Analysis of the bioactive substances contained in the lactic acid bacteria-metabolic products from soybean milk
| Project/Area Number |
21500810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagasaki International University |
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Principal Investigator |
SAKAKIBARA Ryuzo 長崎国際大学, 薬学部・生化学研究室, 教授 (30127229)
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| Co-Investigator(Kenkyū-buntansha) |
FUKASAWA Masashi 長崎国際大学, 薬学部・生化学研究室, 准教授 (20238439)
NODAKE Yuich 長崎国際大学, 薬学部・生化学研究室, 助教 (30332282)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | バイオジェニックス / 乳酸菌 / 生理活性 / ガン / 発酵 / 肝炎 / 食品 / 癌 |
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| Research Abstract |
PS-B1 is fermented products cultivated from soybean milk using lactic acid bacteria. We found that PS-B1 inhibited significantly the growth of human leukemia HL-60 cells by the induction of apoptosis and the increase of the intracellular reactive oxygen species was important for apoptosis. In the experiments using the alcoholic injury liver model constructed by using rat hepatocytes and hepatic stellate cells, PS-B1 inhibited the necrosis of hepatocytes and suppressed the production of the collagen in hepatic stellate cells. PS-B1 also indicated the liver preservation action against the viral and drug-induced injury liver model.
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Report
(4 results)
Research Products
(24 results)
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[Presentation] 豆乳の乳酸菌発酵物が示す有用作用2010
Author(s)
野嶽勇一, 富松裕美, 中尾瑞穂, 料屋紘和, 湯浅(小島)明子, 湯浅勲, 深澤昌史, 榊原隆三
Organizer
BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会)
Place of Presentation
神戸国際会議場(神戸市)
Related Report
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[Patent(Industrial Property Rights)] 新規乳酸菌とそれを用いた肝細胞保護剤(保護成分)
Inventor(s)
榊原隆三,野嶽勇一,深澤昌史,河村俊哉,晦日房和,玉屋圭,松本周三
Industrial Property Rights Holder
榊原隆三,野嶽勇一,深澤昌史,河村俊哉,晦日房和,玉屋圭,松本周三
Related Report
