Molecular mechanisms of glucose metabolism induced by stretch in skeletal muscles.
Project/Area Number |
21500687
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied health science
|
Research Institution | University of Shizuoka |
Principal Investigator |
OBARA Kazuo 静岡県立大学, 薬学部, 講師 (60117611)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 骨格筋 / 糖代謝 / ストレッチ / インテグリン / カルシウム / GLUT4 / CaMKII / FAK / L6細胞 / 三次元培養 / NOS / シグナル伝達 / マウスヒラメ筋 / Akt / PI3K / カベオリン3 |
Research Abstract |
Mechanism of glucose uptake induced by passive stretch stimulation(stretch) in skeletal muscle was investigated. Our results suggest that stretch is accepted by integrin/FAK and causes Ca^<2+> release from sarcoplasmic reticulum, resulting increase in glucose uptake through CaMKII activation. Our results also suggest that stretch-induced glucose uptake involves insulin-and contraction-independent pathways.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article]2009
Author(s)
Koichi Nakayama
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Journal Title
Mechanosensitivity in Cells and Tissues 3. Mechanosensitivity of the Heart(Springer)
Pages: 453-481
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