Effects of environmental chemicals on synapse formation and gene expression using primary brain culture.
| Project/Area Number |
21510075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | 財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2009-2010) |
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Principal Investigator |
KURODA Junko (KIMURA Junko) 財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 副参事研究員 (20142151)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANO Hitoshi 財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 副参事研究員 (20161341)
KURODA Yoichiro 財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 副参事研究員 (30073084)
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| Research Collaborator |
KOMUTA Yukari 財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員 (60566850)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 環境化学物質 / 脳発達 / 神経毒性 / シナプス形成 / 培養神経細胞 / 農薬ネオニコチノイド / 脳・神経 |
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| Research Abstract |
The neonicotinoids belong to a new, widely used class of pesticide. With similar chemical structures to nicotine, neonicotinoids also share agonist activity at nicotinic acetylcholine receptors(nAChRs). Although their toxicities against insects are well established, their precise effects on mammalian nAChRs remain to be elucidated. Because of the importance of nAChRs for mammalian brain function, especially brain development, detailed investigation of the neonicotinoids is needed to protect the health of human children. Our study shows that neonicotinoids and nicotine exert similar excitatory effects on mammalian nAChRs of cultured cerebellar neurons from neonatal rats at concentrations greater than 1μM. Using this in vitro model system, it is proposed that the neonicotinoids adversely influences human health, especially the brain of children.
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Report
(4 results)
Research Products
(25 results)
