determinantsin healthy adults and children using the Microchannel Array Flow Analyzer (2009)
  • Author(s): Katayama Y, Horigome H, Takahashi H
  • Journal Title: Clinical and Applied Thrombosis/Hemostasis Volume: 24
• [Journal Article] Prevalence of childhood obesity from 1978 to 2007 in Japan (2009)
  • Author(s): Yoshinaga M, Ichiki T, Tanaka Y, Hazeki D, Horigome H et al
  • Journal Title: Pediatric International Volume: 20
  • NAID: 10028181768
• [Journal Article] Blood Rheology and its Determinants in Healthy Adults and Children Using the Microchannel Array Flow Analyzer. (2009)
  • Author(s): Katayama Y, Horigome H, Takahashi H, Tanaka K, Yoshinaga M
  • Journal Title: Clinical and Applied Thrombosis/Hemostasis 24(E-pub)
  • Peer Reviewed
• [Journal Article] Prevalence of childhood obesity from 1978 to 2007 in Japan. (2009)
  • Author(s): Yoshinaga M, Ichiki T, Tanaka Y, Hazeki D, Horigome H, et al.
  • Journal Title: Pediatric International 20(E-pub)
  • NAID: 10028181768
  • Peer Reviewed
• [Journal Article] Successful pregnancy in a female patient with congenital chloride diarrhea(CLD) and renal impairment (2009)
  • Author(s): Shimizu Y, Kamoda T, Nagata M, et al.
  • Journal Title: Journal of Nephrology 22 Pages: 809-813
  • Peer Reviewed
• [Presentation] 学童における心血管系危険因子としての可溶性トロンボモジュリンとレプチン (2010)
  • Author(s): 堀米仁志
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-04-23
• [Presentation] 学童における心血管系危険因子としての可溶性トロンボモジュリンとレプチン (2010)
  • Author(s): 片山靖富, 加藤愛章, 高橋実穂, 鴨田知博, 吉永正夫, 須磨崎亮
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-23
• [Book] 小児循環器疾患における血栓症 (2011)
  • Author(s): 堀米仁志
  • Total Pages: 6
  • Publisher: メディカルレビュー社
• [Book] 小児循環器疾患における血栓症、Fetal & Neonatal Medicine (2011)
  • Author(s): 堀米仁志
  • Total Pages: 6
  • Publisher: メディカルレビュー社
• [Book] メタボリックシンドロームと血栓、小児科臨床ピクシス6(五十嵐隆総編集)、小児メタボリックシンドローム(大関武彦編) (2009)
  • Author(s): 堀米仁志
  • Total Pages: 4
  • Publisher: 中山書店