A study in the field of Food Science and Nutrition seeking for capability of edible yomogi to prevent atherosclerosis

• Project/Area Number: 21500784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: University of Hyogo
• Principal Investigator: HIRAMATSU Naoko 兵庫県立大学, 環境人間学部, 准教授 (30099585)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 健康と食生活 / ヨモギ / CaCo-2 cell / HepG2 cell / カイロミクロン / LDL / ApoB48 / ApoB100 / 動脈硬化 / ヒトLDL抗酸化 / LDLコレステロール / ヨモギ熱水抽出成分 / HepG2細胞 / CaCo-2細胞

Research Abstract

Yomogi water extracts extended the lag phase of conjugated diene formation in human LDL oxidation. Yomogi water extracts dose-dependently inhibited hexanoyl lysine and TBARS formations, and degradation of ApoB100 in human LDL oxidation. These results indicate yomogi has a strong anti-oxidative activity in each phase from the beginning to the end of LDL oxidation. Yomogi water extracts inhibited secretion of ApoB48(chylomicron) from human intestinal CaCo-2 cells, and inhibited synthesis of ApoB100(LDL-cholesterol) in human HepG2 cells. Collectively, the results imply that daily consumption of yomogi may have an effect to slow down the development of human atherosclerosis.

Research Products

• [Journal Article] グローバルコミュニケーションを通して学ぶ栄養学-バーチャルフィールドワークからジョイントクラスプロジェクトまで- (2012)
  • Author(s): 平松直子
  • Journal Title: 兵庫県立大学環境人間学部研究報告 Volume: 14 Pages: 51-60
  • NAID: 110008919997
  • Peer Reviewed
• [Journal Article] A Study on Capability of Edible Yomogi to Prevent Atherosclerosis : The in vitro Inhibitory Effect of Yomogi Caffeic Acid on Human LDL Oxidation (2011)
  • Author(s): Naoko Hiramatsu
  • Journal Title: Proceedings of the 19th International Joint Seminar Between the Dong-A University & the University of Hyogo Volume: 19 Pages: 25-25
• [Journal Article] Role of n-3 series polyunsaturated fatty acids in cardiovascular disease prevention (2011)
  • Author(s): Andy H Lee, Naoko Hiramatsu
  • Journal Title: Nutrition and Dietary Supplements Volume: 3 Pages: 93-100
  • Peer Reviewed
• [Journal Article] A Study on Capability of Edible Yomogi to Prevent Atherosclerosis : The in vitro Inhibitory Effect of Yomogi Caffeic Acid on Human LDL Oxidation (2011)
  • Author(s): Naoko Hiramatsu
  • Journal Title: Proceeding of the 19^<th> International Joint Seminar Between the Dong-A University & the University of Hyogo Volume: 19 Pages: 25-25
• [Journal Article] Dietary intake of six minerals in relation to the risk of chronic obstructive pulmonary disease. (2010)
  • Author(s): Hirayama F, Lee AH Oura A, Mori M, Hiramatsu N, Taniguchi H.
  • Journal Title: Asia Pacific Journal of Clinical Nutrition. Volume: 19(4) Pages: 572-7
  • Peer Reviewed
• [Journal Article] Dietary nutrients in relation to chronic obstructive pulmonary disease : Emerging epidemiological evidence. (2010)
  • Author(s): Hirayama F, Lee AH, Hiramatsu N.
  • Journal Title: Current Respiratory Medicine Reviews Volume: 6(2) Pages: 124-132
  • Peer Reviewed
• [Journal Article] Dietary intake of isoflavones and polyunsaturated fatty acids associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease : Possible protective effect of traditional Javanese diet (2010)
  • Author(s): Hirayama F, Lee AH, Binns CW Hiramatsu N, Mori M, Nishimura K.
  • Journal Title: Molecular Nutrition & Food Research 54 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Studies on Functional Components of Japanese Traditional Herb Yomogi for Prevention of Lifestyle-related Diseases-Inhibitory Effect of Yomogi on Human LDL Oxidation in vitro (2009)
  • Author(s): Naoko Hiramatsu
  • Journal Title: Proceedings of the 17th international joint seminar between university of Hyogo and Dong-A university Volume: 17 Pages: 45-49
• [Journal Article] Japanese Seasoning "Umami" (2009)
  • Author(s): Naoko Hiramatsu
  • Journal Title: The 18th International Joint Seminar between the Dong-A University & the University of Hyogo(セミナー論文集) Volume: 18 Pages: 6-10
  • Peer Reviewed
• [Journal Article] Studies on Functional Components of Japanese Traditional Herb Yomogi for Prevention of Lifestyle-related Diseases -Inhibitory Effect of Yomogi on Human LDL Oxidation in vitro- (2009)
  • Author(s): Naoko Hiramatsu
  • Journal Title: The 17th International Joint Seminar between the Dong-A University & the University of Hyogo(セミナー論文集) 17 Pages: 45-49
• [Presentation] A Study on Capability of Edible Yomogi to Prevent AtheroscIerosis : The in vitro Inhibitory Effect of Yomogi Caffeic Acid on Human LDL Oxidation (2011)
