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Development of a novel minimally invasive treatment of cancer using magnetic nanoparticles to recognize molecular target and energy

Research Project

Project/Area Number 21510116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionEhime University

Principal Investigator

WATANABE Yuji  愛媛大学, 大学院・医学系研究科, 教授 (20210958)

Co-Investigator(Kenkyū-buntansha) NAOHARA Takashi  愛媛大学, 理工学研究科, 准教授 (50093935)
MAEHARA Tsunehiro  愛媛大学, 理工学研究科, 教授 (40274302)
AONO Hiromichi  愛媛大学, 理工学研究科, 准教授 (00184052)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords誘導加熱 / 温熱療法 / モノクロナール抗体 / DDS / リポソーム / 化学療法 / 蛍光標識 / ドセタキセル / 分子標的治療 / 温熱化学療法 / ナノ磁性粒子 / Her2/neu / 発熱磁性体 / マグネタイト
Research Abstract

Tumor model was achieved by implantation of human breast cancer cell line(BT474, SKBr3) under the fascia of the lower leg of nude mouse. Liposomes bound to antibody could be adjusted and kept stable below 100nm in diameter contained anticancer drugs inside, sealed between lipid bilayer(FeFe204) magnetite. In the group given antibody, chemical and thermal, such systemic therapy showed not only a reduction in tumor size but also a therapeutic effect against the lymph node metastases. As described above, the planned research purposes could be achieved.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (5 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Heat Generation Ability in AC Magnetic Field and Their Computer Simulation for Ti Tube Filled with Ferrite Powder2011

    • Author(s)
      H. Aono, T. Naohara, Y. Watanabe
    • Journal Title

      Journal of Magnetism and Magnetic Materials

      Volume: 323 Pages: 88-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of tailored, selective and effective anticancer chemotherapy by direct injection of docetaxel-loaded immunoliposomes into Her2/neu positive gastric tumor xenografts2011

    • Author(s)
      Y. Yamamoto, Y. Watanabe
    • Journal Title

      International Journal of Oncology

      Volume: 38 Pages: 33-39

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat generation ability in AC magnetic field of nano MgFe2O4-based ferrite powder prepared by bead milling2011

    • Author(s)
      H. Aono, T. Naohara, Y. Watanabe
    • Journal Title

      Journal of Magnetism and Magnetic Materials

      Volume: 323 Pages: 675-680

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] New Heat Generation Material in AC Magnetic Field for Y3Fe5O12-based Powder Material Synthesized by Reverse Coprecipitation2011

    • Author(s)
      H. Aono, T. Naohara, Y. Watanabe
    • Journal Title

      Method Materials Letters

      Volume: 65 Pages: 1454-1456

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of bead milling on heat generation ability in AC magnetic field of FeFe2O4 powder Materials2011

    • Author(s)
      T. Naohara, H. Aono, Y. Watanabe
    • Journal Title

      Chemistry and Physics

      Volume: 129 Pages: 1081-1088

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High heat generation ability in AC magnetic field for Y3Fe5O12 powder prepared using bead milling2011

    • Author(s)
      Aono, T. Naohara, Y. Watanabe
    • Journal Title

      Journal of the American Ceramic Society

      Volume: 94 Pages: 4116-4119

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat generation ability in AC magnetic field of needle-type Ti-coated mild steel for ablation cancer therapy2011

    • Author(s)
      Aono, T. Naohara, Y. Watanabe
    • Journal Title

      The International Journal for Computation and Mathematics in Electrical and Electronic Engineering

      Volume: 30 Pages: 1582-1588

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat generation ability in AC magnetic field and their computer Simulation for Ti tube filled with ferrite powder2011

    • Author(s)
      Takashi Naohara
    • Journal Title

      Journal of Magnetism and Magnetic Materials

      Volume: 323 Pages: 88-93

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of tailored, selective and effective anticancer chemotherapy by direct injection of decetaxel-loaded immunoliposomes into Her2 positive tumor xenografts2011

    • Author(s)
      Yuji Yamamoto
    • Journal Title

      International Journal of Oncology

      Volume: 38 Pages: 33-39

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat generation ability in AC magnetic field of nano MgFe2O4-based ferritfe powder prepared by bead milling2011

