A Study of Suppresive Effect on Cardiopathy by Inflammation Resolution Effect of Resolvin D1, Metabolite of DocosahexaenoicAcid
| Project/Area Number |
21500788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kagawa Prefectural College of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KABUTO Hideaki 香川県立保健医療大学, 教養部, 教授 (00321266)
HIRAKAWA Eiichiro 香川県立保健医療大学, 保健医療学部, 教授 (60238342)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 機能性脂質 / 心疾患 / 炎症 / ドコサヘキサエン酸(DHA) / レゾルビンD1 / n3系不飽和脂肪酸 / 心不全 / エイコサペンタエン酸(EPA) / レゾルビン / イオンチャネル / 洞房結節 |
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| Research Abstract |
The rats induced inflammatory right-sided congestive heart failure (CHF) by monocrotaline, were intraperitonealy injected 0.1μg/day or 1μg/day resolvin D1 (RvD1) for 8 days. The rats were dissected after 3 weeks. The morbidities of lung, such as thickness of wall of pulmonary artery and atelectasis, were suppressed in RvD1 injected groups. The survival ratios were, 43.3% for CHF, 63.9%for 0.1μg/day and 72.3% for 1μg/day RvD1 injection. The morbidities of heart in CHF examined by electrocardiograph, pathological observation and marker of cardiopathy, were not suppressed by RvD1 injection.
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Report
(4 results)
Research Products
(13 results)
