Novel insights into the effect protecting DNA from radiation-induced damage : identification of relevant factors involved in paracrine epithelial-mesenchymal cell interactions

• Project/Area Number: 21510057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Nagasaki University
• Principal Investigator: SAENKO Vladimir 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30343346)
• Co-Investigator(Kenkyū-buntansha): NAKASHIMA Masahiro 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50284683) ; MITSUTAKE Norisato 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50404215)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 放射線 / DNA損傷 / 二重鎖切断 / リン酸化H2AX / 上皮/間質細胞間相互作用 / パラクライン因子 / サイトカイン / 上皮 / 間質細胞間相互作用

Research Abstract

Normal epithelial and mesenchymal cells maintain paracrine cross-talk through secreted soluble factors. One of the observed outcomes of these intercellular interactions is the modulation(decrease) of the extent of radiation-induced DNA damage in both types of cells after reciprocal treatment with heterologous conditioned medium. Soluble factors secreted into medium are presumably a part of the conserved network of paracrine factors operating in a background mode that does not require any special pretreatment of the cells for induction. This study attempted to indentify such soluble factors particularly focusing on cytokines produced by primary thyroid epithelial cells and normal human fibroblasts as a model, and elucidation of the mechanism by which genotoxic insult is diminished.

Research Products

• [Journal Article] Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancer (2011)
  • Author(s): Rumyantsev PO, Saenko VA, Ilyin AA, Stepanenko VF, Rumyantseva UV, Abrosimov AY, Lushnikov EF, Rogounovitch TI, Shibata Y, Mitsutake N, Tsyb AF, Yamashita S.
  • Journal Title: J Clin Endocrinol Metab Volume: 96(2) Pages: 385-393
  • NAID: 120006985168
  • Peer Reviewed
• [Journal Article] Thyroid cancer incidence in Ukraine : trends with reference to the Chernobyl accident (2011)
  • Author(s): Fuzik M, Prysyazhnyuk A, Shibata Y, Romanenko A, Fedorenko Z, Gulak L, Goroh Y, Gudzenko N, Trotsyuk N, Khukhrianska O, Saenko V, Yamashita S
  • Journal Title: Radiation Environ Biophys Volume: 50(1) Pages: 47-55
  • NAID: 120006984894
  • Peer Reviewed
• [Journal Article] Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction (2011)
  • Author(s): Suzuki K, Mitsutake N, Saenko V(他8名)
  • Journal Title: PLoS One Volume: 6(4)
  • NAID: 120006985082
  • Peer Reviewed
• [Journal Article] The Chernobyl accident and its consequences (2011)
  • Author(s): Saenko V(他6名)
  • Journal Title: Clin Oncol Volume: 23(4) Pages: 234-243
  • Peer Reviewed
• [Journal Article] Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia (2011)
  • Author(s): Stanojevic B, Dzodic R, Saenko V, Milovanovic Z, Pupic G, Zivkovic O, Markovic I, Djurisic I, Buta M, Dimitrijevic B, Rogounovitch T, Mitsutake N, Mine M, Shibata Y, Nakashima M, Yamashita S
  • Journal Title: Endocr J Volume: 58(5) Pages: 381-393
  • NAID: 10029588652
  • Peer Reviewed
• [Journal Article] The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population (2011)
  • Author(s): Matsuse M, Takahashi M, Mitsutake N, Nishihara E, Hirokawa M, Kawaguchi T, Rogounovitch T, Saenko V(他8名)
  • Journal Title: J Med Genet Volume: 48(9) Pages: 645-648
  • NAID: 120006985044
  • Peer Reviewed
• [Journal Article] Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction (2011)
  • Author(s): Suzuki K, et al
  • Journal Title: PLoS One Volume: 6 Issue: 4 Pages: e19354-e19354
  • DOI: 10.1371/journal.pone.0019354
  • Peer Reviewed
• [Journal Article] The Chernobyl accident and its consequences (2011)
  • Author(s): Saenko V, et al
  • Journal Title: Clin Oncol Volume: 23 Issue: 4 Pages: 234-243
  • DOI: 10.1016/j.clon.2011.01.502
  • Peer Reviewed
• [Journal Article] Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia (2011)
  • Author(s): Stanojevic B, et al
  • Journal Title: Endocrine Journal Volume: 58 Issue: 5 Pages: 381-393
  • DOI: 10.1507/endocrj.K11E-054
  • NAID: 130004443699
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population (2011)
  • Author(s): Matsuse M, et al
  • Journal Title: J Med Genet Volume: 48 Pages: 645-648
  • Peer Reviewed
• [Journal Article] Radioactive iodine and thyroid cancer (2011)
  • Author(s): Vladimir Saenko, et al
  • Journal Title: Endocrine Disrupter NEWS LETTER Volume: 14 Pages: 5-5
• [Journal Article] Radiation exposure does not significantly contribute to the risk of Recurrence of Chernobyl thyroid cancer (2011)
  • Author(s): Rumyantsev PO, et al.