  • Author(s): 平松直子
  • Organizer: The 19th International Joint Seminar Between the Dong-A University & the University of Hyogo
  • Place of Presentation: Dong-A University (Busan)(招待講演)
  • Year and Date: 2011-10-14
• [Presentation] 動脈硬化予防食材としてのヨモギの可能性を探る研究:CaCo-2及びHepG2細胞培養系におけるApoB48及びApoB100合成・分泌への影響 (2011)
  • Author(s): 平松直子、阿尾達紀、山中誠也、須原麻由、森下愛
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京)
  • Year and Date: 2011-05-14
• [Presentation] A Study on Capability of Edible Yomogi to Prevent Atherosclerosis : The in vitro Inhibitory Effect of Yomogi Caffeic Acid on Human LDL Oxidation (2011)
  • Author(s): Naoko Hiramatsu
  • Organizer: The 19th international joint seminar between university of Hyogo and Dong-A university
  • Place of Presentation: Dong-A university, Pusan, Korea
• [Presentation] 動脈硬化予防食材としてのヨモギの可能性を探る研究: CaCo-2およびHepG2細胞培養系の各ApoB48およびApoB100の合成・分泌を抑制するか? (2011)
  • Author(s): 平松直子・須原麻由・森下愛
  • Organizer: 日本栄養食糧学会全国大会
  • Place of Presentation: 東京,お茶の水女子大学
• [Presentation] ヨモギの動脈硬化予防食材としての可能性を探る研究 (2010)
  • Author(s): 平松直子、伊藤美紀子、加藤陽二、阿尾達紀、山中誠也
  • Organizer: 日本家政学会近畿支部総会
  • Place of Presentation: 兵庫県立大環境人間学部
  • Year and Date: 2010-10-23
• [Presentation] 伝統的な食用野草のアク抜き処理が抗酸化作用に及ぼす影響と成分の推定 (2010)
  • Author(s): 河上智紀、加藤陽二、平松直子
  • Organizer: 日本家政学会近畿支部総会
  • Place of Presentation: 兵庫県立大環境人間学部
  • Year and Date: 2010-10-23
• [Presentation] Japanese Seasoning, Umami (2010)
  • Author(s): Naoko Hiramatsu
  • Organizer: A lecture in a class for junior students of dietitian course, at Department of Food Science and Human Nutrition, ISU
  • Place of Presentation: Ames, Iowa, USA
  • Year and Date: 2010-09-20
• [Presentation] Studies on Functional Components of the Japanese Traditional Herb Yomogi (2010)
  • Author(s): Naoko Hiramatsu
  • Organizer: Seminar for graduate students and staffs, Department of Food Science and Human Nutrition, ISU
  • Place of Presentation: Ames, Iowa, USA
  • Year and Date: 2010-09-20
• [Presentation] The Current Dietetics Profession in Japan (2010)
  • Author(s): Naoko Hiramatsu
  • Organizer: A lecture in the guidance class for junior grade students of dietitian course at Department of Food Science and Human Nutrition, Iowa State University (ISU)
  • Place of Presentation: Ames, Iowa, USA
  • Year and Date: 2010-09-17
• [Presentation] 日本産ヨモギ茶飲用が血管内皮機能(動脈硬化抑制指標)に及ぼす影響 (2010)
  • Author(s): 平松直子、山本大志、永井成美、加藤陽二
  • Organizer: 日本栄養食糧学会全国大会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-23
• [Presentation] 伝統的な食用野草のアク抜き処理が抗酸化活性に与える影響と成分の推定 (2010)
  • Author(s): 河上智紀, 加藤陽二, 平松直子
  • Organizer: 日本家政学会近畿支部大会
  • Place of Presentation: 姫路,兵庫県立大学
• [Presentation] ヨモギの動脈硬化予防食材としての可能性を探る研究 (2010)
  • Author(s): 平松直子, 伊藤美紀子, 加藤陽二, 阿尾達紀, 山中誠也
  • Organizer: 日本家政学会近畿支部総会
  • Place of Presentation: 姫路、兵庫県立大学
• [Presentation] 日本産ヨモギ茶飲用が血管内皮機能(動脈硬化抑制指標)に及ぼす影響 (2010)
  • Author(s): 平松直子, 山本大志, 永井成美, 加藤陽二
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: 徳島,アスティとくしま
• [Presentation] Studies on Functional Components of Japanese Traditional Herb Yomogi for Prevention of Lifestyle-related Diseases. Inhibitory Effect of Yomogi on Human LDL Oxidation in vitro (2009)
  • Author(s): Naoko Hiramatsu
  • Organizer: The 17th international joint seminar between university of Hyogo and Dong-A university
  • Place of Presentation: Dong-A university, Pusan, Korea
• [Presentation] Estimation of the in vitro Inhibitory Effect of Yomogi Caffeic Acid on Human LDL Oxidation Compared to Vitamins C and E (2009)
  • Author(s): Naoko Hiramatsu, Yukika Tauchi, Yoji Kato, Toshiro.Watanabe
  • Organizer: ICN 2009(The 19^<th> International Congress of Nutrition)
  • Place of Presentation: Bangkok International Trade & Exhibition Centre
• [Presentation] Dietary Survey of Intakes of n-6 and n-3 Poly Unsaturated Fatty Acids(PUFAS)and Chronic Diseases in Adults in Kamikawa-Cho, Hyogo, Japan (2009)
  • Author(s): Naoko Hiramatsu, Mayuko Nishie
  • Organizer: ICN 2009(The 19^<th> International Congress of Nutrition)
  • Place of Presentation: Bangkok International Trade & Exhibition Centre
• [Book] Chapter 11.Vitamin A Intake in Relation to Lung Function, Breathlessness and the Risk of Chronic Obstructive Pulmonary Disease.in "Vitamin A : Nutrition, Side Effects, and Supplements" edited by Lucas P.Scott (2011)
  • Author(s): Hirayama F, Lee AH, Hiramatsu N.
  • Publisher: Nova Science Publishers, Inc.
• [Remarks]
  • URL: http://www.u-hyogo.ac.jp/shse/hiramats/