    • Author(s)
      Hiromichi Aono
    • Journal Title

      Journal of Magnetism and Magnetic Materials

      Volume: 323 Pages: 675-680

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of tailored, selective and effecive anticancer chemotherapy by direct injection of docetaxel-loaded immunoliposomes into Her2/neu positive gastric tumor xenografts2011

    • Author(s)
      Y.Yamamoto, Y.Watanbe, et al.
    • Journal Title

      International Journal of Oncology

      Volume: 38 Pages: 33-39

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat generation ability in AC magnetic field of nano MgFe2O4-based Ferrite powder prepared by bead milling2011

    • Author(s)
      H.Aono, Y.Watanabe, et al.
    • Journal Title

      Journal of Magnetism and Magnetic Materials

      Volume: 323 Pages: 675-680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat generation ability in AC magnetic field of needle-type Ti-coated mild steel for ablation cancer therapy2010

    • Author(s)
      T. Naohara, H. Aono, Y. Watanabe
    • Journal Title

      Proc. of International Symposium on Heating by Electromagnetic Sources

      Pages: 507-511

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat Generation Ability in AC Magnetic Field of Nano Sized Ferrite Powder Prepared by Physical Bead Milling for Thermal Coagulation Therapy2010

    • Author(s)
      T. Naohara, H. Aono, Y. Watanabe
    • Journal Title

      Proc. of International Symposium on Heating by Electromagnetic Sources

      Pages: 483-489

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High heat generation ability in AC magnetic field for Y3Fe5O12 powder prepared using bead milling2010

    • Author(s)
      H. Aono, T. Naohara, Y. Watanabe
    • Journal Title

      J. Ceram. Soc. Jpn

      Volume: 118 Pages: 384-386

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 子宮頸癌における誘導加熱治療法の検討2010

    • Author(s)
      猶原隆、渡部祐司
    • Journal Title

      生体医工学

      Volume: 47 Pages: 535-540

    • NAID

      10031199717

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of chemohyperthermia with decetaxel-embedded magnetoliposomes as minimally invasive local treatment for cancer2010

    • Author(s)
      M.Yoshida, Y.Watanabe, et al.
    • Journal Title

      International Journal of Cancer

      Volume: 126 Pages: 1955-1965

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of chemohyperthermia with docetaxel-embedded magnetoliposomes as minimally invasive local treatment for cancer2010

    • Author(s)
      M.Yoshida, Y.Watanabe, et al
    • Journal Title

      International Journal of Cancer 有(In press)

    • Related Report
      2009 Annual Research Report
  • [Presentation] 磁性体・抗癌剤同時包埋リポソームを用いた温熱化学療法と抗癌剤包埋免疫リポソームの有用性の検討2011

    • Author(s)
      渡部祐司
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学(東京都)(シンポジウム)(招待講演)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ナノテクノロジーと物理エネルギーを融合したハイブリッド標的化学診断・治療2011

    • Author(s)
      渡部祐司
    • Organizer
      第50回日本生体医工学会オーガナイズドセッション
    • Year and Date
      2011-04-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 磁性体・抗癌剤同時包埋リポソームを用いた温熱化学療法と抗癌剤包埋免疫リポソームの有用性の検討-ヒト胃癌マウス皮下腫瘍モデルに対する癌局所治療の検討-2011

    • Author(s)
      渡部祐司
    • Organizer
      第27回日本DDS学会シンポジウム
    • Related Report
      2011 Final Research Report
  • [Presentation] Her2陽性胃癌に対する免疫リポソームの抗腫瘍効果に対する検討2010

    • Author(s)
      山本祐司、渡部祐司, 他
    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      (国際会議場)名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌の交流磁場焼灼療法への応用を目的としたフェライト材料の設計2009

    • Author(s)
      H.Aono, Y.Watanabe
    • Organizer
      日本化学会2009
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Book] ハイパーサーミア癌温熱療法装置臨床工学講座医用治療機器学2011

    • Author(s)
      渡部祐司
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2011 Final Research Report
  • [Book] シミュレーション医学入門2011

    • Author(s)
      渡部祐司
    • Publisher
      株式会社篠原出版新社
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://kenqweb.office.ehime-u.ac.jp/Profiles/0008/0000537/profile.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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