Suppressive effect of flavonoid on mast cell activation related to remodeling in asthma
Project/Area Number |
21500814
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Eating habits, studies on eating habits
|
Research Institution | National Agriculture and Food Research Organization |
Principal Investigator |
KOBORI Masuko 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 上席研究員 (50353941)
|
Research Collaborator |
NAGAI Kanji 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 契約研究員
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | フラボノイド / マスト細胞 / T細胞 / 喘息 / チロシンキナーゼ / Akt / NF-κB / 皮膚炎 / アレルギー |
Research Abstract |
Mast cell activation by cell-to-cell interaction with activated T cells has been shown to play an important role in remodeling in asthma and other inflammatory responses. The flavonoid fisetin suppressed activation of HMC-1 human mast cells by activated T cell membranes by inhibiting the Akt phosphorylation and the following activation of NF-κB and MAPKs and thereby suppressing gene expression. Adiet containing fisetin was suggested to improve the symptoms of dermatitis but not that of asthma in mice.
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Report
(4 results)
Research Products
(14 results)