Novel insights into the effect protecting DNA from radiation-induced damage : identification of relevant factors involved in paracrine epithelial-mesenchymal cell interactions
| Project/Area Number |
21510057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAENKO Vladimir 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30343346)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Masahiro 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50284683)
MITSUTAKE Norisato 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50404215)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 放射線 / DNA損傷 / 二重鎖切断 / リン酸化H2AX / 上皮/間質細胞間相互作用 / パラクライン因子 / サイトカイン / 上皮 / 間質細胞間相互作用 |
|---|
| Research Abstract |
Normal epithelial and mesenchymal cells maintain paracrine cross-talk through secreted soluble factors. One of the observed outcomes of these intercellular interactions is the modulation(decrease) of the extent of radiation-induced DNA damage in both types of cells after reciprocal treatment with heterologous conditioned medium. Soluble factors secreted into medium are presumably a part of the conserved network of paracrine factors operating in a background mode that does not require any special pretreatment of the cells for induction. This study attempted to indentify such soluble factors particularly focusing on cytokines produced by primary thyroid epithelial cells and normal human fibroblasts as a model, and elucidation of the mechanism by which genotoxic insult is diminished.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancer2011
Author(s)
Rumyantsev PO, Saenko VA, Ilyin AA, Stepanenko VF, Rumyantseva UV, Abrosimov AY, Lushnikov EF, Rogounovitch TI, Shibata Y, Mitsutake N, Tsyb AF, Yamashita S.
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Journal Title
J Clin Endocrinol Metab
Volume: 96(2)
Pages: 385-393
NAID
Related Report
Peer Reviewed
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[Journal Article] Thyroid cancer incidence in Ukraine : trends with reference to the Chernobyl accident2011
Author(s)
Fuzik M, Prysyazhnyuk A, Shibata Y, Romanenko A, Fedorenko Z, Gulak L, Goroh Y, Gudzenko N, Trotsyuk N, Khukhrianska O, Saenko V, Yamashita S
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Journal Title
Radiation Environ Biophys
Volume: 50(1)
Pages: 47-55
NAID
Related Report
Peer Reviewed
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[Journal Article] Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia2011
Author(s)
Stanojevic B, Dzodic R, Saenko V, Milovanovic Z, Pupic G, Zivkovic O, Markovic I, Djurisic I, Buta M, Dimitrijevic B, Rogounovitch T, Mitsutake N, Mine M, Shibata Y, Nakashima M, Yamashita S
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Journal Title
Endocr J
Volume: 58(5)
Pages: 381-393
NAID
Related Report
Peer Reviewed
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[Presentation] Molecular epidemiology study of Chernobyl thyroid cancer2011
Author(s)
V Saenko, M Takahashi, T Rogounovitch, T Kawaguchi, V Drozd, N Akulevich, L Danilova, Yu Demidchik, M Lushchik, N Mitsutake, R Yamada, M Lathrop, F Matsuda, S Yamashita
Organizer
14^<th> International Congress of Radiation Research
Place of Presentation
Poland
Year and Date
2011-09-01
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