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Neuroscientific approach for evaluation of food texture

Research Project

Project/Area Number 21500765
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionTokyo Health Care University (2011)
Kanagawa Dental College (2009-2010)

Principal Investigator

KOJO Akiko  東京医療保健大学, 医療保健学部, 准教授 (30412927)

Co-Investigator(Kenkyū-buntansha) YANAGISAWA Yukie  和洋女子大学, 生活科学系, 教授 (60191160)
YAMAMOTO Toshiharu  神奈川歯科大学, 歯学部, 准教授 (50111901)
TACHIBANA Atsumichi  神奈川歯科大学, 歯学部, 非常勤講師 (80409995)
ONOZUKA Minoru  神奈川歯科大学, 歯学部, 教授 (90084780)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経科学 / 咀嚼 / 食品 / テクスチャー / 賦活
Research Abstract

The present project aimed to evaluate food texture by means of neuroscientific techniques. The influence of food texture on the mouse brain was surveyed. Powdered food, in which mice can take using tongue but not teeth, resulted in the increase of hippocampal and diencephalon BDNF levels. However, this increase was not detected under hard(control) and soft food intake conditions. These results suggest that stimulation of the oral cavity through teeth is important to sustain ordinal brain functions regardless of hard or soft food texture. Increase of BDNF may be one of brain reactions against the stress caused by non-utilization of teeth.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (7 results)

  • [Journal Article] Chewing ameliorates stress-induced suppression of spatial memory by increasing glucocorticoid receptor expression in the hippocampus2012

    • Author(s)
      Miyake S, Yoshikawa G, Yamada K, Sasaguri K, Yamamoto T, Onozuka M, Sato S.
    • Journal Title

      Brain Research

      Volume: 1446 Pages: 34-39

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 給食施設における摂食機能の低下を考慮した食種の標準化を目的とした食形態および適応の現状分析2011

    • Author(s)
      小城明子, 竹内由里, 河野みち代, 高杉(森)一恵, 浅野恭代, 大石明子, 佐藤礼子, 下田妙子, 柳沢幸江
    • Journal Title

      日本摂食・嚥下リハビリテーション学会雑誌

      Volume: 15 Pages: 14-24

    • NAID

      130007864152

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of chemokine CXCL14 in rat hypothalamic neurons2011

    • Author(s)
      Yamamoto T, Yamashita A, Yamada K, Hata R.
    • Journal Title

      Neurosecience Letters

      Volume: 487 Pages: 335-340

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct projections from the central amygdaloid nucleus to the mesencephalic trigeminal nucleus in rats.2011

    • Author(s)
      Shirasu M, Takahashi T, Yamamoto T, Itoh K, Sato S, Nakamura H.
    • Journal Title

      Brain Research

      Volume: 1400 Pages: 19-30

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct projections from the central amygdaloid nucleus to the mesencephalic trigeminal nucleus in rats2011

    • Author(s)
      T.Yamamoto (M.Shirasu)
    • Journal Title

      Brain Research

      Volume: 1400 Pages: 19-30

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食種の物性特徴を示す主観的表現の客観的数値化2010

    • Author(s)
      小城明子, 森一恵, 竹内由里, 河野みち代, 浅野恭代, 大石明子, 佐藤礼子, 下田妙子, 柳沢幸江
    • Journal Title

      日本摂食・嚥下リハビリテーション学会雑誌

      Volume: 14 Pages: 33-41

    • NAID

      130007865583

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occlusal Disharmony in Mice Transiently Activates Microglia in Hippocampal CA1 Region but Not in Dentate Gyrus2010

    • Author(s)
      Kojo A, Yamada K, Kubo KY, Yamashita A, Yamamoto T.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 221 Pages: 237-243

    • NAID

      10027085153

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypothermic and normothermic ischemia-reperfusion activate microglia differently in hippocampal formation2010

    • Author(s)
      Yamashita A, Kunimatsu T, Yamada K, Kojo A, Yamamoto T, Sato S, Onozuka M.
    • Journal Title

      Archives of Histology and Cytology

      Volume: 73 Pages: 73-80

    • NAID

      10028160100

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 不正咬合者における食べにくい食品とその物性2010

    • Author(s)
      阿部友里子、宮谷真理子、茂木悦子、野村真弓、河野みち代、柳沢幸江、石井武展、末石研二
    • Journal Title

      歯科学報

      Volume: 110 Pages: 767-774

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 不正咬合者における食べにくい食品の有無と咬合力評価2010

