Functional analysis of CUL4/DDB1 ubiquitin E3 ligase in DNA damage response
| Project/Area Number |
21510055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNAGA Tsukasa 金沢大学, 薬学系, 教授 (60192340)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ゲノム / シグナル伝達 / DNA損傷応答 / ユビキチン / DNA修復 / クロマチン |
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| Research Abstract |
The Cul4/DDB1 complex is a recently identified culling-RING ubiquitin ligase, which regulates DNA repair, DNA replication and transcription. We analyzed the potential functions of DDB1 in the responses to various DNA damaging agents using a conditional knockout DT40 cells. Furthermore, we found that the interaction between DDB1 and Cul4 is absolutely required for cell viability, suggesting an essential role of DDB1 as a component of Cul4/DDB1 ubiquitin E3 ligase.
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Report
(4 results)
Research Products
(48 results)
