| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The toxic metal, cadmium, damages renal proximal tubular cells. We, therefore, examined the protective effects of salubrinal, a suppressor of endoplasmic reticulum stress, on apoptotic cell death in HK-2 human proximal tubular cells exposed to cadmium. Treatment with salubrinal protected cadmium-exposed HK-2 cells from apoptosis by increasing the phosphorylation of translation initiation factor, eIF2α, and suppressing cell death signal transduction pathways. Endoplasmic reticulum may function as a stress sensor to toxic metals exposure.
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