Applied research on the relationship between bacterial/viral infections and reduction of exercise performance
| Project/Area Number |
21500700
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
YANO Hiromi 川崎医療福祉大学, 医療技術学部, 准教授 (20248272)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 病原体関連分子 / TLRs / 疲労困憊運動 / 自発運動 / マウス / マクロファージ / サイトカイン / 腸管上皮細胞 / フラジェリン / poly I:C / R-848 |
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| Research Abstract |
We have shown that protection against bacterial and/or viral infections is inhibited by an intense exercise, and physical activity is inhibited by the immune defense function after infection. Immunosuppression due to the intense exercise is a reasonable reaction defense to minimize the inflammation with a focus on skeletal muscle after exercise. On the other hand, the regulation of physical activity by the immune function saves energy consumption, and that is a system that gives higher priority to energy use for immune reaction.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Exhaustive exercise reduces TNF-a and IFN-a production in response to R-848 via toll-like receptor 7 in mice2010
Author(s)
Yano, H., Uchida, M., Nakai, R., Kawanishi, N., Kato, Y., Kremenik, M.J., Shiva, D.
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Journal Title
Eur.J.Appl.Physiol.
Volume: 110
Pages: 797-803
Related Report
Peer Reviewed
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