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Applied research on the relationship between bacterial/viral infections and reduction of exercise performance

Research Project

Project/Area Number 21500700
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionKawasaki University of Medical Welfare

Principal Investigator

YANO Hiromi  川崎医療福祉大学, 医療技術学部, 准教授 (20248272)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords病原体関連分子 / TLRs / 疲労困憊運動 / 自発運動 / マウス / マクロファージ / サイトカイン / 腸管上皮細胞 / フラジェリン / poly I:C / R-848
Research Abstract

We have shown that protection against bacterial and/or viral infections is inhibited by an intense exercise, and physical activity is inhibited by the immune defense function after infection. Immunosuppression due to the intense exercise is a reasonable reaction defense to minimize the inflammation with a focus on skeletal muscle after exercise. On the other hand, the regulation of physical activity by the immune function saves energy consumption, and that is a system that gives higher priority to energy use for immune reaction.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (30 results) Book (1 results)

  • [Journal Article] Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I : C is maintained despite exhaustive exercise in mice2012

    • Author(s)
      Uchida M, Oyanagi E, Kremenik MJ, Sasaki J, Yano H
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 62 Issue: 1 Pages: 59-62

    • DOI

      10.1007/s12576-011-0177-4

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective action of L-carnitine on cardiac mitochondrial function and structure against fetty acid stress2011

    • Author(s)
      Oyanagi, E., Yano, H., Uchida, M., Utsumi, K., Sasaki, J.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 412 Issue: 1 Pages: 62-67

    • DOI

      10.1016/j.bbrc.2011.07.039

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise-independent wheat-induced anaphylaxis caused by ω-5 gliadin in mice2011

    • Author(s)
      Tanaka, M., Naganoa, T., Yano, H., Haruma, K., Kato, Y.
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: 156 Issue: 4 Pages: 434-442

    • DOI

      10.1159/000324469

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice2010

    • Author(s)
      Yano H, Uchida M, Nakai R, Kawanishi N, Kato Y, Kremenik MJ, Shiva D
    • Journal Title

      European Journal of Applied Physiology

      Volume: 110 Issue: 4 Pages: 797-803

    • DOI

      10.1007/s00421-010-1560-1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exhaustive exercise reduces tumor necrosis factor-alpha production in response to lipo-polysaccharide in mice2010

    • Author(s)
      Tanaka Y, Kawanishi N, Shiva D, Tsutsumi N, Uchida M, Kitamura H, Kato Y, Yano H
    • Journal Title

      NeuroImmuno-Modulation

      Volume: 17 Issue: 4 Pages: 279-286

    • DOI

      10.1159/000290044

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exhaustive exercise reduces TNF-a and IFN-a production in response to R-848 via toll-like receptor 7 in mice2010

    • Author(s)
      Yano, H., Uchida, M., Nakai, R., Kawanishi, N., Kato, Y., Kremenik, M.J., Shiva, D.
    • Journal Title

      Eur.J.Appl.Physiol.

      Volume: 110 Pages: 797-803

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exhaustive exercise reduces tumor necrosis factor-alpha production in response to lipopolysaccharide in mice2010

    • Author(s)
      Y.Tanaka, N.Kawanishi, D.Shiva, N.Tsutsumi, M.Uchida, H.Kitamura, Y.Kato, H.Yano
    • Journal Title

      NeuroImmuno Modulation 17

      Pages: 279-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] L-カルニチンのATP非依存性ミトコンドリア膜安定化作用が脂肪酸誘導性心筋障害を抑制する2011

    • Author(s)
      小柳えり、内田昌孝、矢野博己
    • Organizer
      第68回日本体力医学会中国・四国地方会
    • Place of Presentation
      島根大学教育学部(島根県)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋損傷後の炎症・修復過程におけるマクロファージ走化性と分化の関連性2011

    • Author(s)
      矢野博己
    • Organizer
      第68回日本体力医学会中国・四国地方会
    • Place of Presentation
      島根大学教育学部(島根県)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] MyotubeのCD36発現とミトコンドリア量に対するリポカインの影響2011

    • Author(s)
      内田昌孝、小柳えり、矢野博己
    • Organizer
      第68回日本体力医学会中国・四国地方会
    • Place of Presentation
      島根大学教育学部(島根県)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] オープンウィンドウ回復時の身体活動性2011

    • Author(s)
      矢野博己
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Gas6前刺激がマウスマクロファージ表現型におよぼす影響2011

    • Author(s)
      椎葉大輔、内田昌孝、矢野博己、川西範明、鈴木克彦、川上雅之
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨格筋細胞分化に伴うCD36発現低下をリポカインおよびインシュリンはPI3Kを介して抑制する2011

    • Author(s)
      内田昌孝、小柳えり、矢野博己
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] L-カルニチンは心筋ミトコンドリアの脂肪酸による膜透過性遷移とシトクロムcの漏出を抑制する2011

    • Author(s)
      小柳えり、内田昌孝、矢野博己
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Moderate exercise training do not improve LPS-induced TNF-alpha reduction after exhaustive exercise2011

    • Author(s)
      Kitamura H
    • Organizer
      The 10th International Society of Exercise and Immunology(ISEI) Symposium
    • Place of Presentation
      University of Oxford(UK)
    • Year and Date
      2011-07-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Moderate exercise training do not improve LPS-induced TNF-alpha reduction after exhaustive exercise2011

