Development of a novel minimally invasive treatment of cancer using magnetic nanoparticles to recognize molecular target and energy
| Project/Area Number |
21510116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Ehime University |
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Principal Investigator |
WATANABE Yuji 愛媛大学, 大学院・医学系研究科, 教授 (20210958)
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| Co-Investigator(Kenkyū-buntansha) |
NAOHARA Takashi 愛媛大学, 理工学研究科, 准教授 (50093935)
MAEHARA Tsunehiro 愛媛大学, 理工学研究科, 教授 (40274302)
AONO Hiromichi 愛媛大学, 理工学研究科, 准教授 (00184052)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 誘導加熱 / 温熱療法 / モノクロナール抗体 / DDS / リポソーム / 化学療法 / 蛍光標識 / ドセタキセル / 分子標的治療 / 温熱化学療法 / ナノ磁性粒子 / Her2/neu / 発熱磁性体 / マグネタイト |
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| Research Abstract |
Tumor model was achieved by implantation of human breast cancer cell line(BT474, SKBr3) under the fascia of the lower leg of nude mouse. Liposomes bound to antibody could be adjusted and kept stable below 100nm in diameter contained anticancer drugs inside, sealed between lipid bilayer(FeFe204) magnetite. In the group given antibody, chemical and thermal, such systemic therapy showed not only a reduction in tumor size but also a therapeutic effect against the lymph node metastases. As described above, the planned research purposes could be achieved.
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Report
(4 results)
Research Products
(26 results)
