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Studies on age-dependency of radiation-induced mutation and its mechanism

Research Project

Project/Area Number 21510053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTohoku University

Principal Investigator

UEHARA Yoshihiko  東北大学, 大学院・医学系研究科, 助教 (30223499)

Co-Investigator(Kenkyū-buntansha) ONO Tetsuya  東北大学, 大学院・医学系研究科, 教授 (00107509)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords放射線 / マウス / 被曝時年齢依存性 / 突然変異 / DNA修復 / 発がん / 被曝時年令依存性
Research Abstract

Although it is well established that radiation-induced cancer shows age-dependency at which the individuals are exposed, the mechanism responsible for it is not understood. We hypothesized that the age-dependency could be explained by a difference in the efficiency of mutation induction with radiation. Using lacZ-transgenic mice, we studied dose responses of mutation induction in liver at different ages. The efficiency changed with age but the mode of the change was different from that of cancer induction. Thus, mutation induction could not explain the age-dependency of cancer induction.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article]2010

    • Author(s)
      小野哲也
    • Journal Title

      新老年学 第3版(東京大学出版会)

      Pages: 23-29

    • Related Report
      2009 Annual Research Report
  • [Journal Article] XPC is involved in genome maintenance through multiple pathways in different tissues.2009

    • Author(s)
      Y.Uehara
    • Journal Title

      Mutation Research 670

      Pages: 24-31

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 放射線誘発突然変異のエイジ依存性2011

    • Author(s)
      小野哲也、上原芳彦、池畑広伸、小村潤一郎
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-11-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線誘発突然変異のエイジ依存性2011

    • Author(s)
      小野哲也
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸市)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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