| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Yomogi water extracts extended the lag phase of conjugated diene formation in human LDL oxidation. Yomogi water extracts dose-dependently inhibited hexanoyl lysine and TBARS formations, and degradation of ApoB100 in human LDL oxidation. These results indicate yomogi has a strong anti-oxidative activity in each phase from the beginning to the end of LDL oxidation. Yomogi water extracts inhibited secretion of ApoB48(chylomicron) from human intestinal CaCo-2 cells, and inhibited synthesis of ApoB100(LDL-cholesterol) in human HepG2 cells. Collectively, the results imply that daily consumption of yomogi may have an effect to slow down the development of human atherosclerosis.
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