| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
To investigate the effects of low intensity vibration on the enzyme activities and the gene expression for both bone absorption and formation, we cultivated neonatal mouse calvaria as human bone model. Mice calvaria treated with 0. 5-and 2. 0-G vibrational acceleration showed a significant inhibition of osteoclast enzyme activity and an increase of expression of type I collagen. We also found that slow walking generates 0. 5-G or more acceleration at the waist. Therefore, our results suggested that not only high-intensity strength exercises such as jumping, but frequent walking can decrease bone absorption activity in the weight bearing bone of the waist in elderly.
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