Induction Mechanism of Genomic Instability Induced Independent of DNA Damage and the Implication on Carcinogenesis
| Project/Area Number |
21510054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | International Christian University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 放射線生物影響 / ゲノム安定性 / 染色体不均等分配 / 非変異発がん物質 / LOH / phenyl hydroquinone / hydroquinone / morphogenesis / ヘテロ接合生喪失 / dimethyl sulfoxide / 染色体異数化 / 非変異・発がん物質 / Hog1-Swe1 pathway / morphogenesis checkpoint / 遺伝的不安定化 / 非変異原性発がん物質 / Aneuploidy / 細胞周期 / 細胞がん化 / 出芽酵母 |
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| Research Abstract |
Hydroquinone(HQ), which is the metabolite of the non-mutagenic carcinogen, benzene, induced loss of heterozygosity(LOH), through chromosomal mis-segrigation. HQ interacted to tubulin, interfered valance between polymerization/dissociation during microtubule formation, and activated Hog1-Swe1 morphogenesis checkpoint, suggesting that LOH induced by HQ is implicated in these characteristics of HQ. By using the LOH detection system, various iron beams with different LET also induced LOH through homologous recombination.
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Report
(4 results)
Research Products
(29 results)