  • Journal Title: J Clin Endocrinol Metab Volume: 96 Pages: 385-393
  • Peer Reviewed
• [Journal Article] Thyroid cancer incidence in Ukraine : trends with reference to the Chernobyl accident (2011)
  • Author(s): Fuzik M, et al.
  • Journal Title: Radiation Environ Biophys Volume: 50 Pages: 47-55
  • Peer Reviewed
• [Journal Article] Effect of Paclitaxel and combination of the drug with radiation therapy in an in vivo model of anaplastic thyroid carcinoma (2011)
  • Author(s): Pushkarev VM, et al.
  • Journal Title: Exp Oncol Volume: 33 Pages: 24-27
  • Peer Reviewed
• [Journal Article] Intraductal Papilloma of Ectopic Breast Tissue in Axillary Lymph Node of a Patient with a Previous Intraductal Papilloma of Ipsilateral Breast : a case report and review of the literature (2010)
  • Author(s): Dzodic R, Stanojevic B, Saenko V, Nakashima M(他6名)
  • Journal Title: Diagn Pathol Volume: 5(1) Pages: 17-17
  • Peer Reviewed
• [Journal Article] The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl (2010)
  • Author(s): Takahashi M, Saenko VA, Rogounovitch TI, Kawaguchi T, Drozd VM, Takigawa-Imamura H, Akulevich NM, Ratanajaraya C, Mitsutake N(他9名)
  • Journal Title: Hum Mol Genet Volume: 19(12) Pages: 2516-2523
  • NAID: 120006984984
  • Peer Reviewed
• [Journal Article] Chernobyl thyroid cancer 25 years after : in search of a molecular radiation signature (2010)
  • Author(s): Saenko V, Yamashita S
  • Journal Title: Hot Thyroidology Volume: 8 Pages: 10-10
  • Peer Reviewed
• [Journal Article] The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl (2010)
  • Author(s): Takahashi M, et al.
  • Journal Title: Hum Mol Genet Volume: 19 Pages: 2516-2523
  • Peer Reviewed
• [Journal Article] miR-195, miR-455-3q and miR-10a(*) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells. (2010)
  • Author(s): Ujifuku K, et al.
  • Journal Title: Cancer Lett Volume: 296 Pages: 241-248
  • Peer Reviewed
• [Journal Article] Molecular epidemiology study of radiation-induced thyroid cancer as a main research project of Representative office of Nagasaki University in Belarus (2010)
  • Author(s): Rogounovitch T, et al.
  • Journal Title: 長崎医学会雑誌 Volume: 85 Pages: 179-181
• [Journal Article] Chernobyl thyroid cancer 25 years after : in search of a molecular Radiation signature (2010)
  • Author(s): Saenko V, et al.
  • Journal Title: Hot Thyroidology
  • Peer Reviewed
• [Journal Article] Intraductal Papilloma of Ectopic Breast Tissue in Axillary Lymph Node of a Patient with a Previous Intraductal Papilloma of Ipsilateral Breast : a case report and review of the literature. (2010)
  • Author(s): Dzodic R, et al.
  • Journal Title: Diagnostic Pathology 5 Pages: 17-17
  • Peer Reviewed
• [Journal Article] Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma (2009)
  • Author(s): Akulevich N, Saenko V, Rogounovitch T, Drozd V, Lushnikov E, Ivanov V, Mitsutake N, Kominami R, Yamashita S
  • Journal Title: Endocr Relat Cancer Volume: 16(2) Pages: 491-503
  • NAID: 120006984014
  • Peer Reviewed
• [Journal Article] Mutation analysis of RAP1 gene in papillary thyroid carcinomas. (2009)
  • Author(s): Matsuse M, et al.
