Molecular mechanisms for radioadaptive responses
| Project/Area Number |
21510060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
NENOI Mitsuru 独立行政法人放射線医学総合研究所, 放射線防護研究センター, プログラムリーダー (10164659)
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| Co-Investigator(Kenkyū-buntansha) |
WANG Bing 独立行政法人放射線医学総合研究所, 放射線防護研究センター, チームリーダー (10300914)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 応答 / 放射線適応応答 / 低線量放射線 / 放射線障害 / 適応応答 / マイクロアレイ / RNA干渉 |
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| Research Abstract |
The radioadaptive response is defined as a biological response by which cells or animals acquire resistance against subsequent high dose radiation. In this research, we showed that the radioadaptive response of human lymphoblastoid cells in terms of radiation-induced mutation was associated with activation of a DNA repair system with high fidelity, and that the response was not primarily related to regulation of the cell cycle or apoptosis. In addition, we showed that the radioadaptive response of fetal mice in terms of radiation-induced prenatal death and teratogenesis was functionally associated with Tead3, Csf1 and Cacna1a genes.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article]2009
Author(s)
根井充
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Journal Title
Microarray analysis of altered gene expression in the kidney of mice exposed to radiation. In "DNA : Fingerprinting, Sequencing and Chips"(Nova Science Publishers, Inc., Hauppauge NY)
Pages: 133-143
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