• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Suppressive effect of flavonoid on mast cell activation related to remodeling in asthma

Research Project

Project/Area Number 21500814
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

KOBORI Masuko  独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 上席研究員 (50353941)

Research Collaborator NAGAI Kanji  独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 契約研究員
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsフラボノイド / マスト細胞 / T細胞 / 喘息 / チロシンキナーゼ / Akt / NF-κB / 皮膚炎 / アレルギー
Research Abstract

Mast cell activation by cell-to-cell interaction with activated T cells has been shown to play an important role in remodeling in asthma and other inflammatory responses. The flavonoid fisetin suppressed activation of HMC-1 human mast cells by activated T cell membranes by inhibiting the Akt phosphorylation and the following activation of NF-κB and MAPKs and thereby suppressing gene expression. Adiet containing fisetin was suggested to improve the symptoms of dermatitis but not that of asthma in mice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Remarks (4 results)

  • [Journal Article] The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes2009

    • Author(s)
      Kanji Nagai, Yumiko Takahashi, Ichiho Mikamim Tatsunobu Fukushima, Hideaki Oike and Masuko Kobori
    • Journal Title

      British Journal of Pharmacology 2009

      Volume: 158(3) Issue: 3 Pages: 907-919

    • DOI

      10.1111/j.1476-5381.2009.00365.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes.2009

    • Author(s)
      Nagai Kanji
    • Journal Title

      British journal of pharmacology 158(3)

      Pages: 907-919

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] グルコースがマスト細胞の活性化に及ぼす影響2012

    • Author(s)
      永井寛治、福島達伸、大池秀明、小堀真珠子
    • Organizer
      日本農芸化学会2012年度大会要旨集
    • Place of Presentation
      京都
    • Year and Date
      2012-03-23
    • Related Report
      2011 Final Research Report
  • [Presentation] グルコースがマスト細胞の活性化に及ぼす影響2012

    • Author(s)
      永井寛治, 小堀真珠子
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2012-03-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 活性化T細胞刺激によるマスト細胞活性化に対するフラボノイドの抑制効果2011

    • Author(s)
      永井寛治、福島達伸、大池秀明、小堀真珠子
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性化T細胞刺激によるマスト細胞活性化に対するフラボノイドの抑制効果2011

    • Author(s)
      永井寛治、福島達伸、大池秀明、小堀真珠子
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] グルコースのマスト細胞活性化作用2010

    • Author(s)
      永井寛治、福島達伸、大池秀明、小堀真珠子
    • Organizer
      日本食品科学工学会
    • Place of Presentation
      東京農大学
    • Year and Date
      2010-09-02
    • Related Report
      2011 Final Research Report
  • [Presentation] グルコースのマスト細胞活性化作用2010

    • Author(s)
      永井寛治、福島達伸、大池秀明、小堀真珠子
    • Organizer
      日本食品科学工学会
    • Place of Presentation
      東京農業大学(東京都)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 活性化T細胞接着刺激によるマスト細胞の活性化機構2009

    • Author(s)
      永井寛治、小堀真珠子
    • Organizer
      第39回日本免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Activated T cells induce mast cell gene expression through NF-κB pathway2009

    • Author(s)
      永井寛治
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.naro.affrc.go.jp/nfri/introduction/chart/0304/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.naro.affrc.go.jp/nfri/introduction/chart/0304/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nfri.affrc.go.jp/guidance/soshiki/kinou/kinouhyouka.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.nfri.affrc.go.jp/guidance/soshiki/kinou/kinouhyouka.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2021-08-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi