| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
In vitro screening was performed for trace elements and rare metals that influence the enzyme activity of calcineurin(CN), which is involved in cellular immunity. Manganese(Mn^<2+>) noncompetitively inhibited nickel(Ni^<2+>)-stimulated CN activity, and the rare earth lanthanum(La^<3+>) increased CN activity. Next, the influence of vanadium ion(VO)^<3->_4) on the production of interleukin-2(IL-2)(an indicator of cellular immunity) was investigated using the human T-cell line Jurkat cells. This showed that NADPH oxidase-mediated VO^<3->_4induced IL-2 production in Jurkat T-cells.
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