| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The radioadaptive response is defined as a biological response by which cells or animals acquire resistance against subsequent high dose radiation. In this research, we showed that the radioadaptive response of human lymphoblastoid cells in terms of radiation-induced mutation was associated with activation of a DNA repair system with high fidelity, and that the response was not primarily related to regulation of the cell cycle or apoptosis. In addition, we showed that the radioadaptive response of fetal mice in terms of radiation-induced prenatal death and teratogenesis was functionally associated with Tead3, Csf1 and Cacna1a genes.
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