  • Journal Title: Endocr J 56 Pages: 161-164
  • Peer Reviewed
• [Journal Article] Effects of low and high concentrations of antitumour drug taxol in anaplastic thyroid cancer cells. (2009)
  • Author(s): Pushkarev VM, et al.
  • Journal Title: Exp Oncol 31 Pages: 16-21
  • Peer Reviewed
• [Journal Article] Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. (2009)
  • Author(s): Akulevich N, et al.
  • Journal Title: Endocr Relat Cancer 16 Pages: 491-503
  • Peer Reviewed
• [Journal Article] The usual ultrasonographic features of thyroid cancer are less frequent in small tumors that develop after a long latent period after the Chernobyl radiation release accident. (2009)
  • Author(s): Drozd VM, et al.
  • Journal Title: Thyroid 19 Pages: 725-734
  • Peer Reviewed
• [Journal Article] Lack of GNAQ hotspot mutation in papillary thyroid carcinomas. (2009)
  • Author(s): Matsuse M, et al.
  • Journal Title: Thyroid 19 Pages: 921-922
  • Peer Reviewed
• [Presentation] 甲状腺乳頭癌症例で検出された新規BRAF変異(BRAF^<V600Y+M601Ins>)の機能解析 (2011)
  • Author(s): 松瀬美智子
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 2011-11-23
• [Presentation] Identification of genes cooperating with BRAF in thyroid carcinogenesis by retroviral insertional mutagenesis (2011)
  • Author(s): ログノビッチ タチアナ
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 2011-11-23
• [Presentation] Immunohistochemical study of FOXE1 expression in PTC (2011)
  • Author(s): ビチコブ アンドレイ
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 2011-11-23
• [Presentation] EOXE1及びNKK2-1ローカスにおける遺伝子多型は日本人甲状腺乳頭癌に関連する遺伝的因子である (2011)
  • Author(s): 松瀬美智子
  • Organizer: 第54回日本甲状腺学会学術総会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 2011-11-22
• [Presentation] Molecular epidemiology study of radiation-induced papillary thyroid carcinoma after Chernobyl (2011)
  • Author(s): サエンコウラジミール
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2011-11-21
• [Presentation] Molecular epidemiology study of radiation-induced papillary thyroid carcinoma after Chernobyl (2011)
  • Author(s): サエンコ ウラジミール
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 2011-11-21
• [Presentation] Molecular epidemiology study of Chernobyl thyroid cancer from Belarus and Ukraine (2011)
  • Author(s): Saenko Vladimir
  • Organizer: The 6th International Symposium on A New Challenge of Radiation Health Risk Management
  • Place of Presentation: Nagasaki
  • Year and Date: 2011-10-21
• [Presentation] Molecular epidemiology study of Chernobyl thyroid cancer from Belarus and Ukraine (2011)
  • Author(s): Saenko Vladimir
  • Organizer: The 6^<th> International Symposium on A New Challenge of Radiation Health Risk Management
  • Place of Presentation: 長崎大学良順会館(長崎県)
  • Year and Date: 2011-10-21
• [Presentation] Molecular epidemiology study of Chernobyl thyroid cancer (2011)
  • Author(s): V Saenko, M Takahashi, T Rogounovitch, T Kawaguchi, V Drozd, N Akulevich, L Danilova, Yu Demidchik, M Lushchik, N Mitsutake, R Yamada, M Lathrop, F Matsuda, S Yamashita
  • Organizer: 14^<th> International Congress of Radiation Research
  • Place of Presentation: Poland
  • Year and Date: 2011-09-01
• [Presentation] Molecular and clinico-pathological analysis of sporadic pediatric thyroid cancers in Belarus (2011)
  • Author(s): T Rogounovitch, V Saenko, S Mankovskaya, M Fridman, M Matsuse, N Mitsutake, Y Demidchik, S Yamashita
  • Organizer: 14^<th> International Congress of Radiation Research
  • Place of Presentation: Poland
  • Year and Date: 2011-09-01
• [Presentation] Molecular epidemiology study of Chernobyl thyroid cancer (2011)
  • Author(s): Saenko Vladimir
  • Organizer: 14^<th> International Congress of Radiation Research
  • Place of Presentation: The Palace of Culture and Science (Poland)
  • Year and Date: 2011-09-01
• [Presentation] Molecular and clinico-pathological analysis of sporadic pediatric thyroid cancers in Belarus (2011)
  • Author(s): Rogounovitch Tatiana
