Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status

• Project/Area Number: 21500816
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: USUI Takeshi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 内分泌代謝高血圧研究部, 研究室長(臨床内分泌代謝) (20271512)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: イソフラボン / エクオール肥満 / 代謝症候群 / ダイズ / エクオール / メタボリック症候群 / 植物エストロゲン / メタボリックシンドローム

Research Abstract

The ratio of equol non-producers in overweight or obese populations might be higher than generally reported. Natural S-equol might have a role in glycemic control and in the prevention of cardiovascular disease by its effects to lower LDL-C levels and CAVI scores in overweight or obese individuals.

Research Products

• [Journal Article] Two rare TSH receptor amino acid substitutions in toxic thyroid adenomas (2012)
  • Author(s): Nanba K, Usui T, Minamiguchi S, Mori Y, Watanabe Y, Honda K, Asato R, Nakao K, Kawashima ST, Yuno A, Tamanaha T, Tagami T, Naruse M, Akiyama Y, Shimatsu A
  • Journal Title: Endocrine journal Volume: 59 Pages: 13-19
  • NAID: 10030392757
• [Journal Article] Confirmatory Testing in Primary Aldosteronism (2012)
  • Author(s): Nanba K, Tamanaha T, Nakao K, Kawashima ST, Usui T, Tagami T, Okuno H, Shimatsu A, Suzuki T, Naruse M
  • Journal Title: J Clin Endocrinol Metab
• [Journal Article] Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients (2012)
  • Author(s): Himeno A, Satoh-Asahara N, Usui T, Wada H, Tochiya M, Kono S, Yamada-Goto N, Katsuura G, Hasegawa K, Nakao K, Shimatsu A
  • Journal Title: Metabolism Volume: 61 Pages: 255-261
• [Journal Article] Two rare TSH receptor amino acid substitutions in toxic thyroid adenomas (2012)
  • Author(s): Nanba K, Usui T, Minamiguchi S, Mori Y, Watanabe Y, Honda K, Asato R, Nakao K, Kawashima ST, Yuno A, Tamanaha T, Tagami T, Naruse M, Akiyama Y, Shimatsu A
  • Journal Title: Endocrine Journal Volume: 59 Issue: 1 Pages: 13-19
  • DOI: 10.1507/endocrj.EJ11-0202
  • NAID: 130004443752
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients (2012)
  • Author(s): Himeno A, Nakao K, et al
  • Journal Title: Metabolism Volume: 61 Issue: 2 Pages: 255-261
  • DOI: 10.1016/j.metabol.2011.06.023
  • Peer Reviewed
• [Journal Article] Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status (2011)
  • Author(s): Usui T, Tochiya M, Sasaki Y, Muranaka K, Yamakage H, Himeno A, Shimatsu A, Inaguma A, Ueno T, Uchiyama S, Satoh-Asahara N
  • Journal Title: Clinical endocrinology Volume: (E pub) Issue: 3 Pages: 365-372
  • DOI: 10.1111/j.1365-2265.2012.04400.x
  • Peer Reviewed
• [Journal Article] Inheritance of an autosomal recessive disorder, Gitelman's syndrome, across two generations in one family (2011)
  • Author(s): Yagi H, Yahata K, Usui T, Hasegawa C, Seta K, Sugawara A
  • Journal Title: Intern Med Volume: 50 Pages: 1211-1214
  • NAID: 130000770474
• [Journal Article] Aberrant expression of thyroid hormone receptor beta isoform may cause inappropriate secretion of TSH in a TSH-secreting pituitary adenoma (2011)
  • Author(s): Tagami T, Usui T, Shimatsu A, Beniko M, Yamamoto H, Moriyama K, Naruse M
  • Journal Title: J Clin Endocrinol Metab Volume: 96 Pages: 948-952
• [Journal Article] Prevention of type 2 diabetes in a primary healthcare setting : three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance (2011)
  • Author(s): Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tsuzaki K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yoshida T, Kiyohara Y, Sato S, Kuzuya H
  • Journal Title: BMC Public Health Volume: 11 Pages: 40-40
• [Journal Article] Successful treatment of Cushing's disease caused by ectopic intracavernous microadenoma (2011)
