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A Study of Suppresive Effect on Cardiopathy by Inflammation Resolution Effect of Resolvin D1, Metabolite of DocosahexaenoicAcid

Research Project

Project/Area Number 21500788
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKagawa Prefectural College of Health Sciences

Principal Investigator

YAMANUSHI Tomoko  香川県立保健医療大学, 教養部, 准教授 (40382395)

Co-Investigator(Kenkyū-buntansha) KABUTO Hideaki  香川県立保健医療大学, 教養部, 教授 (00321266)
HIRAKAWA Eiichiro  香川県立保健医療大学, 保健医療学部, 教授 (60238342)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords機能性脂質 / 心疾患 / 炎症 / ドコサヘキサエン酸(DHA) / レゾルビンD1 / n3系不飽和脂肪酸 / 心不全 / エイコサペンタエン酸(EPA) / レゾルビン / イオンチャネル / 洞房結節
Research Abstract

The rats induced inflammatory right-sided congestive heart failure (CHF) by monocrotaline, were intraperitonealy injected 0.1μg/day or 1μg/day resolvin D1 (RvD1) for 8 days. The rats were dissected after 3 weeks. The morbidities of lung, such as thickness of wall of pulmonary artery and atelectasis, were suppressed in RvD1 injected groups. The survival ratios were, 43.3% for CHF, 63.9%for 0.1μg/day and 72.3% for 1μg/day RvD1 injection. The morbidities of heart in CHF examined by electrocardiograph, pathological observation and marker of cardiopathy, were not suppressed by RvD1 injection.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2012 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results)

  • [Journal Article] Effects of Docosahexaenoic Acid in an Experimental Rat Model of Nonalcoholic Steatohepatitis2010

    • Author(s)
      Takayama F, Nakamoto K, Totani N, Yamanushi T, Kabuto H, Kaneyuki T, Mankura M
    • Journal Title

      Journal of Oleo Science

      Volume: 59(8) Pages: 407-414

    • NAID

      130000301374

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DHA 製品の開発と機能性評価2010

    • Author(s)
      万倉三正,西岡功志,加太英明,山主智子,戸谷永生,中本賀寿夫,金行孝雄,高山房子
    • Journal Title

      ジャパンフードサイエンス

      Volume: 49(1) Pages: 45-52

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DHA製品の開発と機能性評価2010

    • Author(s)
      万倉三正, 西岡功志, 加太英明, 山主智子, 戸谷永生, 中本賀寿夫, 金行孝雄, 高山房子
    • Journal Title

      ジャパンフードサイエンス

      Volume: 49(1) Pages: 45-52

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 「高純度ドコサヘキサエン酸投与によるラット肺高血圧症の予防」予防2012

    • Author(s)
      山主 智子、加太 英明、平川 栄一郎、ジャンジュア ナジマ、高山 房子、万倉三正
    • Place of Presentation
      仙台市東北大学
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 高純度ドコサヘキサエン酸投与によるラット肺高血圧症の予防2012

    • Author(s)
      山主智子
    • Organizer
      第66回日本栄養食糧学会
    • Place of Presentation
      東北大学(仙台市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ドコサヘキサエン酸代謝物レゾルビンD1摂取によるラット炎症性右鬱血心不全の抑制効果」2010

    • Author(s)
      山主智子、加太英明、平川栄一郎
    • Organizer
      日本脂質栄養学会第19回大会
    • Place of Presentation
      犬山市名鉄犬山ホテル
    • Year and Date
      2010-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] ドコサヘキサエン酸代謝物レゾルビンD1摂取によるラット炎症性右鬱血心不全の抑制効果2010

    • Author(s)
      山主智子、加太英明、平川栄一郎
    • Organizer
      日本脂質栄養学会第19回大会
    • Place of Presentation
      犬山市、名鉄犬山ホテル
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高純度エイコサペンタエン酸及びドコサヘキサエン酸経口投与によるラット心臓機能の変化2010

    • Author(s)
      山主智子,加太英明,Janjua Najma, 高山房子,万倉三正
    • Organizer
      第64回日本栄養食糧学会大会
    • Place of Presentation
      徳島市アスティ徳島
    • Year and Date
      2010-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 高純度エイコサペンタエン酸及びドコサヘキサエン酸経口投与によるラット心臓機能の変化2010

    • Author(s)
      山主智子, 加太英明, Janjua Najma, 高山房子, 万倉三正
    • Organizer
      第64回日本栄養食糧学会大会
    • Place of Presentation
      徳島市、アスティ徳島
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Changes in ion channel expression in the rat sinoatrial node in right-sided congestive heart failure2010

    • Author(s)
      Tomoko T. Yamanushi, Joseph Yanni, Halina Dobrzynski, Hideaki Kabuto, Mark R. Boyett
    • Organizer
      XXth World Congress of the International Society for Heart Research 2010
    • Place of Presentation
      京都市、国立京都国際会館
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] n3系 不飽和脂肪酸DHA及びEPA経口投与によるラット心臓内脂肪酸組成の変化2009

    • Author(s)
      山主智子,加太英明,万倉三正
    • Organizer
      第18回日本脂質栄養学会大会
    • Place of Presentation
      東京都港区コクヨホール
    • Year and Date
      2009-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] n3系不飽和脂肪酸DHA及びEPA経口投与によるラット心臓内脂肪酸組成の変化2009

    • Author(s)
      山主智子, 加太英明, 万倉三正
    • Organizer
      第18回日本脂質栄養学会大会
    • Place of Presentation
      東京都港区コクヨホール
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Remodeling of the extracellular matrix in the rat sinoatrial node in congestive heart failure2009

    • Author(s)
      J. Yanni, T. Yamanushi, H. Dobrzynski and M.R. Boyett
    • Organizer
      The Physiological Society meeting
    • Place of Presentation
      Dublin, UK
    • Related Report
      2012 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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