  • Organizer: 14^<th> International Congress of Radiation Research
  • Place of Presentation: The Palace of Culture and Science (Poland)
  • Year and Date: 2011-09-01
• [Presentation] Molecular genetic signatures of radiation-related thyroid cancer (2011)
  • Author(s): サエンコウラジミール
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2011-04-23
• [Presentation] Molecular genetic signatures of radiation-related thyroid cancer (2011)
  • Author(s): サエンコ ウラジミール
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際会議場・神戸国際展示場(兵庫県)
  • Year and Date: 2011-04-23
• [Presentation] High-throughput retroviral tagging to identify genes and signaling path ways cooperating with BRAF in thyroid carcinogenesis (2011)
  • Author(s): ログノビッチ タチアナ
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際会議場・神戸国際展示場(兵庫県)
  • Year and Date: 2011-04-21
• [Presentation] The Japanese study of BRAF mutation in childhood PTC using CTB materials : around and beyond (2011)
  • Author(s): Saenko Vladimir
  • Organizer: 7^<th> NCRI Cancer Conference
  • Place of Presentation: UK
• [Presentation] Immunohistochemical study of FOXE1 expression in PTC (2011)
  • Author(s): ビチコブアンドレイ, サエンコウラジミール, ログノビッチタチアナ, 中島正洋, 光武範吏, 山下俊一
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪
• [Presentation] The Japanese study of BRAF mutation in childhood PTC using CTB materials : around and beyond (2011)
  • Author(s): Saenko Vladimir
  • Organizer: 7^<th> NCRI Cancer Conference
  • Place of Presentation: BT Convention Centre, Liverpool (UK)(招待講演)
• [Presentation] Comparative pathological analysis of papillary thyroid carcinoma in agematched groups of patients born before and after Chernobyl (2011)
  • Author(s): Bogdanova Tatiana
  • Organizer: 7^<th> NCRI Cancer Conference
  • Place of Presentation: BT Convention Centre, Liverpool (UK)
• [Presentation] Molecular epidemiological study of radiation-induced thyroid cancer (2010)
  • Author(s): Vladimir Saenko
  • Organizer: 125^<th> Anniversary Conference on Biomedical Sciences between SPB-MAPO and Nagasaki University
  • Place of Presentation: St.Petersburg, Russia
  • Year and Date: 2010-06-10
• [Presentation] Molecular epidemiology study of radiation-induced thyroid cancer as a main research project of Representative office of Nagasaki University in Belarus (2010)
  • Author(s): Tatiana Rogounovitch
  • Organizer: 第51回原子爆弾後障害研究会
  • Place of Presentation: 長崎
  • Year and Date: 2010-06-06
• [Presentation] Molecular signature of radiation induced thyroid tumors (2010)
  • Author(s): Vladimir Saenko
  • Organizer: 14^<th> International Thyroid Congress
  • Place of Presentation: France
• [Presentation] DNA damage response genes as genetic factors modifying risk of radiation-related thyroid cancer (2010)
  • Author(s): V Saenko, T Rogounovitch, M Takahashi, C Ratanajaraya, N Mitsutake, V Drozd, F Matsuda, S Yamashita
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: Kyoto
• [Presentation] Molecular epidemiology study of papillary thyroid carcinoma developing after internal exposure to radioiodine in Chernobyl (2010)
  • Author(s): ウラジミールサエンコ
  • Organizer: 第53回日本甲状腺学会学術集会
  • Place of Presentation: 長崎
• [Presentation] Molecular signatures of radiation-related thyroid cancer (2010)
  • Author(s): サエンコウラジミール, 高橋めい子, ログノビッチタチアナ, 光武範吏, 松田文彦, 山下俊一
  • Organizer: 第53回日本甲状腺学会学術集会
  • Place of Presentation: 長崎
• [Presentation] 甲状腺微小乳癌での53BP1発現の意義:BRAF遺伝子変異とリンパ節転移との関連 (2010)
  • Author(s): ムサジャノワジャンナ, サエンコウラジミール, 成毛有紀, 鈴木啓司, 光武範吏, 伊東正博, 西原永潤, 廣川満良, 山下俊一, 中島正洋
  • Organizer: 第53回日本甲状腺学会学術集会
  • Place of Presentation: 長崎
• [Presentation] Molecular signature of radiation induced thyroid tumors (2010)
  • Author(s): Vladimir Saenko
  • Organizer: 14^<th> International Thyroid Congress
  • Place of Presentation: Paris, France
• [Presentation] Imatinib, the selective tyrosine kinase inhibitor, enhances antitumor activity of docetaxel in anaplastic thyroid cancer cells (2010)
