Development of a diabetes risk profile using a urinary biomarker and its application in the assessment of nutrient status and exercise levels.
| Project/Area Number |
21500701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
HASHIDA Seiichi 徳島文理大学, 健康科学研究所, 教授 (10156268)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIDO Kazumi 徳島文理大学, 健康科学研究所, 教授 (40212906)
UMEHARA Asako 徳島文理大学, 人間生活学部, 助手 (60441599)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 糖尿病 / 早期診断 / 生理活性物質 / バイオマーカー / リスクプロファイリング / 機能性食品 / 栄養指導 / 運動指導 / 尿 / 免疫測定法 / アセスメント / 運動・栄養指導 / 早期腎障害 / リスク評価 |
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| Research Abstract |
The early detection of individuals with pre-diabetes and the subsequent modification of lifestyle is an important strategy in the prevention of diabetes. We have developed a new technique of detecting pre-diabetes using urine and a dry filter paper blood sample. We applied this novel technique to the assessment of nutrient status and exercise levels.
Urinary soluble insulin receptor, resistin, and insulin were significantly increased in diabetic patients. Thus, it is possible to assess diabetes risk using a combination of these urinary biomarkers. In addition, we showed that these biomarkers were improved by positive lifestyle changes, including an increase in exercise and consumption of dietary fiber.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading2009
Author(s)
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T.
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Journal Title
MolCell Biol
Volume: 29(17)
Pages: 4798-4811
Related Report
Peer Reviewed
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