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Health promotional effects of the combination of supplementation and exercise in old mice having various genetic backgrounds

Research Project

Project/Area Number 21500777
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionShinshu University

Principal Investigator

SAWASHITA Jinko  信州大学, 医学系研究科, 助教 (40359732)

Co-Investigator(Renkei-kenkyūsha) HIGUCHI Keiichi  信州大学, 医学系研究科, 教授 (20173156)
MORI Masayuki  信州大学, 医学系研究科, 准教授 (60273190)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords健康と食生活 / 抗加齢 / 栄養素調節 / 運動 / 疾患モデル動物 / 栄養 / モデル動物
Research Abstract

This study is a basic medical research that analyzed health promotional effects of the short-term combination of nutrient supply and high-intensity interval walking exercise in old mice having various genetic backgrounds. We found that high-levels of fasting blood glucose in mice were improved after the intervention of supplementation with flavonoids and exercise for only three weeks, and that the combination of supplementation and exercise had a good effect for obesity compared with exercise alone. We have to investigate a dose of nutrient, an interventional period, an optimal route, and the molecular mechanism, but we believe that these findings and strategies are useful to help the health promotion for the elderly person.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (8 results)

  • [Journal Article] The reduced form of Coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice.2010

    • Author(s)
      Constance Schmelzer, et al.
    • Journal Title

      IUBMB Life

      Volume: 62 Pages: 812-818

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of mild calorie restriction and high-intensity interval walking in middle-aged and older overweight Japanese2009

    • Author(s)
      Jinko Sawashita, et al.
    • Journal Title

      Exp Gerontol 44

      Pages: 666-675

    • NAID

      120007110404

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a PPAR-α gene expression signature in SAMP1 mice2009

    • Author(s)
      Constance Schmelzer, et al.
    • Journal Title

      Mol Nutr Food Res (Epub.)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 還元型コエンザイムQ10は老化促進モデルマウスSAMP1の酸化ストレスを軽減し、加齢性難聴を遅延する2011

    • Author(s)
      田耕、澤下仁子, ほか
    • Organizer
      第6回臨床ストレス応答学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス老化アミロイドタンパク質(apolipoprotein A-II)トランスジェニックマウスは促進老化を示す?2011

    • Author(s)
      澤下仁子、王耀勇、田耕、羅宏敏、陳磊、森政之、樋口京一
    • Organizer
      第27回日本老年学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 還元型コエンザイムQ10は老化促進モデルマウスSAMP1の促進老化と加齢性難聴の進行を遅延する2011

    • Author(s)
      澤下仁子、田耕, ほか
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 還元型コエンザイムQ10は老化促進モデルマウスSAMP1の促進老化を遅延する2011

    • Author(s)
      澤下仁子、田耕、久保博司、Constance Schmelzer、橋本繁成、森政之、細江和典、北野光昭、Frank Doring、宇佐美真一、樋口京一
    • Organizer
      第8回日本コエンザイムQ協会研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-01-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 老化促進モデルマウス(SAMP 1)を用いた還元型Q10の抗老化作用の解明2010

    • Author(s)
      田耕、澤下仁子, ほか
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] SAMにおける食事脂肪と促進老化について2009

    • Author(s)
      梅澤真樹子、樋口京一、森政之、松下隆寿、細川昌則
    • Organizer
      第24回老化促進モデルマウス(SAM)研究協議会
    • Place of Presentation
      松本
    • Year and Date
      2009-07-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 還元型コエンザイムQ10の継続摂取による老化促進モデルマウス(SAMP1)の促進老化遅延効果2009

    • Author(s)
      澤下仁子、久保博司、厳景民、張.茹、森政之、Constance Schmelzer、竹田俊男、Frank Doring、樋口京一
    • Organizer
      第9回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 還元型コエンザイムQ10の継続摂取による老化促進モデルマウス(SAMP1)の促進老化遅延効果2009

    • Author(s)
      澤下仁子, ほか
    • Organizer
      第9回日本抗加齢医学会 総会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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