  • Author(s): Matsuse Michiko
  • Organizer: 14^<th> International Thyroid Congress
  • Place of Presentation: Paris, France
• [Presentation] Significance of 53BP1 expression in thyroid papillary microcarcinoma and correlation analysis between BRAF mutation and nodal metastasis (2010)
  • Author(s): Mussazhanova Zhanna
  • Organizer: 14^<th> International Thyroid Congress
  • Place of Presentation: Paris, France
• [Presentation] Molecular and clinico-pathological analysis of sporadic pediatric thyroid cancers in Belarus (2010)
  • Author(s): Rogounovitch Tatiana
  • Organizer: 14^<th> International Thyroid Congress
  • Place of Presentation: Paris, France
• [Presentation] Clinical course of four pediatric patients with congenital hypothyroidism harboring novel mutations in the TSHR gene (2010)
  • Author(s): Kiyaev A
  • Organizer: 14^<th> International Thyroid Congress
  • Place of Presentation: Paris, France
• [Presentation] The impact of a unique nonsense mutation in the THRB1 gene, E457X, on resistance to thyroid hormone complexities (2010)
  • Author(s): Akulevich N
  • Organizer: 14^<th> International Thyroid Congress
  • Place of Presentation: Paris, France
• [Presentation] Short-term predictors of euthyroidism after radioiodine therapy for functional autonomy of the thyroid. (2010)
  • Author(s): ワルエビッチ ビクトル
  • Organizer: 第53回日本甲状腺学会学術集会
  • Place of Presentation: 長崎
• [Presentation] Molecular and clinical characteristics of sporadic childhood thyroid cancers (2010)
  • Author(s): ログノビッチ タチアナ
  • Organizer: 第53回日本甲状腺学会各術集会
  • Place of Presentation: 長崎
• [Presentation] Imatinib, the selective tyrosine kinase inhibitor, enhances antitumor activity of docetaxel in anaplastic thyroid cancer cells (2010)
  • Author(s): キム ウンスク
  • Organizer: 第53回日本甲状腺学会学術集会
  • Place of Presentation: 長崎
• [Presentation] Synergistic Effect of 17-Allylamino-17-Demethoxygeldanamycin with Dehydroxymethylepoxyequinomicin on thyroid cancer cell (2010)
  • Author(s): スタノエビッチ ボバン
  • Organizer: 第53回日本甲状腺学会学術集会
  • Place of Presentation: 長崎
• [Presentation] Simultaneous determination of tumor clonality and mutant BRAF oncogene detects the molecular diversity of papillary thyroid carcinoma (2010)
  • Author(s): Rogounovitch Tatiana
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 京都
• [Presentation] DNA damage response genes as genetic factors modifying risk of Radiation-related thyroid cancer (2010)
  • Author(s): Saenko Vladimir
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 京都
• [Presentation] A unique nonsense mutation in THRB1 gene, E457X, in a patient with resistance to thyroid hormone (2010)
  • Author(s): Akulevich Natallia
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 京都
• [Presentation] Mutational and clinicopathological analysis of papillary thyroid carcinoma in Serbian patients (2010)
  • Author(s): Stanojevic Boban
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 京都
• [Presentation] Thyroid nodular pathology in patients with and without acromegaly. (2010)
  • Author(s): Danilova Larisa
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 京都
• [Presentation] Molecular diversity of papillary thyroid carcinoma assessed by simultaneous determination of tumor clonality and somatic oncogenic mutation (2009)
  • Author(s): Saenko V, Rogounovitch T, Abrosimov A, Furminskaya E, Lushnikov E, Mitsutake N, Yamashita S
  • Organizer: 9^<th> Asia and Oceania Thyroid Association Congress
  • Place of Presentation: Aichi
• [Presentation] A mechanism of molecular diversity of monoclonal papillary thyroid carcinomas (2009)
  • Author(s): ログノビッチタチアナ, サエンコウラジミール, アブロシモフアレクサンダー, フルミンスカヤエレーナ, ルシニコフエウゲニ, 光武範吏, 山下俊一
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 愛知
• [Presentation] Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma (2009)
  • Author(s): Saenko VA, Akulevich NM, Rogounovitch TI, Drozd VM, Lushnikov EF, Yamashita S
  • Organizer: International Symposium on Chernobyl Health Effects 2009