  • Author(s): Koizumi M, Usui T, Yamada S, Fujisawa I, Tsuru T, Nanba K, Hagiwara H, Kimura T, Tamanaha T, Tagami T, Naruse M, Shimatsu A
  • Journal Title: Pituitary Volume: 14 Pages: 295-298
• [Journal Article] Prevention of type 2 diabetes in a primary-year rehealthcare setting : Three-year rear rezults of lifestyle in Japanese subjects with impaired glucose tolerance (2010)
  • Author(s): Naoki Sakane, Juichi Sato, Kazuyo Tsushita, Satoru Tsujii, Kazuhiko Kotani, Kokoro Tsuzaki, Makoto Tominaga, Shoji Kawazu, Yuzo Sato, Takeshi Usui, Isao Kamae, Toshihide Yoshida, Yutaka Kiyohara, Shigeaki Sato, Hideshi Kuzuya
  • Journal Title: BMC Public Health Volume: 57 Pages: 253-258
  • Peer Reviewed
• [Journal Article] R27X nonsense mutation of the SDHB gene in a patient with sporadic malignant paraganglioma. (2009)
  • Author(s): Naito M, Usui T, Tamanaha T, Kawashima ST, Iogawa H, Hagiwara H, Kimura T, Tagami T, Kurosawa M, Shimatsu A, Naruse M.
  • Journal Title: Endocrine 36 Pages: 10-15
  • Peer Reviewed
• [Journal Article] H62L Mutation of CYP21A2 Identified in the Non-classical Form of 21-Hydroxylase Deficiency. (2009)
  • Author(s): Keisuke Nagasaki, Takeshi Usui, Tadashi Asami, Yohei Ogawa, Toru Kikuchi, Makoto Uchiyama
  • Journal Title: Clinical Pediatric Endocrinology 18 Pages: 111-113
  • NAID: 10031199601
  • Peer Reviewed
• [Journal Article] P53 gene mutation in an atypical corticotroph adenoma with Cushing's disease. (2009)
  • Author(s): Kawashima ST, Usui T, Sano T, Iogawa H, Hagiwara H, Tamanaha T, Tagami T, Naruse M, Hojo M, Takahashi JA, Shimatsu A.
  • Journal Title: Clin Endocrinol 70 Pages: 656-657
  • Peer Reviewed
• [Presentation] Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status (2012)
  • Author(s): Takeshi Usui
  • Organizer: Women's Health 2012
  • Place of Presentation: Washington DC
  • Year and Date: 2012-03-17
• [Presentation] The effect of natural S-equol supplement on metabolic parameters in overwight adult Japanese males and females in equol producers and non-producers (2012)
  • Author(s): Takeshi Usui, Mayu Tochiya, Noriko Satoh-Asahara, Belinda H Jenks, Tomoni Ueno, Shigeto Uchiyama, Akirta Shimats
  • Organizer: Women's Health 2012
  • Place of Presentation: ワシントンDC
  • Year and Date: 2012-03-16
• [Presentation] The effect of Equol on Obesity and Metabolic Syndrome in Japanese, from the Standpoint of Gender and Equol Producing Capability (2010)
  • Author(s): Takeshi Usui, et al.
  • Organizer: International Symposium on the 9th Role of Soy
  • Place of Presentation: Washington, DC
  • Year and Date: 2010-10-16
• [Presentation] 肥満症における大豆イソフラボン代謝物・エクオールの産生能とエクオール投与の効果 (2010)
  • Author(s): 橡谷真由、浅原哲子、臼井健, 他3名
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 栃木
• [Presentation] The effect of equol on obesity and metabolic syndrome in Japanese, from the standpoint of gender and equol producing capability (2010)
  • Author(s): Shigeto Uchiyama, Tomomi Ueno, Asami Inaguma, Noriko Satoh-Asahara, Takeshi Usui
  • Organizer: North American Menopause Socciety
  • Place of Presentation: Chicago
• [Presentation] The effect of equol on obesity and metabolic syndrome in Japanese, from the standpoint of gender and equol producing capability (2010)
  • Author(s): Takeshi Usui, Noriko Satho-Asahara, Asami Inaguma, Tomomi Ueno, Shigeto Uchiyama
  • Organizer: 9^<th> International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment
  • Place of Presentation: Washington DC
• [Presentation] 天然SERMの分子生物学 (2009)
  • Author(s): 臼井健
  • Organizer: 第24回日本更年期医学会学術集会
  • Place of Presentation: 青森
  • Year and Date: 2009-10-03