    • Author(s)
      宮谷真理子、阿部友里子、茂木悦子、野村真弓、河野みち代、柳沢幸江、石井武展、末石研二
    • Journal Title

      歯科学報

      Volume: 110 Pages: 775-783

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食種の物性特徴を示す主観的表現の客観的数値化2010

    • Author(s)
      小城明子, 柳澤幸江
    • Journal Title

      日本摂食・嚥下リハビリテーション学会雑誌

      Volume: 14巻 Pages: 33-41

    • NAID

      130007865583

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occlusal Disharmony in Mice Transiently Activates Microglia in Hippocampal CA1 Region but Not in Dentate Gyrus2010

    • Author(s)
      小城明子, 山本利春
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: Vol.221 Pages: 237-243

    • NAID

      10027085153

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothermic and normothermic ischemia-reperfusion activate microglia differently in the hippocampal formation2010

    • Author(s)
      小城明子, 山本利春
    • Journal Title

      Archives of Histology and Cytology

      Volume: Vol.73(印刷中)

    • NAID

      10028160100

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不正咬合者における食べにくい食品とその物性2010

    • Author(s)
      柳澤幸江
    • Journal Title

      歯科学報

      Volume: 110巻 Pages: 767-774

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不正咬合者における食べにくい食品の有無と咬合力測定2010

    • Author(s)
      柳澤幸江
    • Journal Title

      歯科学報

      Volume: 110巻 Pages: 775-783

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drebrin(developmentally regulated brain protein) is associated with axo-somatic synapses and neuronal gap junctions in rat mesencephalic trigeminal nucleus2009

    • Author(s)
      Park H, Yamada K, Kojo A, Sato S, Onozuka M, Yamamoto T.
    • Journal Title

      Neuroscience Letters

      Volume: 461 Pages: 95-99

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drebrin (developmentally regulated brain protein) is associated with axo-somatic synapses and neuronal gap junctions in rat mesencephalic trigeminal nucleus2009

    • Author(s)
      Hansung Park
    • Journal Title

      Neuroscience Letters 461

      Pages: 95-99

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 摂食機能に適合する食形態選択ツールの開発を目的とした,嚥下内視鏡検査及び質問表による摂食機能評価分析2011

    • Author(s)
      柳沢幸江, 小城明子, 竹内由里, 田中賦彦, 河野みち代, 高杉一恵, 大石明子, 浅野恭代, 佐藤礼子, 細田明美, 下田妙子
    • Organizer
      日本栄養改善学会
    • Place of Presentation
      広島
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 居宅介護高齢者のケア・マネジメントにおける食事に関する課題の検討2011

    • Author(s)
      宇田川孝子、柳澤幸江
    • Organizer
      日本栄養改善学会
    • Place of Presentation
      広島
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 居摂食機能に適合する食形態選択ツールの開発を目的とした, 嘸下内視鏡検査及び質問表による摂食機能評価分析2011

    • Author(s)
      小城明子(柳澤幸江)
    • Organizer
      日本栄養改善学会
    • Place of Presentation
      広島
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bite-raised condition transiently activates microglia in the mouse hippocampal CA1 but not in the dentate gyrus2009

    • Author(s)
      Akiko Kojo, Kentaro Yamada, Anzu Yamashita, Toshiharu Yamamoto, Minoru Onozuka
    • Organizer
      32nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Microglial reaction against transient global ischemia is higher in the hypothermia than in the normothermia2009

    • Author(s)
      Anzu Yamashita, Teruhito Kunimatsu, Kentaro Yamada, Akiko Kojo, Sadao Sato, Minoru Onozuka
    • Organizer
      32nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Bite-raised condition transiently activates microglia in the mouse hippocampal CA1 but not in the dentate gyrus2009

    • Author(s)
      小城明子
    • Organizer
      32^<nd> Annual Meeting of the Japan Neuroscience Society(第32回日本神経科学大会)
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microglial reaction against transient global ischemia is higher in the hypothermia than in the normothermia2009

    • Author(s)
      山下杏
    • Organizer
      32^<nd> Annual Meeting of the Japan Neuroscience Society(第32回日本神経科学大会)
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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