A comprehensive search for antiangiogenic food factors and molecular biological analysis of their mode of inhibition
| Project/Area Number |
21500782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
OHTA Toshiro 静岡県立大学, 食品栄養環境科学研究院, 助教 (40285193)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAZAWA Shigenori 静岡県立大学, 食品栄養科学部, 教授 (10295561)
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| Co-Investigator(Renkei-kenkyūsha) |
KUNIMASA Kazuhiro がん研究会, がん化学療法センター, 特任研究員 (50534020)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 健康と食生活 / 癌予防 / 血管新生 / 食品成分 / 分子細胞生物学 / アポトーシス / シグナル伝達 |
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| Research Abstract |
In recent years, it has been shown that for solid tumors to grow continuously they need constant supply of nutrients and oxygen from the blood and they induce angiogenesis, a local expansion of blood vessel network, to achieve that go al. It has also been shown that inhibition of such tumor angiogenesis is a new and very effective strategy for cancer treatment. As an application of this new cancer-treating strategy, a basic research toward developing antiangiogenic foods that can be used to prevent cancer was conducted. As a result, various plant extracts and their active ingredients were shown to possess antiangiogenic activities and their modes of inhibition were compared.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis.2011
Author(s)
Kunimasa K, Ohta T, Tani H, Kato E, Eguchi R, Kaji K, Ikeda K, Mori H, Mori M, Tatefuji T, Yamori Y
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Journal Title
Mol Nutr Food Res
Volume: 55(11)
Issue: 11
Pages: 1730-4
DOI
Related Report
Peer Reviewed
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