    • Author(s)
      H Kitamura, H Umetsu, K Minato, H Yano
    • Organizer
      The 10th International Society of Exercise and Immunology (ISEI) Symposium
    • Place of Presentation
      University of Oxford (UK)
    • Year and Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Curcumin attenuates oxidative stress via suppression of MCP-1 production following downhill running induced muscle damage2011

    • Author(s)
      N Kawanishi, H Yano, et al
    • Organizer
      The 10th International Society of Exercise and Immunology (ISEI) Symposium
    • Place of Presentation
      University of Oxford (UK)
    • Year and Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 医,食,運動:健康で長生きするために健康をもとめて-免疫学がおしえてくれた運動の不思議-2011

    • Author(s)
      矢野博己
    • Organizer
      おかやまバイオアクティブ研究会第39回シンポジウム(招待講演)
    • Place of Presentation
      川崎医科大学(岡山県)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 医,食,運動:健康で長生きするために健康をもとめて-免疫学がおしえてくれた運動の不思議-2011

    • Author(s)
      矢野博己
    • Organizer
      おかやまバイオアクティブ研究会第39回シンポジウム
    • Place of Presentation
      川崎医科大学(岡山県)(招待講演)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] シンポジウム「自然免疫と感染防御-Toll like receptorを介した免疫応答と運動-」2011

    • Author(s)
      矢野博己
    • Organizer
      第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
    • Year and Date
      2011-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム「自然免疫と感染防御-Toll like receptorを介した免疫応答と運動-」2011

    • Author(s)
      矢野博己
    • Organizer
      第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会 合同大会
    • Place of Presentation
      東日本震災のため誌上発表
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] オープンウィンドウ学説の解明-TNF-αを指標として-2010

    • Author(s)
      矢野博己
    • Organizer
      第66回日本体力医学会中国・四国地方会
    • Place of Presentation
      徳島大学(徳島県)
    • Year and Date
      2010-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 疲労困懲運動による免疫抑制は炎症性サイトカインとともに抗炎症性サイトカインでも生じる2010

    • Author(s)
      小柳えり, 内田昌孝, 矢野博己
    • Organizer
      第66回日本体力医学会中国・四国地方会
    • Place of Presentation
      徳島大学、徳島
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] オープンウィンドウ学説の解明-TNF-αを指標として-2010

    • Author(s)
      矢野博己
    • Organizer
      第66回日本体力医学会中国・四国地方会
    • Place of Presentation
      徳島大学、徳島
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] LPS誘導性TNF-α産生は疲労困憊運動によって抑制される2010

    • Author(s)
      矢野博己
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(千葉県)
    • Year and Date
      2010-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] LPS誘導性TNF-a産生は疲労困癒運動によって抑制される2010

    • Author(s)
      矢野博己, 内田昌孝, 小柳えり
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学、千葉
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 教育講演「運動免疫学から個体差を考える」2010

    • Author(s)
      矢野博己
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(千葉県)
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム「細菌およびウイルスモデルに対する免疫応答と運動」2010

    • Author(s)
      矢野博己
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(千葉県)
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 教育講演「運動免疫学から個体差を考える」2010

    • Author(s)
      矢野博己
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(招待講演)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム「細菌およびウイルスモデルに対する免疫応答と運動」2010

    • Author(s)
      矢野博己
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] The response of voluntary physical activity to R-848 via TLR7 in mice2010

    • Author(s)
      Yano H
    • Organizer
      57th Annual Meeting of The American College of Sports Medicine
    • Place of Presentation
      Baltimore(USA)
    • Year and Date
      2010-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] The response of voluntary physical activity to R-848 via TLR7 in mice2010

    • Author(s)
      H.Yano, J.A.Woods
    • Organizer
      57th Annual Meeting of The American College of Sports Medicine
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] TLR3を介した免疫応答に及ぼす急性運動の影響2010

    • Author(s)
      内田昌孝, 小柳えり, 矢野博己
    • Organizer
      第65回日本体力医学会中国・四国地方会
    • Place of Presentation
      川崎医療福祉大学、岡山
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Exhaustive exercise reduces TNF-alpha and IFN-gamma production in response to R-848 via toll-like receptor 7 in mice2009

    • Author(s)
      Yano H
    • Organizer
      9th Symposium of the International Society of Exercise and immunology
    • Place of Presentation
      Tubingen(Germany)
    • Year and Date
      2009-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Exhaustive exercise reduces TNF-alpha and IFN-gamma production in response to R-848 via toll-like receptor 7 in mice2009

    • Author(s)
      H.Yano, M.Uchida, R.Nakai, N.Kawanishi, Y.Kato, M.J.Kremenik, D.Shiva
    • Organizer
      9th Symposium of the International Society of Exercise and immunology
    • Place of Presentation
      ドイツ チュービンゲン
    • Year and Date
      2009-09-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] The response of voluntary physical activity via TLR3 and TLR7/8 in mice2009

    • Author(s)
      Yano H
    • Organizer
      56th Annual Meeting of The American College of Sports Medicine
    • Place of Presentation
      Seattle(USA)
    • Year and Date
      2009-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] The response of voluntary physical activity via TLR3 and TLR7/8 in mice2009

    • Author(s)
      H.Yano, T.Matsumoto, C.Yoshida, M.Uchida, V.Tanaka, N.Kawanishi, D.Shiva, J.A.Woods
    • Organizer
      56th Annual Meeting of The American College of Sports Medicine
    • Place of Presentation
      米国 シアトル
    • Year and Date
      2009-05-27
    • Related Report
      2009 Annual Research Report
  • [Book] 運動生理学のニューエビデンス2010

    • Author(s)
      宮村実晴(編)矢野博己, 他
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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