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Effects of oral nutritional product on inflammatory bowel disease

Research Project

Project/Area Number 21500800
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionFujita Health University

Principal Investigator

CHIHARA Takeshi  藤田保健衛生大学, 藤田記念七栗研究所, 講師 (00217241)

Co-Investigator(Renkei-kenkyūsha) SHIMPO Hiroshi  藤田保健衛生大学, 藤田記念七栗研究所, 教授 (10142580)
HIGASHIGUCHI Takashi  藤田保健衛生大学, 医学部, 教授 (40198974)
ITO Akihiro  藤田保健衛生大学, 医学部, 准教授 (50273355)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsグルタミン / 水溶性ファイバー / オリゴ糖 / デキストラン硫酸ナトリウム / 潰瘍性大腸炎 / 赤血球ポリアミン / GFO / 大腸粘膜異型腺窩巣
Research Abstract

Intractable inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are important risk factors for colon cancer, the frequency of which has increased progressively in recent years and is expected to become the leading cause of death in the next several years. Therefore, prevention and symptom improvement are key factors for decreasing colon cancer rates and improving the quality of life of these patients. We examined the effects of oral administration of a three-component mixture(GFO mixture) containing glutamine(G), soluble fiber(F) and oligosaccharide(O) on a dextran sulfate sodium(DSS)-induced ulcerative colitis model in mice. Furthermore, we investigated the effects of simultaneous administration of the GFO mixture and β-hydroxy-β-methylbutyrate(HMB), which has been reported to prevent weight loss in tumor-bearing mice(GFO+HMB mixture). As a result, both the GFO mixture and GFO+HMB mixture demonstrated slight amelioration of DSS-induced experimental colitis. However, the GFO+HMB mixture was more effective than GFO mixture. One of the mechanisms of these ameliorative effects may involve a colonic mucosal protective effect.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(2 results)

All 2011

All Presentation (2 results)

  • [Presentation] 絶食下のラット小腸粘膜に対するGFOの修飾作用2011

    • Author(s)
      千原猛、東口高志、金児孝晃、伊藤彰博、二村昭彦、定本哲郎、村井美代、大原寛之、天野晃滋、篠邊篤志、柴田賢三、園田茂、新保寛
    • Organizer
      第26回日本静脈経腸栄養学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 絶食下のラット小腸粘膜に対するGFOの修飾作用2011

    • Author(s)
      千原猛
    • Organizer
      第26回日本静脈経腸栄養学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-02-18
    • Related Report
      2010 Annual Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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