  • Place of Presentation: Belarus
• [Presentation] Assessment of molecular diversity of papillary thyroid carcinoma by simultaneous determination of tumor clonality and somatic oncogenic mutation (2009)
  • Author(s): Rogounovitch TI, Saenko VA, Abrosimov AY, Furminskaya EV, Lushnikov EF, Mitsutake N, Yamashita S
  • Place of Presentation: Belarus
• [Presentation] Preoperative Diagnostics of Thyroid Nodules by Molecular Analysis of FNAB Materials. (2009)
  • Author(s): Mankovskaya Svetlana
  • Organizer: 6^<th> ISABS Conference on Human Genome Project Based Applications in Forensic Science, Anthropology and Individualized Medicine
  • Place of Presentation: Split, Croatia
• [Presentation] A novel truncating mutation in the THRB1 gene, E457X, as a cause of resistance to thyroid hormone. (2009)
  • Author(s): Akulevich Natallia
  • Organizer: 9^<th> Asia and Oceania Thyroid Association Congress
  • Place of Presentation: 名古屋
• [Presentation] Molecular diversity of papillary thyroid carcinoma assessed by simultaneous determination of tumor clonality and somatic oncogenic mutation. (2009)
  • Author(s): Saenko Vladimir
  • Organizer: 9^<th> Asia and Oceania Thyroid Association Congress
  • Place of Presentation: 名古屋
• [Presentation] Mutational and chnico-pathological analysis of papillary thyroid carcinoma in Serbian patients. (2009)
  • Author(s): Stanojevic Boban
  • Organizer: 9^<th> Asia and Oceania Thyroid Association Congress
  • Place of Presentation: 名古屋
• [Presentation] Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. (2009)
  • Author(s): Saenko Vladimir
  • Organizer: International Symposium on Chernobyl Health Effects 2009
  • Place of Presentation: Minsk, Belarus
• [Presentation] Pediatric thyroid carcinomas in Belarus. (2009)
  • Author(s): Demidchik Yuri
  • Organizer: International Symposium on Chernobyl Health Effects 2009
  • Place of Presentation: Minsk, Belarus
• [Presentation] Clinical features of sporadic and radiation-induced papillary thyroid cancer in children, adolescents and young adults in Russia. (2009)
  • Author(s): Rumyantsev Pavel
  • Organizer: International Symposium on Chernobyl Health Effects 2009
  • Place of Presentation: Minsk, Belarus
• [Presentation] Efficacy of molecular tests in initial diagnosis of thyroid nodules. (2009)
  • Author(s): Mankovskaya Svetlana
  • Organizer: International Symposium on Chernobyl Health Effects 2009
  • Place of Presentation: Minsk, Belarus
• [Presentation] Assessment of molecular diversity of papillary thyroid carcinoma by simultaneous determination of tumor clonality and somatic oncogenic mutation. (2009)
  • Author(s): Rogounovitch Tatiana
  • Organizer: International Symposium on Chernobyl Health Effects 2009
  • Place of Presentation: Minsk, Belarus
• [Presentation] Efficacy of molecular tests in diagnosis of papillary thyroid carcinoma (2009)
  • Author(s): Mankovskaya Svetlana
  • Organizer: BIT Life Sciences 3^<rd> Annual Word Congress of Gene 2009
  • Place of Presentation: Beijing, China
• [Presentation] Clinical course of papillary thyroid carcinoma in children and adolescent age groups. (2009)
  • Author(s): Rumyantsev Pavel
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬
• [Presentation] Efficient preoperative evaluation of thyroid nodules by molecular analysis of FNAB materials. (2009)
  • Author(s): Saenko Vladimir
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬
• [Presentation] 甲状腺乳頭癌におけるGNAQ遺伝子変異 (2009)
  • Author(s): 松瀬美智子
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 名古屋
• [Presentation] A mechanism of molecular diversity of monoclonal papillary thyroid cartinomas (2009)
  • Author(s): ログノビッチ タチアナ
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 名古屋
• [Remarks]
  • URL: http://www.med.nagasaki-u.ac.jp/renew/information/interna_heal_j/
• [Remarks]
  • URL: http://www.med.nagasaki-u.ac.jp/renew/information/interna_heal_j/